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Manuscript ID : ASCIJ-2208-1410 (R2) Visit : 338 Page: 105 - 118

10.22034/ascij.2023.1964676.1410

Article Type: Original Research

The Effect of Risperidone on the Induction of Psychological Dependence and the Number of Hippocampal Neurons in Adult Male Rats

Subject Areas : Journal of Animal Biology

Zahra Mansouriarani 1 , Nasrin Heydariyeh 2 , Hamid Reza Banafshe 3 , Gholamreza Ghavipanjeh 4 , Majid Lotfinia 5

1 - Department of Biology, Qom Branch, Islamic Azad University, Qom, Iran
2 - Department of Biology, Qom Branch, Islamic Azad University, Qom, Iran
3 - Department of Pharmacology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
4 - Department of Pharmacology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
5 - Department of Biotechnology, Physiology Research Center Basic Sciences Research Institute, Kashan University of Medical Sciences, Kashan, Iran

Received: 2022-09-14 Accepted : 2023-01-08 Published : 2023-08-23

Keywords: Risperidone, Psychological Dependence, Neuron, Hippocampus,

Abstract :

Psychological dependence on substances is the desire to consume substances or something that has pleasurable effects and produces satisfaction. Various substances cause this dependence. Previous studies indicate the possible effect of risperidone on the brain reward system and the involvement of different receptors in conditioned place preference (CPP). Therefore, the present study was designed with the aim of investigating the effect of risperidone on the induction of psychological dependence and the number of hippocampal neurons. For this study, 40 male Wistar rats with a weight range of 230-280 grams were used. Risperidone was injected intraperitoneally with doses of 1, 2 and 4 mg/kg. At the end of the hippocampus experiments, the animals were taken out and fixed by formalin, then cut and after staining, they were used for histological evaluation and neuronal counting. The results of this study showed that the administration of risperidone with a dose of 2 and 4 mg/kg causes a significant increase in CPP (p < 0.05). Also, in histological evaluation, no neuronal destruction was observed in all risperidone groups (1, 2 and 4 mg/kg). According to the obtained results, it can be concluded that risperidone in higher doses causes an increase in conditioned place preference and learning and dependence and should be considered in treatment.

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