Effect of P-cymene on Chronic Immobilization-induced Oxidative Stress in Testis of Adult Male Rats

Subject Areas : Journal of Animal Biology

Yasaman Peirovy ¹ , masoumeh aslerousta ²

1 - Nanobiotechnology Research Center, Zanjan Branch, Islamic Azad University, Zanjan, Iran
2 - Department of Physiology, Zanjan Branch, Islamic Azad University, Zanjan, Iran

Received: 2024-03-03 Accepted : 2024-04-27 Published : 2024-08-06

Keywords: P-cymene, Testis, Oxidative stress, Chronic immobilization, Rat,

Abstract :

Chronic immobility is considered a stress that damages various body organs by inducing oxidative stress. In the study, the effect of the monoterpene p-cymene on oxidative stress induced by chronic immobility was investigated in the testes of adult male Wistar rats. Forty rats were divided into four groups (10 rats each) control, cymene, stress, and stress-cymene. The stress and stress-cymene groups were placed in the restrainer for 2.5 hours every day for 14 consecutive days. Cymene and stress-cymene groups also received p-Simon (50 mg/kg) intraperitoneally during the same period. At the end of the course, the levels of malondialdehyde, glutathione, the activity of superoxide dismutase, and glutathione peroxidase enzymes were measured in the testicles of the animals. The level of malondialdehyde in the stress-cymene group was significantly lower (P < 0.01), while the level of glutathione was higher in this group compared to the stress group (P < 0.05). The activity of superoxide dismutase and glutathione peroxidase showed a significant increase in the stress-cymene group compared to the stress group (P < 0.001). It is concluded that p-cymene can reduce the oxidative stress caused by chronic immobility in the testes of rats and possibly has therapeutic potential for testicular dysfunction.

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