The Effect of High Intensity Interval Training and Boswellia Supplementation on the Level of Inflammatory Cytokines and Brain-Derived Neurotrophic Factor in the Hippocampal Tissue of Old Rats

Subject Areas : Journal of Animal Biology

Jafar Qorbani ¹ , Reza Attarzadeh Hosseini ² , Amir Rashidlamir ^{3 *} , Mohammad Mosaferi Ziaodini ⁴

1 - Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad.
2 - Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad.
3 - Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad.
4 - Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad.

Received: 2024-07-22 Accepted : 2024-09-30 Published : 2025-01-12

Keywords: Aging, Interval training, Frankincense (Boswellia), Neuronal inflammation, Neurotrophic factor,

Abstract :

Today, sports activity and the consumption of plants with antioxidant properties are considered as modulators of aging inflammation for the prevention and treatment of inflammation-related diseases. The purpose of this research was to investigate the effect of high intensity interval training and frankincense (Boswellia) supplementation on the level of inflammatory cytokines and brain-derived neurotrophic factor in the hippocampal tissue of aged rats. The statistical sample of the study included 28 aged male Wistar rats who were divided into four groups: interval training + placebo, interval training + Boswellia supplement, Boswellia supplement and sham. High intensity interval training on a treadmill was performed five days a week for six weeks. Supplemental groups received 50 mg frankincense solution (per kilogram of body weight) by gavage during the intervention period. After anesthesia, a necropsy was performed and the levels of TNF-α, IL-6, and BDNF in the hippocampal tissue were measured. The results showed that according to the Kruskal-Wallis analysis, the difference between the ranks of the levels of TNF-α, IL-6 and BDNF in the hippocampus tissue of aged male rats was not statistically significant (p > 0.05). As a result, it seems that high intensity interval training and Boswellia supplement cannot cause a significant difference on the levels of inflammatory cytokines and Brain-derived neurotrophic factor in the hippocampus tissue.

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