Electrochemical sensor for fentanyl determination by modified electrode with carbon nanotube and iron (III) oxide nanoparticles

Subject Areas :

مصطفی نجفی ¹ , اسماعیل سهولی ²

1 - دانشیار شیمی تجزیه، گروه شیمی، دانشکده و پژوهشکده علوم پایه، دانشگاه جامع امام حسین (ع)، تهران، ایران
2 - دانشجوی دکتری شیمی تجزیه، گروه شیمی، دانشکده و پژوهشکده علوم پایه، دانشگاه جامع امام حسین (ع)، تهران، ایران

Received: 2017-05-08 Accepted : 2018-01-08 Published : 2018-05-22

Keywords: fentanyl, Multi-walled carbon nanotubes, Electrochemical sensor, Fe2O3 nanoparticles,

Abstract :

Fentanyl is a rapid-acting, analgesic drug, and a powerful opioid which is extensively used for anesthesia and chronic pain management. In this study, an electrochemical sensor based on a nanocomposite of multi wall carbon nanotubes )MWCNTs( and iron )III( oxide )Fe2O3( nanoparticles on the surface of glassy carbon electrode )GCE( was investigated for the analysis of fentanyl drug in aqueous media. The surface of modified electrode was studied with scanning electron microscope (SEM). The electrochemical behavior of modified electrode and determination of fentanyl were performed by cyclic voltammetry and differential pulse voltammetry )DPV(, respectively. The differential pulse voltammetry (DPV) measurement at the surface of modified electrode presented the linear relation between the anodic peak current and fentanyl concentration in tow range of 0.08 to 1 and 1 to 100 μM with limits of detection (LOD) of 0.045 μM. The effect of some potential interferences of electrode response was investigated. The proposed sensor was successfully employed for the determination of fentanyl in human blood serum and urine samples

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