The Effect of Ethanolic Extract of Quercus persica on Gastric Ulcer Healing in Rats
Subject Areas : Journal of Animal Biology
فهیمه مطیع
1
,
میترا حیدری نصرآبادی
2
,
عبدالحسین شیروی
3
,
فریما زاهدی
4
1 - دانشگاه آزاد اسلامی، واحد دامغان، گروه زیست شناسی، دامغان، ایران
2 - دانشگاه آزاد اسلامی، واحد پرند، گروه زیست شناسی، پرند، ایران
3 - دانشگاه آزاد اسلامی، واحد دامغان، گروه زیست شناسی، دامغان، ایران
4 - دانشگاه آزاد اسلامی، واحد پرند، گروه زیست شناسی، پرند، ایران
Keywords: Healing, ethanolic extract, Gastric ulcer, Quercus persica,
Abstract :
Today there is great interest in using traditional medicine for ulcer healing has been increased.Quercus persica is used in Iranian traditional medicine to treat some gastric diseases. The present study was undertaken to evaluate the Quercus persica ethanolic extract for gastric ulcer healing in rats. Extractedfrom theskin of oakfruit soakedin90%ethanoland extractswere measuredby therotarydevice. To determine the effect of this extract from Quercus persica, 56 wistar male rats divided into 2 groups; experimental and control (n=7).Gastric ulcers were induced by luminal application of 0.12 ml acetic acid solution (40% v/v). One day after ulcer induction, the experimental groups Ethanolic extract of Quercus persica at concentration 100 mg/kg w.b.and the control groups received 1 ml normal salin through oral gavage for few consecutive days. On days 1, 3, 5 and 7 rats were killed and wound samples were collected for histological and statistical studies. Results analysis by one way Anova demonstrated that ethanolextract ofthe fruitskinof Quercus persica at concentration 100 mg/kg w.b.significantly increased gastric ulcer area compared to control group and decreased ulcer healing. Also, inflammation cells such as neutrophil and macrophage in the third and fifth days in the experimental groups compared with control groups had significantly increased, which is prolonged inflammation stage.On the seventh day, in the experimental groups a significant reduction in the amount of fibroblast was seen that indicates the delay in wound healing and collagen-synthesis process.The current study showedsignificant increase of inflammation and decrease wound healinginrats treated with ethanolextract ofthe fruitskinof Quercus persica at concentration 100 mg/kg w.b.as compared to control group