Application of Nano Hydrogels In Improving The Performance Of Wound Dressings and Drug Delivery: A Review Study

Subject Areas :

MohammadHossein Karami ¹ , Majid Abdouss ² , MohammadReza Kalaee ³ , Omid Moradi ⁴

1 - Department of Chemistry, Amirkabir University of Technology, Tehran P.O. Box 15875-4413, Tehran, Iran
2 - Department of Chemistry, Amirkabir University of Technology, Tehran P.O. Box 15875-4413, Tehran, Iran
3 - Department of Polymer Engineering, Faculty of Engineering, South Tehran Branch, Islamic Azad University, P.O. Box: 19585-466, Tehran, Iran.
4 - Department of Chemistry, Shahre-Qods Branch, Islamic Azad University, Shahre-Qods 37515-374, Tehran, Iran

Received: 2023-04-04 Accepted : 2023-05-01 Published : 2023-08-23

Keywords: Wound Dressing, Antibacterial, Drug release, metal nanoparticles, Nano Hydrogel,

Abstract :

One of the most common clinical diseases is skin scarring, which is defined as damage to the structure or integrity of skin tissue. Nanohydrogel can help in sustained release of drug by entrapping drug or loading drugs and thus promote wound healing. A hydrogel is a three-dimensional hydrophilic network that is insoluble in water or aqueous solutions and is able to absorb water or other biological fluids that can promote wound healing. Various nano hydrogels have been designed to improve the design of wound dressings, and nano hydrogels are also used in drug release. The advantage of hydrogels over traditional wound dressings is their ability to improve the wound and the wound healing process. Hydrogels meet most criteria for modern wound dressings due to their unique properties. Among the unique properties of nano-hydrogels, we can mention the ability to absorb wound secretions, maintain a moist environment, gas exchange, remove the dressing from the wound surface without pain and replace the dressing for the patient, ease of movement for surgery. In this research, an overview of the use of nano-hydrogels in improving the performance of wound dressings and drug delivery, along with the investigation of antibacterial properties, introduction of commercial wound dressings and wound healing mechanisms, has been discussed.