Effects of Alcoholic Extract of Artemisia inflorescence on Wound Healing of Diabetic Wistar Rats

Subject Areas : Journal of Animal Biology

F. Harasani ¹ , Gh. Vaezi ^{2 *} , Vida Hojati ³

1 - Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
2 - Department of Biology, Tehran Science and Research Branch, Islamic Azad University, Tehran, Iran
3 - Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran

Received: 2017-01-06 Accepted : 2017-02-28 Published : 2018-05-22

Keywords: Mouse, Wound, Alcoholic extract of Artemisia diabetes, Skin ulcers,

Abstract :

Skin ulcers and diabetic foot ulcers are an important issue in medicine. Diabetes is one of the most common metabolic diseases of the endocrine system. Artemisia pharmacological, particularly effects on diabetes. The aim of this study was to compare the healing effects of alcoholic extract of Artemisia in the process of healing and skin wounds in normal and diabetic rats is quickly closing. Overall, 20 adult male Wistar rats were used. The rats were divided into four groups of five controls (without diabetes and treatment), sham (diabetes treatment Eucerin), Experimental 1 (diabetes without treatment), Experimental 2 (diabetes treated with alcoholic extract of Artemisia) were divided. Three groups of rats were made diabetic using STZ. Over 2 cm wound on the skin of spinous were created in all groups. The experimental group and the experimental group 2 with wormwood extract 1 Eucerin day with a dose of 100 mg Barba topical treatment over a period of 21 d, respectively. Wound healing was evaluated by macroscopic and microscopic. Wound healing in experimental groups 1 and 2 was treated with than the alcoholic extract of Artemisia control group showed the highest rate. Wormwood extract leads to topical wound healing in diabetic rats and material contained in Artemisia cause, faster wound contraction, and the healing.

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