PEGylation of polyamidoamine-G3 dendrimer bonded with silica-coated magnetic nanoparticles as a pH-sensitive targeted drug delivery system

Subject Areas :

seyed esmaeil mhamadi mehr ¹ , Mehdi Faramarzi ² , seyed abotaleb mosavi parsa ³

1 - دانشجوی دکتری گروه مهندسی شیمی، واحد یاسوج، دانشگاه آزاد اسلامی، یاسوج، ایران
2 - Department of Chemical Engineering,, Gachsaran Branch, Islamic Azad University, Gachsaran, Iran
3 - استادیار گروه مهندسی شیمی، واحد یاسوج، دنشگاه آزاد اسلامی، یاسوج، ایران

Received: 2020-05-21 Accepted : 2021-01-03 Published : 2021-08-23

Keywords: cancer, Iron oxide nanoparticles, targeted drug delivery, PEGylation, Controlled drug release,

Abstract :

This research, reports the fabrication of a new pH-responsive nanocarrier based on iron oxide nanoparticle with dendrimer coating and PEG conjugated for targeted and controlled delivery of chemotherapy drugs to cancer cells. The structure of the nanocarrier was confirmed by Fourier transform infrared (FT-IR) spectra analysis. transmission electron microscope (TEM), Field Emission Scanning Electron Microscopy (FE-SEM) and vibrating sample magnetometer (VSM) analysis showed that the nanocarrier has a spherical structure with super paramagnetic properties. The efficiency of nanocarrier was evaluated with cyclophosphamide chemotherapy drug. The in vitro drug release studies at different pH proved the pH-sensitivity of the nanocarrier. Due to the open state of dendritic structure in acidic pH, the maximum release observed at pH 4.5 (lysosomal pH). Mass transfer studies showed that drug release from nanocarrier is rapid in short contact time and slow in long contact time. These results indicate that cyclophosphamide-loaded magnetic nanocarrier is promising for targeted delivery and controlled drug release.

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