Protective effect of nanocurcumin on renal histological damage in salinomycin-induced toxicity of broiler chickens

Subject Areas : Pathology

Seyed Mohammad  Hosseini ¹ (Department of Pathology, Faculty of Veterinary Medicine, Babol Branch, Islamic Azad University, Babol, Iran)
Reza  Sayrafi ² (Department of Veterinary Basic Sciences, Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran)
Saber  Yousefi-Robati ³ (Department of Pathology, Faculty of Veterinary Medicine, Babol Branch, Islamic Azad University, Babol, Iran )
Abolfazl  Akbari ⁴ (Department of Physiology, School of Veterinary Medicine, Shiraz University, Shiraz, IranDepartment of Exercise Physiology, Faculty of Sport Science, University of Mazandaran, Babolsar, Iran)
Alireza  Salehi ⁵ (Department of Pathology, Faculty of Veterinary Medicine, Babol Branch, Islamic Azad University, Babol, Iran)

Received: 2023-08-15 Accepted : 2024-01-16 Published : 2024-03-03

Keywords: Nanocurcumin, Salinomycin, Kidney, Antioxidant, Broiler chickens,

Abstract :

Salinomycin (SLM) is an ionophore antibiotic used extensively in the poultry industry for the control and prevention of coccidiosis. The toxicity of the ionophore is thought to be due to oxidative damage caused by the production of free radicals. Curcumin is a major component of turmeric, which has a wide range of antioxidant, anti-inflammatory and anticancer activities. The aim of this study was to evaluate the effect of nanocurcumin (NC) as a natural antioxidant on broiler chickens poisoned with a toxic dose of SLM. In this study, 60 broilers were randomly divided into 5 groups. The first group was considered as control. The second group received SLM at a dose of 300 mg/kg bw per day for 14 days. Groups 3, 4 and 5 received oral doses of NC at 50, 100 and 200 mg/kg bw per day for 14 days in addition to SLM. After 14 days, blood and kidney tissue samples were collected for biochemical and histopathological evaluation. It was observed that NC reduced the incidence and severity of renal histopathological lesions. The highest levels of inflammatory cells were observed in the cortex and medulla of the SLM group and it appeared that treatment with NC improved the condition and reduced the presence of inflammatory cells. It also significantly improved renal histomorphometric parameters (P<0.05). It seemed that SLM-induced adverse conditions can be reversed by oral administration of NC.

References:

[1] Fayer R. Epidemiology of protozoan infections: the coccidia. Veterinary Parasitology. 1980; 6(1-3): 75-103. doi:10.1016/0304-4017(80)90039-4
[2] McDougald LR, Cervantes HM, Jenkins MC, Hess M, Beckstead R. Protozoal infections. Diseases of poultry. 2020: 1192-254. doi:10.1002/9781119421481.ch28
[3] Blake DP, Knox J, Dehaeck B, Huntington B, Rathinam T, Ravipati V. et al. Re-calculating the cost of coccidiosis in chickens. Veterinary Research. 2020; 51: 1-14. doi:10.1186/s13567-020-00837-2
[4] Meluzzi A, Sirri F. Welfare of broiler chickens. Italian Journal of Animal Science. 2009; 8(sup1): 161-73. doi:10.4081/ijas.2009.s1.161
[5] Quiroz-Castañeda RE, Dantán-González E. Control of avian coccidiosis: future and present natural alternatives. BioMed research international. 2015; 2015. doi:10.1155/2015/430610
[6] Noack S, Chapman HD, Selzer PM. Anticoccidial drugs of the livestock industry. Parasitology research. 2019;118: 2009-26.
doi:10.1007/s00436-019-06343-5
[7] Additives EPo, Feed PoSuiA, Rychen G, Aquilina G, Azimonti G, Bampidis V, et al. Safety and efficacy of Sacox® microGranulate (salinomycin sodium) for rabbits for fattening. EFSA Journal. 2018; 16(3): e05209. doi:10.2903/j.efsa.2018.5209
[8] Kamashi K, Reddy AG, Reddy K, Reddy V. Evaluation of zinc against salinomycin toxicity in broilers. Indian journal of physiology and pharmacology. 2004; 48(1): 89-95.
[9] Sayrafi R, Hosseini S, Ahmadi M. The protective effects of nanocurcumin on liver toxicity induced by salinomycin in broiler chickens. Revue de Medicine Veterainare. 2017; 168: 136-42.
[10] Khan M, Szarek J, Marchaluk E, Macig A, Bartlewski P. Effects of concurrent administration of monensin and selenium on erythrocyte glutathione peroxidase activity and liver selenium concentration in broiler chickens. Biological trace element research. 1995; 49: 129-38. doi:10.1007/BF02788962
[11] Deb N, Majumdar P, Ghosh AK. Pharmacognostic and phytochemical evaluation of the rhizomes of Curcuma longa Linn. Journal of PharmaSciTech. 2013; 2(2): 81-6.
[12] Farooqui T, Farooqui AA. Curcumin: Historical background, chemistry, pharmacological action, and potential therapeutic value. Curcumin for Neurological and Psychiatric Disorders. 2019: 23-44. doi:10.1016/B978-0-12-815461-8.00002-5
[13] Alsamydai A, Jaber N. Pharmacological aspects of curcumin. International Journal of Pharmaceutics. 2018; 5(6): 313-26.
doi:10.13040/IJPSR.0975-8232.IJP.5(6).313-326
[14] Epstein J, Sanderson IR, MacDonald TT. Curcumin as a therapeutic agent: the evidence from in vitro, animal and human studies. British journal of nutrition. 2010; 103(11): 1545-57.
doi:10.1017/S0007114509993667
[15] Kuttan R, Sudheeran P, Josph C. Turmeric and curcumin as topical agents in cancer therapy. Tumori Journal. 1987; 73(1): 29-31. doi:10.1177/030089168707300105
[16] Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: problems and promises. Molecular pharmaceutics. 2007; 4(6): 807-18.
doi:10.1021/mp700113r
[17] Yallapu MM, Nagesh PKB, Jaggi M, Chauhan SC. Therapeutic applications of curcumin nanoformulations. The AAPS journal. 2015; 17: 1341-56.
doi:10.1208/s12248-015-9811-z
[18] Kotha RR, Luthria DL. Curcumin: biological, pharmaceutical, nutraceutical, and analytical aspects. Molecules. 2019; 24(16):2 930. doi:10.3390/molecules24162930
[19] Naksuriya O, Okonogi S, Schiffelers RM, Hennink WE. Curcumin nanoformulations: a review of pharmaceutical properties and preclinical studies and clinical data related to cancer treatment. Biomaterials. 2014; 35(10): 3365-83.
doi:10.1016/j.biomaterials.2013.12.090
[20] Yadav A, Lomash V, Samim M, Flora SJ. Curcumin encapsulated in chitosan nanoparticles: a novel strategy for the treatment of arsenic toxicity. Chemico-Biological Interactions. 2012; 199(1): 49-61. doi:10.1016/j.cbi.2012.05.011
[21] Rahimi HR, Nedaeinia R, Shamloo AS, Nikdoust S, Oskuee RK. Novel delivery system for natural products: Nano-curcumin formulations. Avicenna journal of phytomedicine. 2016; 6(4): 383-98.
[22] Del Prado-Audelo ML, Caballero-Florán IH, Meza-Toledo JA, Mendoza-Muñoz N, González-Torres M, Florán B, et al. Formulations of curcumin nanoparticles for brain diseases. Biomolecules. 2019; 9(2): 56. doi:10.3390/biom9020056
[23] Yavarpour-Bali H, Ghasemi-Kasman M, Pirzadeh M. Curcumin-loaded nanoparticles: A novel therapeutic strategy in treatment of central nervous system disorders. International journal of nanomedicine. 2019: 4449-60. doi:10.2147/IJN.S208332
[24] Yen F-L, Wu T-H, Tzeng C-W, Lin L-T, Lin C-C. Curcumin nanoparticles improve the physicochemical properties of curcumin and effectively enhance its antioxidant and antihepatoma activities. Journal of agricultural and food chemistry. 2010; 58(12): 7376-82. doi:10.1021/jf100135h
[25] Peyron C, Lecoindre P, Chevallier M, Guerret S, Pagnon A. Vacuolar hepatopathy in 43 French Scottish Terriers: a morphological study. Revue de médecine vétérinaire. 2015; 166(7-8): 176-84.
[26] Sultana N, Islam R, Akter A, Ayman U, Bhakta S, Rony SA, et al. Biochemical and morphological attributes of broiler kidney in response to dietary glucocorticoid, dexamethasone. Saudi journal of biological sciences. 2021; 28(12): 6721-9.
doi:10.1016/j.sjbs.2021.07.047
[27] Hosseini SM, Hejazian LB, Amani R, Siahchehreh Badeli N. Geraniol attenuates oxidative stress, bioaccumulation, serological and histopathological changes during aluminum chloride-hepatopancreatic toxicity in male Wistar rats. Environmental Science and Pollution Research. 2020; 27(16): 20076-89. doi:10.1007/s11356-020-08128-1
[28] Blazka ME, Elwell MR, Holladay SD, Wilson RE, Luster MI. Histopathology of acetaminophen-induced liver changes: role of interleukin 1α and tumor necrosis factor α. Toxicologic pathology. 1996; 24(2): 181-9. doi:10.1177/019262339602400206
[29] Rippere-Lampe KE, Lang M, Ceri H, Olson M, Lockman HA, O'Brien A. Cytotoxic necrotizing factor type 1-positive Escherichia coli causes increased inflammation and tissue damage to the prostate in a rat prostatitis model. Infection and immunity. 2001; 69(10): 6515-9.
doi:10.1128/IAI.69.10.6515-6519.2001
[30] Williams JA, Barreiro CJ, Nwakanma LU, Lange MS, Kratz LE, Blue ME, et al. Valproic acid prevents brain injury in a canine model of hypothermic circulatory arrest: a promising new approach to neuroprotection during cardiac surgery. The Annals of thoracic surgery. 2006; 81(6): 2235-42.
doi:10.1016/j.athoracsur.2005.12.060
[31] Gibson-Corley KN, Olivier AK, Meyerholz DK. Principles for valid histopathologic scoring in research. Veterinary pathology. 2013; 50(6): 1007-15.
doi:10.1177/0300985813485099
[32] Rahimi O, Asadi Louie N, Salehi A, Faed Maleki F. Hepatorenal protective effects of hydroalcoholic extract of Solidago canadensis L. against Paracetamol-induced toxicity in mice. Journal of Toxicology. 2022; 2022. doi:10.1155/2022/9091605
[33] Salehi A, Hosseini SM, Kazemi S. Antioxidant and anticarcinogenic potentials of propolis for dimethylhydrazine-induced colorectal cancer in Wistar rats. BioMed Research International. 2022; 2022. doi:10.1155/2022/8497562
[34] Valaei A, Azadeh F, Mostafavi Niaki ST, Salehi A, Shakib Khoob M, Kazemi S, et al. Antioxidant and anticancer potentials of the Olive and Sesame mixture against dimethylhydrazine-induced colorectal cancer in Wistar rats. BioMed Research International. 2022; 2022. doi:10.1155/2022/5440773
[35] Sayrafi R, Mirzakhani N, Mobaseri R. Effects of turmeric (Curcuma longa) and vitamin E on histopathological lesions induced in bursa of Fabricius of broiler chicks by salinomycin. Veterinary Research Forum; 2017: 8(3): 231-6.
[36] Peixoto PV, Nogueira VA, Gonzaléz AP, Tokarnia CH, França TN. Accidental and experimental salinomycin poisoning in rabbits. Pesquisa Veterinária Brasileira. 2009; 29: 695-9.
doi:10.1590/S0100-736X2009000900002
[37] Bordeanu A-D, Kiss T, Krupaci F-A, Sandru CD, Spinu M. A comparative evaluation of carried bacterial strains in sheep and goats raised in a mixed heard. Lucrari Stiintifice Medicina Veterinara. 2013; 46(2): 5-9.
[38] Bila C, Perreira C, Gruys E. Accidental monensin toxicosis in horses in Mozambique. Journal of the South African Veterinary Association. 2001; 72(3): 163-4.
doi:10.4102/jsava.v72i3.641
[39] Marsh DC, Vreugdenhil PK, Mack VE, Belzer FO, Southard JH. Glycine protects hepatocytes from injury caused by anoxia, cold ischemia and mitochondrial inhibitors, but not injury caused by calcium ionophores or oxidative stress. Hepatology. 1993; 17(1): 91-8.
[40] Madhavi K, Saraswathi VS. In vivo toxicological evaluation of chlorpyrifos pesticide on female albino mice: Therapeutic effects of Curcuma longa. International Journal of Pharmaceutical Sciences and Research. 2011; 2: 439-47.
[41] Yang S, Chou W-P, Pei L. Effects of propofol on renal ischemia/reperfusion injury in rats. Experimental and therapeutic medicine. 2013; 6(5): 1177-83.
doi:10.3892/etm.2013.1305
[42] Hosseini A, Hosseinzadeh H. Antidotal or protective effects of Curcuma longa (turmeric) and its active ingredient, curcumin, against natural and chemical toxicities: A review. Biomedicine & pharmacotherapy. 2018; 99: 411-21.
doi:10.1016/j.biopha.2018.01.072
[43] Verma RK, Kumari P, Maurya RK, Kumar V, Verma R, Singh RK. Medicinal properties of turmeric (Curcuma longa L.): A review. International Journal of Chemical Studies. 2018; 6(4): 1354-7.
[44] Farkhondeh T, Samarghandian S. The hepatoprotective effects of curcumin against drugs and toxic agents: an updated review. Toxin reviews. 2016; 35(3-4): 133-40. doi:10.1080/15569543.2016.1215333
[45] Gowda NK, Ledoux DR, Rottinghaus GE, Bermudez AJ, Chen YC. Antioxidant efficacy of curcuminoids from turmeric (Curcuma longa L.) powder in broiler chickens fed diets containing aflatoxin B1. British Journal of Nutrition. 2009; 102(11): 1629-34.
doi:10.1017/S0007114509990869
[46] Shin HJ, Lee JY, Son E, Lee DH, Kim HJ, Kang SS, et al. Curcumin attenuates the kainic acid-induced hippocampal cell death in the mice. Neuroscience letters. 2007; 416(1): 49-54. doi:10.1016/j.neulet.2007.01.060
[47] Maheshwari RK, Singh AK, Gaddipati J, Srimal RC. Multiple biological activities of curcumin: a short review. Life sciences. 2006; 78(18): 2081-7.
doi:10.1016/j.lfs.2005.12.007
[48] Woo J-H, Kim Y-H, Choi Y-J, Kim D-G, Lee K-S, Bae JH, et al. Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-X L and IAP, the release of cytochrome c and inhibition of Akt. Carcinogenesis. 2003; 24(7): 1199-208. doi;10.1093/carcin/bgg082
[49] Joe B, Vijaykumar M, Lokesh B. Biological properties of curcumin-cellular and molecular mechanisms of action. Critical reviews in food science and nutrition. 2004; 44(2): 97-111.
doi:10.1080/10408690490424702
[50] Arshami J, Pilevar M, Azghadi MA, Raji AR. Hypolipidemic and antioxidative effects of curcumin on blood parameters, humoral immunity, and jejunum histology in Hy-line hens. Avicenna journal of phytomedicine. 2013; 3(2): 178.
[51] Wu N, Li W, Shu W, Jia D. Protective effect of picroside II on myocardial ischemia reperfusion injury in rats. Drug Design, Development and Therapy. 2014: 545-54.
doi:10.2147/DDDT.S62355
[52] Rahmi DNI, Louisa M, Soetikno V. Effects of curcumin and nanocurcumin on cisplatin-induced nephrotoxicity in rat: Copper transporter 1 and organic cation transporter 2 as drug transporters. 2018; 10(1): 172. doi:10.22159/ijap.2018.v10s1.37
[53] Leshchinsky T, Klasing K. Relationship between the level of dietary vitamin E and the immune response of broiler chickens. Poultry Science. 2001; 80(11): 1590-9. doi:10.1093/ps/80.11.1590
[54] Alvarino A, Yanwirasti Y, editors. Nano curcumin effect for kidney fibrotic caused by unilateral ureter obstruction based on expression matrix metalloproteinase-9. Proceedings of the 1st EAI International Conference on Medical And Health Research, ICoMHER November 13-14th 2018, Padang, West Sumatera, Indonesia; 2019.
doi:10.4108/eai.13-11-2018.2283528
[55] Khadrawy YA, Hosny EN, El-Gizawy MM, Sawie HG, Aboul Ezz HS. The effect of curcumin nanoparticles on cisplatin-induced cardiotoxicity in male Wistar albino rats. Cardiovascular Toxicology. 2021; 21: 433-43.
doi:10.1007/s12012-021-09636-3
[56] Tipu MA, Pasha T, Ali Z. Comparative efficacy of salinomycin sodium and neem fruit (Azadirachta indica) as feed additive anticoccidials in broilers. International Journal of Poultry Science. 2002; 1(4): 91-3. doi:10.3923/ijps.2002.91.93
[57] Chapman H, Skinner J, Waldroup P, Schleifer J. Research note: Does compensatory growth occur following withdrawal of salinomycin from the diet of broilers? Poultry science. 1993; 72(2): 383-6. doi:10.3382/ps.0720383
[58] Ruff M, Reid W, Johnson J, Anderson W. Anticoccidial activity of narasin in battery raised broiler chickens. Poultry Science. 1979; 58(2): 298-303.
doi:10.3382/ps.0580298