The Protective Effects ofSalvia officinalisExtractonthe PancreaticTissueofRatsPoisonedbyDiazinon
Subject Areas : Journal of Animal Biology
اسماعیل فتاحی
1
(
گروه زیست شناسی، واحد آیت ا... آملی، دانشگاه آزاد اسلامی، آمل، ایران
)
آنا خشکفا
2
(
گروه تربیت بدنی، واحد آیت ا... آملی، دانشگاه آزاد اسلامی، آمل، ایران
)
Keywords: diazinon, pancreas, Salvia officinalis, Langerhans Island,
Abstract :
Diazinon is organophosphates that causes inhibition of acetylcholinesterase and induceofoxidative stress intheorganismThisstudy was done todeterminethe effects ofSalvia officinalisextractonpancreatictissueinratspoisonedbydiazinon.This experimental study, 35 adult male rats were divided into three equal groups;control, Diazinon(DZN), Diazinon-extractAnimals in experimental groups,were received anintraperitoneal injection of 200 mg/kg DZNfor one time and extractat dose of 100 mg / kg for four weeks(five days per week).Rats were sacrificed24 h after latest injection. Pancreatictissuesections were provided to microscopic studies. Data were analyzed using of one-way ANOVA.Number and diameter ofIslets of Langerhans and Blood vesselsand number of acini cells in the DZN group significantly decreasedcompared to the control(pSalvia officinalisextracthaveprotective effect on pancreatic.