اثر محافظتی نانوکورکومین بر آسیب بافتی کلیوی در مسمومیت ناشی از سالینومایسین جوجه های گوشتی
Subject Areas : PathologySeyed Mohammad Hosseini 1 * , Reza Sayrafi 2 , Saber Yousefi-Robati 3 , Abolfazl Akbari 4 , Alireza Salehi 5
1 - بخش پاتولوژی، دانشکده دامپزشکی، واحد بابل ، دانشگاه آزاد اسلامی، بابل ، ایران
2 - بخش علوم پایه، دانشکده دامپزشکی، دانشگاه تخصصی فناوری های نوین آمل، آمل ، ایران
3 - بخش پاتولوژی، دانشکده دامپزشکی، واحد بابل ، دانشگاه آزاد اسلامی، بابل ، ایران
4 - بخش فیزیولوژی ، دانشکده دامپزشکی، دانشگاه شیراز، شیراز، ایران ; بخش فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه مازندران، بابلسر، ایران
5 - بخش پاتولوژی، دانشکده دامپزشکی، واحد بابل ، دانشگاه آزاد اسلامی، بابل ، ایران
Keywords: نانوکورکومین, سالینومایسین, کلیه, آنتی اکسیدان, جوجه گوشتی,
Abstract :
سالینومایسین یک آنتی بیوتیک یونوفوره بوده که به طور گسترده در صنعت طیور برای کنترل و پیشگیری از کوکسیدیوز استفاده می شود. سمیت یونوفور احتمالاً به دلیل آسیب اکسیداتیو ناشی از تولید رادیکال های آزاد است. کورکومین جزء اصلی زردچوبه بوده که دارای طیف وسیعی از فعالیت آنتی اکسیدانی، ضد التهابی و ضد سرطانی است. هدف از این مطالعه بررسی اثر نانو کورکومین به عنوان یک آنتی اکسیدان طبیعی بر جوجه های گوشتی مسموم شده با دوز سمی سالینومایسین بود. در این مطالعه 60 قطعه جوجه گوشتی به طور تصادفی به 5 گروه تقسیم شدند. گروه اول به عنوان شاهد در نظر گرفته شد. گروه دوم سالینومایسین را با دوز 300 میلی گرم بر کیلوگرم وزن بدن، روزانه به مدت 14 روز دریافت کردند. گروه های 3، 4 و 5 علاوه بر سالینومایسین، به ترتیب روزانه 50، 100 و 200 میلی گرم بر کیلوگرم وزن بدن نانوکورکومین را به مدت 14 روز دریافت کردند. سپس، نمونه های خون و بافت برای ارزیابی بیوشیمیایی و هیستوپاتولوژی جمع آوری شد. مشاهده شد که نانوکورکومین بروز و شدت ضایعات هیستوپاتولوژیک کلیه را کاهش داده و به نظر می رسد که درمان با نانوکورکومین باعث بهبود وضعیت و کاهش تعداد سلول های التهابی می شود. همچنین پارامترهای هیستومورفومتری را به طور معنی داری بهبود بخشید (05/0>p). به نظر می رسد شرایط نامطلوب ناشی از مسمومیت با سالینومایسین با تجویز خوراکی نانوکورکومین قابل بهبود باشد.
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