Effects of Aqueous Extracts of Purslane (Portulaca Oleracea) on Memorizing and Passive Avoidance Learning in Male Wistar Rats

Subject Areas : Journal of Animal Biology

حیدر آقابابا ¹ , فریبا جعفری شیبانی ² , حسین عباسپور ³

1 - دانشگاه آزاد اسلامی، واحد ارسنجان، گروه زیست شناسی، ارسنجان، ایران
2 - دانشگاه آزاد اسلامی، واحد ارسنجان، گروه زیست شناسی، ارسنجان، ایران
3 - دانشگاه آزاد اسلامی، واحد دامغان، گروه زیست شناسی، دامغان، ایران

Received: 2014-06-21 Accepted : 2017-05-21 Published : 2013-01-20

Keywords: Portulaca oleracea, passive avoidance learning, shuttle box, Memorizing, purslane, Wistar Rat,

Abstract :

Aqueous extract of purslane (Portulaca Oleracea) is a rich source of omega-3fatty acids that has a major role in the evolution of the brain and nervous system and increasing memory. Therefore in this study, effects of aqueous extract of purslane on passive avoidance learning and memory were investigated by measuring the amount of STL (delayed phase) in 40 male Wistar rats weighing 180 to 220 g. The Rats for a weektocompromise with theenvironment(In theheatof the21 andplusmn; 2anddeg; C, 12 hours lightand12 hoursdarkness)were keptin the animalandrsquo;sroom.Purslane purchased from herb shops, and then it was mill after drying and then its aqueous extract was used for examinations on Rats in the shuttle box unit. The One-Way Analysis of Variance to determine the mean and standard error for each group were performed and the Schaffer and Tukey tests for the statistical interpretations were used. Acceptable level for statistical analysis of mean difference, p andgt; 0.05 was considered. In this study, doses of 0.25, 0.5, and 1.0 mg/kg were used. The dose of 0.25 mg/kg was selected as the effective dose that would increase the levels of cortisol and the STL.