Comparison of Anesthesia Induced by Isoflurane, Ketamine, and Ketamine-Diazepam in Male Rats
Shahram Saghaei
1
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گروه پاتوبیولوژی، دانشکده دامپزشکی، واحد ارومیه، دانشگاه آزاد اسلامی، ارومیه، ایران
)
Keywords: Isoflurane, Rat, Propofol, Injectable anesthetic, Diazepam,
Abstract :
Isoflurane is an inhalational anesthetic. Moreover, the combination of ketamine and diazepam is commonly used as an anesthetic agent. The present study aimed to investigate the anesthesia induced by isoflurane, ketamine, and ketamine-diazepam on anesthesia-related factors in rats.
Thirty male rats were divided into three groups of ten each. Each group was anesthetized using one of the following anesthetics: isoflurane gas, ketamine, and the combination of ketamine and diazepam. The variables of heart rate, respiratory rate, body temperature, pain reflexes (ear, tail, and pedal reflexes), duration of anesthesia induction, surgical anesthesia, and movement time were recorded.
According to our results, the duration of surgical anesthesia was significantly lower in the ketamine-diazepam group compared to the other groups. Moreover, the duration of anesthesia induction was shorter in the ketamine-diazepam group compared to the other groups. However, heart rate, respiratory rate, and body temperature were significantly lower in the isoflurane-only group compared to the other groups. Also, pain reflex scores were significantly higher in the isoflurane-only group compared to the ketamine-only group. However, the ketamine-only and ketamine-diazepam groups were similar in pain reflex scores.
It is recommended to perform further studies comparing injectable anesthesia agents, such as propofol, with inhalational anesthesia agents.