Anti-nociceptive effects of Froriepia subpinnata following Acid acetic induced inflammatory pain in mice

Subject Areas :

O Asarian ¹ , s hassanpour ^{2 *} , H Erikaghaji ³

1 - Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
2 - Department of Veterinary Physiology, Science and Research Branch, Islamic Azad University, Tehran, Iran
3 - Science and Research Branch, Islamic Azad University, Tehran, Iran

Received: 2025-03-22 Accepted : 2025-07-04 Published : 2025-06-19

Keywords: Froriepia subpinnata, Analgesic, Mice,

Abstract :

Neuropathic pain is a chronic condition that is carried out by complex mechanisms through nerve mediators. Therefore, the aim of the present study was to determine Anti-nociceptive effects of Froriepia subpinnata extract following Acid acetic induced inflammatory pain in mice. In this study, 85 adult male mice were divided into 4 experiments with 4 groups. In experiment 1, peritoneal animals received saline, Froriepia subpinnata (100, 200, and 400 mg/kg) extract and morphine (5 mg/kg). In experiment 2, animals received saline, Froriepia subpinnata extract (400 mg/kg), naloxone (2 mg/kg), and naloxone + Froriepia subpinnata co-injection. Experiments 3 and 4 were identical to Experiment 2, except that rats were injected with L-NAME (10 mg/kg) and cyproheptadine (4 mg/kg) instead of naloxone. Writhing test was done by, injection of the acetic acid and the percentage of inhibition of abdominal contractions was recorded. Based on the findings, Froriepia subpinnata significantly inhibited the abdominal contractions caused by the injection of acetic acid (P<0.05). The co-injection of naloxone plus Froriepia subpinnata significantly reduced the analgesic effects of Froriepia subpinnata compared to the troxerutin group (P<0.05). The combined injection of L-NAME + Froriepia subpinnata significantly inhibited abdominal contractions caused by acetic acid injection (P<0.05). The combined injection of L-NAME + Froriepia subpinnata significantly inhibited abdominal contractions caused by acetic acid injection (P<0.05).

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