Effects of Peritoneal injection of seed extract of Ipomoea violacea on fear behavior in male wistar rats.
Subject Areas : Journal of Animal Biologyالهام ابوالفضلی 1 , غلامحسن واعظی 2
1 - کارشناس ارشد بیولوژی جانوری دانشگاه آزاد اسلامی واحد دامغان
2 - استادیاردانشگاه آزاد اسلامی واحد دامغان
Keywords: Rat, ethanolic extract, fear, Ipomoea violacea seed, Elevated Plus-Maze, I.C.V, PTZ,
Abstract :
Morning Glory Seeds called tlitlitzin were used ritually by the Aztec for their psychoactive properties to communicate with the Sun Gods. Spanish chroniclers in the mid 16th century reported on the divinatory use of these seeds. Their use has continued in southern Mexico, although it wasnand#39;t until about 1900 that tlitlitzin was identified botanically as Morning Glory.In this research the effect of Ethanolic extract of Ipomoea violacea on fear behavior in the adult male rats. Research based on Intra cerebro ventricular (I.C.V) injection of amount (250,500,1000 andmu;g/rat) ethanolic extract of Ipomoea violacea and pentylenetetrazol (PTZ) with 20 mg/kg dose (I.P).In control group 1 andmicro;l of saline had been injected and in positive control group 20 mg/kg of pentylenetetrazol (PTZ) .Intra peritonealy (I.P) had been injected. Elevated Plus andndash; maze used for behavioral test. Results showed i.c.v injection of 1000 (andmu;g /rat ) in comparison with control group(saline) increased fear (p andlt; 0.05). Meanwhile have not any significant difference between all doses with positive control and saline control. showed i.c.v injection of 1000 (andmu;g/rat ) with 20 (andmu;g/rat) PTZ drug i.p injection in comparison with control group (saline) increased fear (p andlt; 0.05) and too showed i.c.v injection of 500 (andmu;g/rat ) in comparison with positive control group decrease fear (p andlt; 0.05). There are between 500 and 1000 (andmu;g/rat ) significant difference.Final this study confirm effective of ethanolic extract Ipomoea violacea seeds On fear behavior and interaction between extract with drug PTZ.