The Effect of Hydroalcoholic Extract of Ferulago angulata on Liver Function Tests and Some Biochemical Parameters in Adult Male Wistar Rats

Subject Areas : Journal of Animal Biology

Yasna Bidmeshki ¹ , Somayeh Bohlouli ²

1 - Department of Biology, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran
2 - Department of Veterinary, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran

Received: 2022-03-04 Accepted : 2022-07-09 Published : 2023-02-20

Keywords: Ferulago angulata, Biochemical parameters, liver, hydroalcoholic extract, Male wistar rats,

Abstract :

Many modern medicines are obtained from medicinal plants, and the properties of many of these plants have been confirmed and proven with new investigations. The purpose of this study is to investigate the effect of different doses of hydroalcoholic extract of Ferulago angulata on biochemical and hematological parameters orally on male Wistar rats. 28 heads of male Wistar rats that were randomly studied experimentally. Mice were divided into a control group without extract and groups receiving Ferulago angulata extract with doses of 50, 150 and 300 mg/kg. The treatment groups were conducted for 16 weeks. After the end of the test, serum glucose level, lipid profile including triglyceride, cholesterol, LDL, HDL, albumin, total protein and liver enzymes ALP, AST and ALT were measured. Different doses of Ferulago angulata extract changed the levels of some lipid factors and liver enzymes in the studied groups compared to the control group. Different doses of Ferulago angulata extract caused a significant decrease in the level of glucose, triglycerides and liver enzymes (AST and ALT), and the level of LDL. Also, the amount of albumin, HDL and total protein increased, and there was no change in the amount of cholesterol and ALP. The results of this study showed that Ferulago angulata plant has positive effects on some biochemical factors and liver function improvement despite its antioxidant compounds. Therefore, we can introduce Ferulago angulata plant as one of the most effective plants in the medicinal plant industry and treatment, control and prevention of many diseases.

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