Catalyst-free synthesis of aminothiazole derivatives in water

Ghasemian Dazmiri, Mahboubeh; Ghasemi, Narges; Noushin, Annataj

Manuscript ID : 697969 Visit : 56 Page: 3421 - 3424

Article Type: Original Research

Catalyst-free synthesis of aminothiazole derivatives in water

Subject Areas : Iranian Journal of Organic Chemistry

Mahboubeh Ghasemian Dazmiri ¹ ()
Narges Ghasemi ² ()
Annataj Noushin ³ ()

Received: 2022-12-21 Accepted : 2022-12-21 Published : 2022-08-01

Keywords: Primary Amines, aminothiazole, Phosphonate, Phosphites, Activated acetylenic compound, Benzoylisothiocyanates,

Abstract :

Functionalized aminothiazole are generated from the reaction of dimethyl acetylenedicarboxylate, benzoylisothiocyanates, primary amines, hydrazonoyl chloride and triphenylphosphine in water. Particularly valuable features of this method include high yields of products, broad substrate scope, short reaction time and straightforward procedure.

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Mechanistic Investigation of the [1+4] Cycloaddition Reaction Between Alkyl Isocyanides and 3-benzylidene-2,4-pentanedione: A Theoretical Study
Print Date : 2020-07-17
Synthesis and characterization of PTS and PDATS: Two maiden functionalized energetic polymers having tetrazole and triazine rings
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BF3 catalyzed hydroarylation reactions of arylsubstituted alkynes with different electron rich arenes
Print Date : 2014-11-01
Synthesis of some 3-indolyl heterocycles and evaluation of its antimicrobial activity
Print Date : 2016-08-01
1,3,4-Thiadiazole rings as π-spacers in triphenylamine based dyes: A density functional theory study of reactivity, UV/Visible spectra, structural and optical properties
Print Date : 2015-11-01
Graphical Abstract
Print Date : 2014-05-01

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Catalyst-free synthesis of aminothiazole derivatives in water