The Effect of Ecstasys Tablet on Passive Avoidance Learning and Memory
Subject Areas : Journal of Animal Biologyحمیده افتخاری 1 , فروزان کشاورز زاده 2
1 - دانشگاه آزاد اسلامی، واحد ارسنجان، گروه زیستشناسی، ارسنجان، ایران
2 - دانشگاه آزاد اسلامی، واحد ارسنجان، گروه زیست شناسی، ارسنجان، ایران
Keywords: Rat, Ecstasy, passive avoidance learning, Memory,
Abstract :
Today tendency to administration of nervous stimulating drugs is one of the problems of human societies. Ecstasy is a neurotoxin that drives from amphetamines. This substance can produce a depression of cell brain function and alteration in several neurotransmittes.This article focuses on the effect of this drug on passive avoidance learning and memory.In this research 40 vistar rat were divided into 5 group (n=8). Control groupreceived no drug. Sham group received serum as soluble of drug and 3 other groups were pretreated with 5, 10 and 20 mg/kg Ecstasy oral. After 22 days passive avoidance learning were surveyed with Shuttle box and step through latency (STL) and total (TLC) were measured. Results were investigated with ANOVA test. In all groups that received Ecstasy, STL and TLC significantly decresed in dose dependent manner (pandlt; 0.05). It is necessary to consider longer STL and TLC means better learning and memory. Results of this study shows that learning and memory deficits in Ecstasy users.