The Effect of Aerobic Training before and after Induction of Alzheimer's Disease on Memory and Learning of Amyloid Beta-Infected Alzheimer's Disease Rats

Subject Areas : Journal of Animal Biology

Farahnaz Amir Shaghaghi ¹ (Department of Exercise Physiology, Faculty of Physical Education, University of Tehran, Tehran, Iran.)
Zahra Izanloo ² (Department of Motor Behavior, Department of Sport Science, Faculty of Human Science, University of Bojnurd, Bojnurd, Iran)
Malihe Naeimikia ³ (Department of Motor Behavior, Sport Sciences Research Institute, Tehran, Iran.)

Received: 2021-09-30 Accepted : 2022-01-22 Published : 2022-11-22

Keywords: Aerobic exercise, Dementia, Amyloid beta,

Abstract :

Alzheimer's disease is a progressive neurological disorder that leads to loss of nerve cells and impaired memory and learning. This study aims at investigating the effect of an aerobic exercise course before and after Alzheimer's disease induction on memory and learning of amyloid beta-infected Alzheimer's disease rats. Sixty Wistar rats with a mean weight of 195±17.20 g were obtained from the Pasteur Institute of Iran in the pre-Alzheimer's disease induction stage. After two weeks, the rats were randomly divided into two equal groups of control (30 heads) and experiment (30 heads). After four weeks of training, the rats in each group were divided into three subgroups: 1. Amyloid beta injection 2. Placebo injection 3. No injection. The rats in the Alzheimer's disease groups got Alzheimer's disease by injecting Aβ1-42 into the hippocampus. The aerobic exercise protocol was five days a week for four weeks. 24 hours after the last training session, rats' memory and learning were assessed by using the Morris water maze test. Data was analyzed by one-way and two-way ANOVA. Significance between variables was considered at the level of P ≤ 0.05.The results of studying the learning and memory in different groups revealed that exercise groups showed better results than other groups in both Alzheimer's disease rats and healthy rats after a training period before and after Alzheimer's disease induction (P ≤ 0.05). Many studies have shown that physical activity and exercise may improve cognitive function and delay the onset of AD and other diseases associated with dementia. These results are supported by several studies that have shown that physical activity reduces the levels of AD-related factors. .

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