The Protective Effects ofSalvia officinalisExtractonthe PancreaticTissueofRatsPoisonedbyDiazinon

Subject Areas : Journal of Animal Biology

اسماعیل فتاحی ¹ , آنا خشکفا ²

1 - گروه زیست شناسی، واحد آیت ا... آملی، دانشگاه آزاد اسلامی، آمل، ایران
2 - گروه تربیت بدنی، واحد آیت ا... آملی، دانشگاه آزاد اسلامی، آمل، ایران

Received: 2015-12-19 Accepted : 2017-05-21 Published : 2015-10-23

Keywords: diazinon, pancreas, Salvia officinalis, Langerhans Island,

Abstract :

Diazinon is organophosphates that causes inhibition of acetylcholinesterase and induceofoxidative stress intheorganismThisstudy was done todeterminethe effects ofSalvia officinalisextractonpancreatictissueinratspoisonedbydiazinon.This experimental study, 35 adult male rats were divided into three equal groups;control, Diazinon(DZN), Diazinon-extractAnimals in experimental groups,were received anintraperitoneal injection of 200 mg/kg DZNfor one time and extractat dose of 100 mg / kg for four weeks(five days per week).Rats were sacrificed24 h after latest injection. Pancreatictissuesections were provided to microscopic studies.  Data were analyzed using of one-way ANOVA.Number and diameter ofIslets of Langerhans and Blood vesselsand number of acini cells in the DZN group sig­nificantly decreasedcompared to the control(pSalvia officinalisextracthaveprotective effect on pancreatic.