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Manuscript ID : ASCIJ-2001-1133 (R1) Visit : 371 Page: 75 - 86

Article Type: Original Research

The Effect of Eight Weeks of Aerobic Resistance Training on ABCG8 Gene Expression and Lipid Profile in CABG Patients

Subject Areas : Journal of Animal Biology

Farida Sadeghi Fazel 1 , Amir Rashidlamir 2 , Rambod Khajeie 3 , Akbar Safipour Afshar 4

1 - 1. Department of Exercise Physiology, Faculty of Humanities, Islamic Azad University, Neyshabour Branch, Neyshabour, Iran
2 - Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
3 - Department of Exercise Physiology, Faculty of Humanities, Islamic Azad University, Neyshabour Branch, Neyshabour, Iran
4 - 3. Department of Biology, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran

Received: 2020-07-26 Accepted : 2020-10-30 Published : 2021-02-19

Keywords: Lipid profile, CABG patients, Aerobic resistance training, ABCG8 gene,

Abstract :

Coronary heart disease is one of the leading causes of death in today's societies. It is associated to the exercise activity and the expression of some genes involved in the blood cholesterol transmission. Adenosine triphosphate-dependent box protein 8 is a member of ABC transporter family which plays a key role in the metabolism of high-density lipoprotein cholesterol and cholesterol. This study aimed to evaluate the effect of eight weeks of aerobic resistance training on ABCG8 gene expression and lipid profile in CABG patients. 30 men with CABG patients voluntarily selected and randomly divided into the experimental (n = 15) and control (n = 15) groups. The experimental group performed the aerobic resistance training for eight weeks (3 sessions per week) and the control group did not. Blood samples were taken 48 h before the first training session and 48 h after the last training session, while all subjects were fasting. Independent and paired t-test used to analyze the data at a significant level of 0.05. The present study's results showed that the aerobic resistance training group showed a significant increase in the ABCG8 mRNA expression and a significant decrease in LDL-C, triglyceride, and HDL-C as compared to the control group. Due to the findings of present study, it can be concluded that aerobic resistance training by increasing ABCG8 gene expression has a great effect on increasing the cholesterol transfer process; thus, it may improve the CABG patients and prevent cardiovascular diseases.

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