Comparative study of the anti-anxiety effects of extracts from Tilia platyphyllos scop., Viscum album, Lavandula stoechas, and diazepam in rats
Subject Areas :
Mehrdad Pashazadeh
1
,
abolfazl jafari sales
2
,
faezeh mehdizadeh
3
,
Kosar Soleymanpour
4
,
Kosar Hosseini-Karkaj
5
,
A. Rezaie
6
*
1 - Department of Immunology, Faculty of Medicine, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran
2 - Department of Microbiology School of Basic Sciences, Kazerun Branch, Islamic Azad University, Kazerun, Iran
3 - Department of Microbiology, Faculty of Basic Sciences, Islamic Azad University, Tabriz, Iran.
4 - Department of Cellular and Molecular Biology, Faculty of Basic Sciences, Tabriz Branch, Islamic Azad University, Tabriz, Iran
5 - Department of Cellular and Molecular Biology, Faculty of Basic Sciences, Tabriz Branch, Islamic Azad University, Tabriz, Iran
6 - Azaduniversity tabriz, Iran
Keywords: Tilia platyphyllos scop., Viscum album, Lavandula stoechas, Antianxiety, Rat,
Abstract :
Medicinal plants such as Tilia platyphyllos (T. platyphyllos), Viscum album (V. album), and Lavandula stoechas (L. stoechas) have been utilized in traditional medicine in Iran and other countries due to their various pharmacological effects. Therefore, the aim of this study was to comparatively investigate the anxiolytic effects of the extracts of T. platyphyllos, V. album, and L. stoechas and diazepam in rats. In this experimental intervention study, 125 Wistar rats were used in different groups, and thirty minutes prior to each test, three doses of T. platyphyllos extract (150, 300, and 450 mg/kg), three doses of V. album extract (150, 300, and 450 mg/kg), three doses of L. stoechas extract (100, 200, and 400 mg/kg), and dimethyl sulfoxide (DMSO) as a placebo were administered intraperitoneally along with diazepam at a dose of 1.2 mg/kg. The anxiolytic effects were assessed using the Elevated Plus Maze test. The results indicated a significant increase in the duration of sleep induced by ketamine, as well as a significant increase in the treatment groups with the aforementioned doses of extracts (p < 0.01). Considering the anxiolytic effects of these plants, the results showed that the extract of V. album at a dose of 450 mg/kg had better effects compared to T. platyphyllos at a dose of 300 mg/kg and L. stoechas at a dose of 200 mg/kg.
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