The Effect of Aerobic-resistance Training on HIF1a Gene Expression in Coronary Artery Disease After CABG

Subject Areas : Journal of Animal Biology

Azar Hamidi ¹ , Amir Rashidlamir ² , Rambod Khajei ³ , Mehdi Zarei ⁴ , Ahmad Zendedel ⁵

1 - Department of Physical Education, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran
2 - Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
3 - Department of Physical Education, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran
4 - Department of Physical Education and Sport Sciences, Faculty of Literature and Humanities, University of Neyshabur, Neyshabur, Iran
5 - Department of Statistics, Faculty of Basic Sciences, Neyshabur Azad University, Neyshabur, Iran

Received: 2019-10-26 Accepted : 2020-01-22 Published : 2021-02-19

Keywords: Aerobic resistance training, Cardiac rehabilitation, HIF1α, CABG,

Abstract :

Coronary heart disease (CAD) is one of the most important causes of death in most countries, including Iran. Post-operative exercise coronary artery bypass grafting (CABG), and its adaptations, increase skeletal and cardiac capillary density associated to developing new capillaries called angiogenesis and improve cardiovascular function and functional ability. This study aimed to investigate the effect of cardiac rehabilitation on HIF1- α gene expression in post-CABG coronary patients. The sample contained 30 men aged 45-60 years who underwent bypass surgery. They were randomly divided into experimental (n = 15) and control (n = 15) groups. The experimental group performed aerobic resistance training for eight weeks (3 sessions per week), and the control group did not. Blood samples were taken 48 hours before starting the first training session and 48 hours after the last training session, while all subjects were fasting. Independent and paired t-test and Shapirovilk test were used to analyze the data at a significant level of 0.05 in SPSS version 21. The results showed that the HIF-1α gene expression in the aerobic resistance group also increased in the control group which was statistically significant (p < /em> = 0.001) as well as before and after changes in the exercise group. The control group was significant (p < /em> = 0.001). Due to the findings of the present study, it can be concluded that combined (aerobic-resistance) exercises may increase cardiovascular function by increasing HIF1α-1 gene expression and the growth of new capillaries called angiogenesis and by increasing circulation. It improves patients' quality of life after CABG.

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