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Manuscript ID : ASCIJ-2109-1301 (R1) Visit : 423 Page: 197 - 207

10.22034/ascij.2022.1939160.1301

Article Type: Original Research

Protective Effect of Magnesium Sulfate against Experimental Models of Gastric Ulcer in NMRI Mice

Subject Areas : Journal of Animal Biology

Roya Rostami 1 (Department of Biology, Islamic Azad University, Science and Research Branch, Tehran, Iran)
Akram Eidi 2 (Department of Biology, Islamic Azad University, Science and Research Branch, Tehran, Iran)
Pejman Mortazavi 3 (Department of Pathology, Faculty of Specialized Veterinary Sciences, Islamic Azad University, Science and Research Branch, Tehran, Iran)
Shahrebano Oryan 4 (Department of Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran)

Received: 2021-09-03 Accepted : 2021-11-10 Published : 2022-08-23

Keywords: antioxidant enzyme, ethanol, NMRI mice, Gastric ulcer, magnesium sulfate,

Abstract :

Gastric ulcers are common digestive disorders involving stomach mucosal lesions with worldwide prevalence. There are different reasons for peptic ulcers. One common reason among west societies is ethanol consumption. The aim of the present study is pretreatment by magnesium sulfate. In this study 66 male NMRI mice were randomly divided into 11 groups and the administered mice were followed up daily for 15 days. These groups include control group (intact), control ulcer group (ethanol 10 mg/kg), standard group (omeprazole 40 mg/kg and ethanol), experimental groups (magnesium sulfate 50, 100, 200, 300 mg/kg), and experimental ulcer groups (magnesium sulfate 50, 100, 200, 300 mg/kg and ethanol). At the end of the relevant period, the levels of oxidative stress parameters were biochemically evaluated. The results of this study revealed that the activity of catalase, glutathione peroxidase and superoxide dismutase in control ulcer group significantly decreased compared to the control group. Oral administration of magnesium sulfate produced no significant effect on catalase, glutathione peroxidase and superoxide dismutase activities in intact animals. Animals in experimental ulcer groups represented a great increase in catalase, glutathione peroxidase, and superoxide dismutase levels over the treatment by magnesium sulfate. Moreover, our results showed that the amount of malondialdehyde in control ulcer group was significantly increased compared to the control group. Pre-treatment with magnesium sulfate caused no significant change on the amount of malondialdehyde in control group, while the level of malondialdehyde was considerably decreased in experimental ulcer groups. Furthermore, our results demonstrated that a pretreatment with MgSO4 could notably reduce oxidative stress and gastric lesions.  

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