Investigating the Epigenetic Role of lncRNAs in Patients with Diffuse B-cell Lymphomas

Subject Areas : Journal of Animal Biology

Milad Shahsavari ¹ , Sedigheh Arbabian ² , ّFarzaneh Hosseini ³ , محمدرضا رضوی ^{4 *}

1 - Department of Biology, North Tehran Branch, Islamic Azad University, Tehran, Iran
2 - Department of Biology, North Tehran Branch, Islamic Azad University, Tehran, Iran
3 - Department of Microbiology, Islamic Azad University, Tehran North Branch Tehran, Iran
4 - Microbiology Research Center, 69 Pasteur Avenue. 1316943551 Tehran, Iran

Received: 2023-12-03 Accepted : 2024-01-01 Published : 2025-01-12

Keywords: Lymphoma, DLBCL, Epigenetics, Cancer,

Abstract :

Diffuse large B-cell lymphoma (DLBCL) is a type of lymphoma that accounts for approximately 25-35% of all non-Hodgkin's lymphomas. The standard treatment for DLBCL is the R-CHOP regimen, which increases the five-year overall survival of patients, but 30–50% of patients do not respond to this therapy. Recently, a novel combination of lenalidomide plus R-CHOP has been investigated for the treatment of DLBCL. Recent studies have pointed to the potential impact of epigenetic changes in the occurrence and development of most cancers, especially DLBCL. In this study, the expression changes of two lncRNAs in patients with DLBCL were bioinformatically investigated and the relationship between the lncRNAs HOXA Transcript at the Distal Tip and Plasmacytoma Variant Translocation 1 was examined, and their impact on related signaling pathways was carefully evaluated. Finally, we showed the proteins that interact with both lncRNAs using Venn diagrams. In this study, the expression level of lncRNA in patients with DLBCL was bioinformatically analyzed and the results showed that the HOXA Transcript At The Distal Tip and Plasmacytoma Variant Translocation 1 genes were upregulated. These results can be useful in gene expression research and molecular alterations.

 

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