The Effect of Eight Weeks of Aerobic Resistance Training on LXR Gene Expression and Serum TNFα Levels in CABG Patients

Subject Areas : Journal of Animal Biology

Fahimeh Parhizi ¹ (Department of Physical Education and Sport Sciences, Islamic Azad University, Neyshabour Branch, Neyshabour, Iran)
Amir Rashidlamir ² (Associate Professor, Ph.D. in Biochemistry and Exercise Metabolism, Faculty of Physical Education and Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran)
Rambod khajei ³ (Associate Professor, Department of Exercise Biochemistry and Metabolism, Faculty of Physical Education and Sport Sciences, Islamic Azad University of Mashhad, Mashhad, Iran)
Mohammd Reza Ramzanpour ⁴ (Associate Professor, Department of Exercise Biochemistry and Metabolism, Faculty of Physical Education and Sport Sciences, Islamic Azad University of Mashhad, Mashhad, Iran)
Mohsen Vazifehdoost ⁵ (Department of Food Science and Industries, Islamic Azad University, Neyshabour Branch, Neyshabour, Iran)

Received: 2019-07-26 Accepted : 2019-12-03 Published : 2020-02-20

Keywords: LXR, TNFα, Aerobic resistance training, Cardiac rehabilitation,

Abstract :

Cardiovascular diseases are one of the leading causes of death in the world. According to the American Heart Association, the prevalence of the cardiovascular diseases has an inflammatory basis, and general inflammation plays a central role in the development of atherosclerosis. The purpose of this study was to investigate the effect of eight weeks of aerobic resistance training on LXR gene expression and serum TNFα levels in CABG patients. Twenty-four men who underwent bypass surgery were voluntarily selected and randomly divided into experimental (n=12) and control (n=12) groups. The experimental group performed aerobic resistance training for eight weeks (3 sessions per week) and the control group did not. Blood samples were taken 48 hours before the start of the first training session and also 48 hours after the last training session while all subjects fated. Independent and paired samples Student's t-test and Shapirovilk test were used to normalize the data at a significant level of 0.05. The results of the present study showed that the training group experienced a significant increase in LXR mRNA gene expression and a decrease in serum TNFα levels as a result of eight weeks of aerobic resistance training compared to the control group. The same changes were seen as the within group differences in the pre-test and post-test in the training group. The findings of this study showed that an eight-week combined aerobic and resistance training program could regularly increase the LXR gene expression and decrease serum TNFα levels in CABG patients

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