Cytotoxicity Effects of Ammi visnaga Extract on Hela and MCF7 Cancer Cell Line vvررررررررررررررر

Subject Areas : Journal of Animal Biology

هدیه پاک فطرت ¹ (گروه زیست شناسی، واحد دامغان، دانشگاه آزاد اسلامی، دامغان، ایران)
فرخنده نعمتی ² (مرکز تحقیقات سلولی ـ مولکولی، گروه زیست شناسی، واحد قائم شهر، دانشگاه آزاد اسلامی، قائم شهر، ایران)
عبدالحسین شیروی ³ (گروه زیست شناسی، واحد دامغان، دانشگاه آزاد اسلامی، دامغان، ایران)

Received: 2015-01-27 Accepted : 2017-05-21 Published : 2015-01-21

Keywords: Cytotoxicity, Cancer cell lines, Ammi visnaga, Inhibitory effect vv,

Abstract :

The discovery of new materials such as anti-microbial and anti-viral and anti-cancer known among plants or those who have recently been discovered can help to treat diseases. In this study, the cytotoxic effect of plant extracts Ammi visnaga extract on Hela and MCF7 cell lines were analyzed. Different concentrations of ethanolic extract of the Ammi visnaga on cultured blood cells and cancer cell line for 72 hours were examined. The cytotoxicity was evaluated by MTT test. Results are reported as IC50. This study showed that different concentrations of Ammi visnaga extract have cytotoxic effect on Hela and MCF7 cell lines. The percentage of growth inhibition of Hela and MCF7 cells increasing whit whit increasing concentration of test compounds. IC50 value for Hela was 0.57 mg /ml, and for MCF7 was 2mg/ml. The results suggest that ethanolic extract of Ammi visnaga has inhibitory effect on cell growth of MCF7 and Hela cell lines. vv