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Manuscript ID : ASCIJ-2302-1466 (R1) Visit : 262 Page: 83 - 101

10.22034/ascij.2023.1979751.1466

Article Type: Original Research

The Effect of 12 Weeks of Continuous and Interval Training on some Adipokines, Hepatokines and Insulin Resistance in Type 1 Diabetic Rats

Subject Areas : Journal of Animal Biology

Mohammad salmasi 1 (Department of exercise Physiology and Corrective exercise, Faculty of Sports Sciences, Urmia University, Urmia, Iran)
Mohammad reza zolfaghari 2 (Department of exercise Physiology and Corrective exercise, Faculty of Sports Sciences, Urmia University, Urmia, Iran)
Akbar Nouri Habashi 3 (Department of exercise Physiology and Corrective exercise, Faculty of Sports Sciences, Urmia University, Urmia, Iran)

Received: 2023-02-08 Accepted : 2023-08-21 Published : 2023-11-22

Keywords: Insulin resistance, Aerobic training, type 1 diabetes, interval training,

Abstract :

Diabetes is considered as one of the most developed diseases in the world and one of the main causes of death. One of the ways to prevent diabetes and its complications is to exercise in different ways. The aim of this study was to compare the effect of 12 weeks of continuous and interval training on fetuin b, fetuin a and glypican 4 plasma and insulin resistance in type 1 diabetic rats.For this purpose, 40 type 1 diabetic mice were divided into 4 groups: healthy control, diabetes control, continuous diabetes, and diabetes interval. The interval group performed six repetitions per session by running on the treadmill in 3-minute intervals at a speed of 20 meters per minute and active recovery at a speed of 10 meters per minute with a 0% incline for 3 minutes on the treadmill (total duration of 36 minutes). The continuous training group also ran at a speed of 15 meters per minute for 36 minutes with a slope of 0%. Rats were killed 48 hours after the last training session and blood sampling was done. To compare between groups, one-way ANOVA and Bonferroni's post hoc test were used. Examining changes between groups showed that there is a significant difference between groups for insulin resistance, fetuin b, fetuin a and glypican 4 plasma (P<0.001). Examination of between groups changes showed that insulin resistance, fetuin b, fetuin a, and glypican 4 plasma had a significant decrease in the healthy group compared to the diabetic group (P<0.001). Also, there was a significant difference between the diabetes control group and the continues and interval groups in all indicators (P<0.001). The results of the present study showed that interval and continuous exercise can reduce plasma fetuin b, fetuin a and glypican 4 in type 1 diabetic rats. These improvements were better in the interval training group than in the continuous training group.

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