The interaction of thiamine and zinc oxide nanoparticles on the renal parenchyma structure alterations

Subject Areas : Journal of Comparative Pathobiology

Rahmat alla Fatahian ¹ , Behnaz Karimi ² , Jahangir Kaboutari ³ , Reza Hoseini ⁴ , kianoush Frouhar ⁵

1 - دانشیار گروه علوم پایه دانشکده دامپزشکی و پژوهشکده بیماری های مشترک انسان و دام دانشگاه شهرکرد . شهرکرد، ایران
2 - Department of Biochemistry, Department of Basic Sciences, Shahrekord Faculty of Veterinary Medicine, Shahrekord, Iran
3 - Department of Basic Sciences, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran.
4 - PhD student in veterinary medicine, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord-Iran
5 - PhD student in veterinary medicine, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord-Iran

Received: 2024-03-06 Accepted : 2024-05-03 Published : 2024-06-20

Keywords: Mouse, Thiamine, Zinc oxide nanoparticles, Histology of biochemical reactions,

Abstract :

Along with the rapid development of nanomaterials technologies, zinc oxide nanoparticles are widely used in various aspects of human life. In this study, the histological changes of the kidney structure in the presence of thiamin were evaluated against the administration of zinc oxide nanoparticles in mice. 20 adult male Wistar rats were selected and randomly divided into 4 groups of 8. The first group, the control group; the second group, thiamine group (30 mg/kg of body weight); The third group, the group of zinc oxide nanoparticles (50 mg/kg of body weight) and the fourth group, the group of zinc oxide nanoparticles together with thiamine were considered. All injections were done intraperitoneally and all the conditions of animal rights were observed. At the end of the experiment, animal blood was taken to use the serum for biochemical tests and kidney tissue samples were taken to continue the slide preparation process. The results showed that obvious histological changes could be seen in the group of nanoparticles. Blood glucose and HDL showed a significant decrease in the nanoparticles group compared to the control group. On the other hand, cholesterol, LDL, BUN and creatinine showed a significant increase in the nanoparticles group compared to the control group. The simultaneous injection of nanoparticles with thiamine had reduced the tissue and biochemical changes largely. Thiamine can control the harmful effects of high dose of zinc oxide nanoparticles on all rats.

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