Investigating the effect of adaptogens on anxiety and stress ; a systematic review study
Subject Areas : general Psychology
Keywords: Adaptogens, anxiety, fatigue, stress ,
Abstract :
Abstract: Introduction: Adaptogens are a group of plants known for their innate ability to fortify the body's nervous system. They achieve this by influencing the hypothalamus-pituitary-adrenal axis, regulating cortisol secretion (stress hormone) and enhancing endorphin production. By bolstering the body's resilience against fatigue, adaptogens hold promise in improving the overall quality of life. However, it is imperative to substantiate their efficacy through rigorous scientific investigation, thereby fostering tranquility and enhancing societal well-being. Consequently, this study aims to examine the impact of utilizing plant adaptogens on three key phenomena: anxiety, stress, and fatigue. Method: The current study takes the form of a comprehensive systematic review, where an assortment of trials and studies were meticulously gathered using well-defined search terms. These were sourced from both internal and external databases, with a particular emphasis on article titles. The inclusion criteria encompassed articles published in either English or Farsi between the years 2000 to 2023. Moreover, the focus primarily revolved around the clinical trial aspect. Additionally, the articles selected for analysis were those that involved a combined intervention of chemical medicine. To aid in the screening and management of resources, EndNote version 7 software was employed diligently. Findings: Out of the 2707 pertinent articles, a meticulous examination led to the inclusion of 27 fully qualified articles in this study. The comprehensive evidence substantiates the efficacy of botanical adaptogens in bolstering performance, enhancing the body's resilience against fatigue, and fostering mental well-being in the face of stress. Conclusion: By affording appropriate opportunities for the utilization of these plants in the human diet or medicinal formulations, a significant stride is taken towards enhancing the collective mental well-being of society
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Panossian A. Understanding adaptogenic activity: specificity of the pharmacological action of adaptogens and other phytochemicals. Ann N Y Acad Sci 2017;1401:49e64. https://doi.org/10.1111/nyas.13399
Nair R, Sellaturay S, Sriprasad S. The history of ginseng in the management of erectile dysfunction in ancient China (3500-2600 BCE). Indian J Urol 2012;28:15e20. https://doi.org/4103/0970-1591.94946
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Panossian A.G, Efferth, T, Shikov A.N., Pozharitskaya O.N, Kuchta K, Mukherjee P.K., Banerjee S, Heinrich M, Wu W, Guo D, et al. Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress and aging related diseases. Med. Res. Rev. 2020; 41: 630–703. https://doi.org/1002/med.21743
Tabachnik B. Adaptogensdnatural protectors of the immune system, potentiating health and the crisis of the immune system. Springer; 1997: 143e7. https://doi.org/10.1007/978-1-4899-0059-3_13
Christiansen, What are adaptogens? Ayurvedic herbs claimed to promote anti-aging and anti-stress, Verywell Health [Internet]. Available from: https://www.verywellhealth.com/what- are- adaptogens- 4685073}toc- what- arethe- benefits- of- adaptogens; 2022 . https://doi.org/10.1016/j.hsr.2023.100092
Shahinfar J, Zeraati H, Nasimi F, Shojaei S. [Effect of medicinal plants on anxiety]. Journal of Islamic and Iranian Traditional Medicine. 2017; 8(2):209-22. URL: http://jiitm.ir/article-1-859-en.html
Kalin NH. The critical relationship between anxiety and depression. The American Journal of Psychiatry. 2020; 177(5):365-7. https://doi.org/10.1176/appi.ajp.2020.20030305
World Health Organization. Mental health: Facing the challenges, building solutions [Internet]. 2005. Available from: https://www.euro.who.int/en/health topics/noncommunicable-diseases/mental- health /publications/2005/mental-health-facing-the-challenges,-building-solutions
Salve J, Pate S, Debnath K, et al.Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study. Cureus, 2019; 11(12): e6466. DOI 10.7759/cureus.6466. https://doi.org/10.7759/cureus.6466
Amin GR, Bozorgi M, Khatamsaz M, Khalaj A, Zolfaghari B, Rahimi R, etal. [Gāvzabān (Persian)]. Journal of Islamic and Iranian Traditional Medicine. 2017; 8(1):139-45. http://jiitm.ir/article-1-851-fa.html
PageJ, McKenzie J, Bossuyt P.M, Boutron I, Hoffmann T.C, Mulrow C.D, Shamseer L, Tetzlaff J.M, Akl E, Brennan S. et al. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ 2021; 372: 71. https://doi.org/10.1136/bmj.n71
Saiiah Bargard M, Assadi SM, Amini H, Saiiah M, Akhondzadeh Sh, Kamalinejad M. [Efficacy of aqueous extract of Echium amoenum L. in the treatment of mild to moderate major depressive disorder: A randomized double blind clinical trial (Persian)]. Journal of Medicinal Plants. 2014;2(10):61-8. http://jmp.ir/article-1-749-en.html. Or dor/20.1001.1.2717204.2004.3.10.9.7
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