Evaluating the Effect of Coenzyme Q10 (CoQ10) on Fertility, Depression, and Anxiety in Male Rats

Subject Areas : Journal of Animal Biology

Maryam Sharafi chie ¹ , Ramin Hajikhani ² , Jalal Solati ³ , Maryam khosravi ⁴

1 - 1- Department of Biology, North Tehran Branch, Islamic Azad University, Tehran, Iran
2 - 1- Department of Biology, North Tehran Branch, Islamic Azad University, Tehran, Iran
3 - 2- Department of Biology, Gohardasht Branch, Islamic Azad University, Karaj, Iran
4 - Department of Biology, North Tehran Branch, Islamic Azad University, Tehran, Iran

Received: 2019-07-07 Accepted : 2019-11-05 Published : 2020-02-20

Keywords: Depression, Fertility, Oxidative stress, Free radical, Quenzim Q10 (CoQ10),

Abstract :

Quenzim Q10 (CoQ10) is a benzoquinone compound soluble in androgen lipid found in most tissues of the body. CoQ10 has a potent antioxidant activity and neutralizes free radicals. The aim of this study was to investigate the effect of CoQ10 as a potent antioxidant and free radicals neutralizer on reproductive disorders, sexual behaviors, anxiety, and depression in male rats. In this study, small male rats (weight range of30-35 g) were used. At first, the animals under study passed a two-week treatment period. The adult male rats were treated with doses of 200, 300, 400 mg/kg of CoQ10 for two weeks. Then the effects of the given treatment were studied in the physiologic section. After the end of the treatment period, the sexual behaviors were assessed in the control group and treated groups by sexual behavior test. Then, the anxiety and depression levels in adult male rats were assessed using EPM and forced swimming tests, respectively. The findings of this study showed that the prescription of CoQ10 alone did not have a significant effect on sexual behaviors, depression, and anxiety in male rats.

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