Abstract :
In this study, TiO2-MgO mesoporous particles were prepared via evaporation-induced self assembly method using two different copolymers of polyvinylpyridine-polystyrene )PVP-PS( and polyethylene glycol-polypropylene glycol-polyethylene glycol )PEG-PPG-PEO or PEO-PPO-PEO) as structure directing agents. The characteristics of the products were investigated by X-ray diffraction )XRD(, nitrogen adsorption-desorption isotherm )BET-BJH(, Fourier transform infrared spectrometry )FT-IR(, and scanning electron microscopy )SEM(. The effects of polymer type, different amounts of magnesium, and calcination temperature were studied. The results showed that the use of (PEO-PPO-PEO) copolymer and increasing the amount of magnesium nitrate increased the surface area of the products. In addition, increasing of calcination temperature from 400 to 550 oC leads to a reduction in surface area of the samples. Simvastatin was loaded on the prepared samples and drug release was studied in simulated gastrointestinal fluid. The release profile of simvastatin fluid from the TiO2-MgO sample, prepared by using )PEO-PPO-PEO(, in the simulated gastric and intestinal within 20 hours showed 100 and 70%, respectively.
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