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Manuscript ID : ASCIJ-2311-1564 (R1) Visit : 223 Page: 263 - 276

10.22034/ascij.2023.2002124.1564

Article Type: Original Research

The Effect of 12 Weeks of Intermittent Resistance Training with Algomed Supplementation on Plasma Levels of Asprosin and Omentin-1 in Men with Obesity

Subject Areas : Journal of Animal Biology

Arezou Bajelani 1 (Department of Physical Education and Sports Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran)
Hossein Abednatanzi 2 (Department of Physical Education and Sports Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran)
Farshad Ghazalian 3 (Department of Physical Education and Sports Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran)

Received: 2023-09-27 Accepted : 2023-12-02 Published : 2024-02-20

Keywords: Resistance training, Obesity, Chlorella vulgaris, Adipokine, Algomed,

Abstract :

Obesity is one of the main causes of death in developing countries, especially in Iran.  The aim of this study was to investigate the effect of 12 weeks of interval resistance training with Algomed (Chlorella vulgaris) supplement on asprosin and omentin-1 in obese men. 44 obese men will be divided into four groups of 11 people: control, exercise, supplement and supplemental exercise. Subjects in the 12-week training group will perform three sessions of resistance training sessions a week. Also, the subjects of the supplement group of 1800 mg Algomed Algae in the form of 6 tablets (2 tablets one and a half hour before breakfast, 2 tablets one and a half hour before lunch, 2 tablets one and a half hour before dinner) (according to the instructions factory) consumed. Blood was drawn 48 hours before the start of the research and 48 hours after the last day of training, and the mentioned indicators were measured using an ELISA kit and device. The results of the present study showed that there is a significant difference between the groups (p < 0.05). Bonferroni's post hoc test showed that training and supplement training caused an increase in omentin-1 and a decrease in asprosin compared to the control and supplement group (p < 0.05). The present results showed that interval resistance training alone and with algomed supplementation decreased the levels of asprosin and increased omentin-1 in obese men. Also, consumption of algomed along with interval resistance training compared to interval resistance training alone had a greater effect on the levels of the investigated variables.

References:


  1. Akbulut T., Cinar V., Ugur K., Yardim M., Karagoz Z., Aydin S. 2022. Effect of regular exercise on the levels of subfatin and asprosin: a trial with different types of exercise. European Review for Medical and Pharmacological Sciences, 26(8):2683-2691.
    2.
  2. Balistreri C.R., Caruso C., Candore G. 2010. The role of adipose tissue and adipokines in obesity-related inflammatory diseases. Mediators of Inflammation, 2010:802078.
    3.
  3. Brzycki M. 1993. Strength testing—predicting a one-rep max from reps-to-fatigue. Journal of Physical Education, Recreation and Dance, 64(1):88-90.
    4.
  4. Castro C.A., Silva K.A., Rocha M.C., Sene-Fiorese M., Nonaka K.O., Malavazi I. 2019. Exercise and omentin: their role in the crosstalk between muscle and adipose tissues in type 2 diabetes mellitus rat models. Frontiers in Physiology, 9:1881.
    5.
  5. De Souza Batista C.M., Yang R.Z., Lee M.J., Glynn N.M., Yu D.Z., Pray J. 2007. Omentin plasma levels and gene expression are decreased in obesity. Diabetes, 56(6):1655-1661.
    6.
  6. Gerst F., Wagner R., Oquendo M.B., Siegel-Axel D., Fritsche A., Heni M. 2019. What role do fat cells play in pancreatic tissue? Molecular Metabolism, 25:1-10.
    7.
  7. Gharanei S., Shabir K., Patel V., Brown J, Kyrou I., Randeva H. 2022. editors. Asprosin exerts pro-inflammatory effects via the TLR4 pathway in THP-1 macrophages. Endocrine Abstracts, 2022:86 P60.
    8.
  8. Görgens S.W., Eckardt K., Jensen J., Drevon C.A., Eckel J. 2015. Exercise and regulation of adipokine and myokine production. Progress in Molecular Biology and Translational Science, 135:313-336.
    9.
  9. Greulich S., Chen W.J., Maxhera B., Rijzewijk L.J., van der Meer R.W., Jonker J.T. 2013. Cardioprotective properties of omentin-1 in type 2 diabetes: evidence from clinical and in vitro studies. PloS one, 8(3):e59697.
    10.
  10. Halabis M, Dziedzic M, Warchulinska J, Kaznowska-Bystryk I, Solski J. 2015. Omentin-a new adipokine with many roles to play. Current Issues Pharmacy and Medical Sciences, 28(3):176-180.
    11.
  11. Hoffmann J.G., Xie W., Chopra A.R. 2020. Energy regulation mechanism and therapeutic potential of asprosin. Diabetes, 69(4):559-566.
    12.
  12. Hong T., Li J.Y., Wang Y.D., Qi X.Y., Liao Z.Z., Bhadel P. 2021. High Serum Asprosin Levels Are Associated with Presence of Metabolic Syndrome. International Journal of Endocrinology, 2021:6622129.
    13.
  13. Karbalamahdi A., Abedi B., Fatolahi H., Pazoki A. 2019. Effect of aerobic training and C. vulgaris intake on lipid profile and leptin in obese women. Hormozgan Medical Journal, 23(2):e91436-e.
    14.
  14. Lad N., Murphy A.M., Parenti C., Williams N.C., Nelson C.P., Sharpe G.R., et al., editors. 2022. The effect of novel adipokine asprosin on mitochondrial function in human airway epithelial cells. Endocrine Abstracts; 2022:86

  15. Lee H.S., Kim M.K. 2009. Effect of Chlorella vulgaris on glucose metabolism in Wistar rats fed high fat diet. Journal of Medicinal Food, 12(5):1029-1037.
    16.
  16. Lee T., Yun S., Jeong J.H., Jung T.W. 2019. Asprosin impairs insulin secretion in response to glucose and viability through TLR4/JNK-mediated inflammation. Molecular and Cellular Endocrinology, 486:96-104.
    17.
  17. Lestari P.H.P., Nurahmi N., Esa T., Kurniawan L.B. 2021. Omentin-1 Levels in Obesity. Indonesian Journal of Clinical Pathology and Medical Laboratory, 28(1):22-25.
    18.
  18. Molaei Jeghanab M., Gholami M., Banaeifar A., Ghazalian F. 2022. The effect of eight weeks resistance training along with vitamin D consumption on levels of chemerin and omentin-1 in type 2 diabetic patients. Metabolism and Exercise, 2(2):129-149.
    19.
  19. Moreno-Navarrete J.M., Catalán V., Ortega .F, Gómez-Ambrosi J., Ricart W., Frühbeck G. 2010. Circulating omentin concentration increases after weight loss. Nutrition and Metabolism, 7(1):1-6.
    20.
  20. Nakhaei H., Nayebifar S., Fanaei H. 2022. Decrease in serum asprosin levels following six weeks of spinning and stationary cycling training in overweight women. Hormone Molecular Biology and Clinical Investigation. 44(1):21-26.
    21.
  21. Noguchi N, Konishi F, Kumamoto S, Maruyama I, Ando Y, Yanagita T. 2013. Beneficial effects of Chlorella on glucose and lipid metabolism in obese rodents on a high-fat diet. Obesity Research and Clinical Practice, 7(2):e95-e105.
    22.
  22. Ouerghi N, Fradj MKB, Duclos M, Bouassida A, Feki M, Weiss K, 2022. Effects of High-Intensity Interval Training on Selected Adipokines and Cardiometabolic Risk Markers in Normal-Weight and Overweight/Obese Young Males. A Pre-Post Test Trial. Biology, 11(6):853.
    23.
  23. Pan H.Y., Guo L., Li Q. 2010. Changes of serum omentin-1 levels in normal subjects and in patients with impaired glucose regulation and with newly diagnosed and untreated type 2 diabetes. Diabetes Research and Clinical Practice, 88(1):29-33.
    24.
  24. Panagiotou G., Triantafyllidou S., Tarlatzis B.C., Papakonstantinou E. 2021. Serum levels of irisin and omentin-1 in breast neoplasms and their association with tumor histology. International Journal of Endocrinology, 2021:6656671.
    25.
  25. Pirani H., Roustaie M., Ravasi A.A., Lamir A.R. 2022. Effects of 8-week high-intensity interval training and continuous aerobic training on asprosin secretion and fibrillin-1 gene expression levels in diabetic male rats. International Journal of Diabetes in Developing Countries, 2022:1-6.
    26.
  26. Rani K., Sandal N., Sahoo P. 2018. A comprehensive review on chlorella-its composition, health benefits, market and regulatory scenario. The Pharma Innovation Journal, 7(7):584-589.
    27.
  27. Romere C., Duerrschmid C., Bournat J., Constable P., Jain M., Xia F. 2016. Asprosin, a fasting-induced glucogenic protein hormone. Cell, 165(3):566-579.
    28.
  28. Sakurai T., Izawa T., Kizaki T., Ogasawara J.E., Shirato K., Imaizumi K., 2009. Exercise training decreases expression of inflammation-related adipokines through reduction of oxidative stress in rat white adipose tissue. Biochemical and Biophysical Research Communications, 379(2):605-609.
    29.
  29. Salminen A., Kaarniranta K., Kauppinen A. 2016. Age-related changes in AMPK activation: role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways. Ageing Research Reviews, 28:15-26.
    30.
  30. Sanayei M., Kalejahi P., Mahinkazemi M., Fathifar Z., Barzegar A. The effect of Chlorella vulgaris on obesity related metabolic disorders: a systematic review of randomized controlled trials. Journal of Complementary and Integrative Medicine, 19(4):833-842.
    31.
  31. Sanayei M., Izadi A., Hajizadeh-sharafabad F, Amirsasan R, Kaviani M, Barzegar A. 2021. Chlorella vulgaris in combination with high intensity interval training in overweight and obese women: a randomized double-blind clinical trial. Journal of Diabetes and Metabolic Disorders, 2021:1-12.
    32.
  32. Sanayei M., Izadi A., Hajizadeh-Sharafabad F., Amirsasan R., Kaviani M., Barzegar A. 2021. Chlorella vulgaris in combination with high intensity interval training in overweight and obese women: a randomized double-blind clinical trial. Journal of Diabetes and Metabolic Disorders, 20(1):781-792.
    33.
  33. Schäffler A., Neumeier M., Herfarth H., Fürst A., Schölmerich J., Büchler C. 2005. Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue. Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression, 1732(1-3):96-102.
    34.
  34. Shafeie A.A., Tahmasebi W., Azizi M. 2019. The simultaneous effects of Chlorella vulgaris supplementation and high intensity interval training on IL-6 serum levels reduction and insulin resistance on overweight men. Journal of Neishabour University of Medical Sciences,7(3):75-88.
    35.
  35. Shibata S., Hayakawa K., Egashira Y., Sanada H. 2007. Hypocholesterolemic mechanism of Chlorella: Chlorella and its indigestible fraction enhance hepatic cholesterol catabolism through up-regulation of cholesterol 7α-hydroxylase in rats. Bioscience, Biotechnology, and Biochemistry, 71(4):916-925.
    36.
  36. Strasser B., Schobersberger W. 2011. Evidence for resistance training as a treatment therapy in obesity. Journal of Obesity, 2011:482564.
    37.
  37. Tan B.K., Adya R., Farhatullah S., Lewandowski K.C., O’Hare P., Lehnert H. 2008. Omentin-1, a novel adipokine, is decreased in overweight insulin-resistant women with polycystic ovary syndrome: ex vivo and in vivo regulation of omentin-1 by insulin and glucose. Diabetes, 57(4):801-808.
    38.
  38. Ugur K., Erman F., Turkoglu S., Aydin Y., Aksoy A., Lale A. 2022. Asprosin, visfatin and subfatin as new biomarkers of obesity and metabolic syndrome. European Review for Medical and Pharmacological Sciences, 26(6):2124-2133.
    39.
  39. Unamuno X., Gómez‐Ambrosi J., Rodríguez A., Becerril S., Frühbeck G., Catalán V. 2018. Adipokine dysregulation and adipose tissue inflammation in human obesity. European Journal of Clinical Investigation, 48(9):e12997.
    40.
  40. Wang Y., Qu H., Xiong X., Qiu Y., Liao Y., Chen Y. 2018. Plasma asprosin concentrations are increased in individuals with glucose dysregulation and correlated with insulin resistance and first-phase insulin secretion. Mediators of Inflammation, 2018:9471583.
    41.
  41. Wang C.Y., Lin T.A., Liu K.H., Liao C.H., Liu Y.Y., Wu V.C. 2019. Serum asprosin levels and bariatric surgery outcomes in obese adults. International Journal of Obesity, 43(5):1019-1025.
    42.
  42. Watanabe T., Watanabe‐Kominato K., Takahashi Y., Kojima M., Watanabe R. 2011. Adipose tissue‐derived omentin‐1 function and regulation. Comprehensive Physiology, 7(3):765-781.
    43.
  43. Wilms B, Ernst B, Gerig R, Schultes B. 2015. Plasma omentin-1 levels are related to exercise performance in obese women and increase upon aerobic endurance training. Experimental and Clinical Endocrinology and Diabetes, 123(03):187-192.
    44.
  44. Yamawaki H., Tsubaki N., Mukohda M., Okada M., Hara Y. 2010. Omentin, a novel adipokine, induces vasodilation in rat isolated blood vessels. Biochemical and Biophysical Research Communications, 393(4):668-672.
    45.
  45. Yang R.Z., Lee M.J., Hu H., Pray J., Wu H.B., Hansen B.C. 2006. Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. American Journal of physiology-endocrinology and Metabolism, 290(6):E1253-E1261.
    46.
  46. Zabetian-Targhi F., Mirzaei K., Keshavarz S.A., Hossein-Nezhad A. 2016. Modulatory role of omentin-1 in inflammation: cytokines and dietary intake. Journal of the American College of Nutrition, 35(8):670-678.
    47.
  47. Zatterale F., Longo M., Naderi J., Raciti G.A., Desiderio A., Miele C. 2020. Chronic adipose tissue inflammation linking obesity to insulin resistance and type 2 diabetes. Frontiers in Physiology, 10:1607.
    48.
  48. Zehsaz F., Farhangi N., Ghahramani M. 2016. The response of circulating omentin-1 concentration to 16-week exercise training in male children with obesity. The Physician and Sportsmedicine, 44(4):355-361.
    49.
  49. Zengi S., Zengi O., Kirankaya A, Kucuk SH, Kutanis EE, Yigit O. 2019. Serum omentin-1 levels in obese children. Journal of Pediatric Endocrinology and Metabolism, 32(3):247-251.
    50.

Zhao A., Xiao H., Zhu Y., Liu S., Zhang S., Yang Z. 2022. Omentin-1: a newly discovered warrior against metabolic related diseases. Expert Opinion on Therapeutic Targets, 26(3):275-289.

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