Evaluation of anti-cataleptic effect of Levodopa-Carbidopa and sertraline in the parkinsonian rats

Subject Areas : Journal of Comparative Pathobiology

سیامک ریحانی راد ¹ , جواد محمودی ² , مجید خانمحمدی ³ , شلاله گنجی ⁴ , پیام سیفی ⁵

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Received: 2012-01-02 Accepted : 2012-05-09 Published : 2012-05-21

Keywords: Levodoap, Sertraline, Catalepsy, Rat,

Abstract :

Long-term administration of Levodopa in parkinsonian patients leads to development of somemotor disorders such as L-dopa induced dyskinesia and off-phenomena. Hence employment ofstrategy for effective treatment of this disease is of interest.In this investigation we attempted toevaluate the effect of sertraline on anti-cataleptic effect of L-dopa in 6-hydroxydopamine (6-OHDA) lesioned rats. Catalepsy was induced by infusion of 6-OHDA (8μg/2μl/rat) into theSubstantia nigra. These rats received intraperitoneally (i.p.) L-Dopa (15mg/kg) twice daily for20 consecutive days, and anti-cataleptic effect of L-dopa was evaluated by bar-test on days 5,10, 15 and 20. The results present that L-dopaexert anti-cataleptic effect only until day 15, andits effect was vanished on the day 20. On the day 21, these rats co-injected with three differentdoses of sertraline (0.5, 1and 2mg/kg, i.p.) and L-dopa (15mg/kg, ip). Sertralineat the dose of 2mg/kg improved the anti-cataleptic effect of L-dopa. Furthermore, the effect of sertraline (2mg/kg, i.p.) on anti-cataleptic effect of L-dopa (15mg/kg, ip) was antagonised by NAN-190 (0.5mg/kg, i.p.) as a 5-HT1A receptor antagonist. Theseresults showed that sertraline improvestheanti-cataleptic effect of L-dopa in the 6-OHDA-lesioned rats and probably this effect mediatedthrough activation of 5HT1A receptors.