Effects of Lactobacillus casei Bacteria Killed by Chloroform on Cutaneous Wound Healing in Rats on Days 3 and 7
Subject Areas : Journal of Animal Biologyسیما مشایخ 1 , میترا حیدری نصرآبادی 2 , ویدا حجتی 3 , مریم تاج آبادی ابراهیمی 4
1 - دانشگاه آزاد اسلامی، واحد دامغان، گروه زیست‌شناسی دامغان، ایران
2 - دانشگاه آزاد اسلامی، واحد پرند، گروه زیست‌شناسی، پرند، ایران
3 - دانشگاه آزاد اسلامی، واحد دامغان، گروه زیست‌شناسی دامغان، ایران
4 - دانشگاه آزاد اسلامی، واحد تهران مرکز، گروه زیست‌شناسی، تهران، ایران
Keywords: Probiotic, Healing, skin ulcer, Lactobacillas casei,
Abstract :
Ulcer healing means to retrieve the whole physical internal and external structures which includes the complex interactions between different cells and factors- plenty of researchers has paid so much attention to shorten the time of healing just due to cost reduction and ulcer infection. They applied different ways to gain this goal so the basic aim of this research is to investigate the effects of cultivated Lactobacillas casei by chloroform on the Cutaneous woundhealing- we used 220-280 g rats- the rats were kept in 20andplusmn;2andCcedil; and food and water provided for the entirely then the rats were divided to five experimental- control and negative control groups. A quadrangle wound 1.5andtimes;1.5 was created. The control and experiment groups were treated topically oserin and the oserin contains cultivated Lactobacillus casei by chloroform but the negative control group has received no treatment rats skin ulcers in rats exposed to pathological sampling and statistical and histology surveying. Findings showed that there are significant differences between ulcer healing percentages of control and experimental groups and negative control. In next phases of healing in experimental group-comparing control and negative control group the number of notrofils reduced. According to findings Lactobacillus casei bacteria which cultivated in chloroform significantly result in decreasing inflammation and accelerating ulcer healing in rats.