Investigation of the Level of Serum Troponin I and Comparing it with Serum CK-MB in Diagnosis of Myocardial Infarction

Subject Areas : Journal of Animal Biology

جمال شمسی ¹ , پریچهره یغمایی ² , میرحسین سید محمدزاده ³ , سید علی حائری روحانی ⁴

1 - گروه زیست شناسی، واحد علوم تحقیقات تهران، دانشگاه آزاد اسلامی، تهران، ایران
2 - گروه زیست شناسی، واحد علوم تحقیقات تهران، دانشگاه آزاد اسلامی، تهران، ایران
3 - دانشکده علوم پزشکی, مرکز آموزشی درمانی سیدالشهدا ارومیه، بخش قلب و عروق، ارومیه، ایران
4 - گروه زیست شناسی، واحد علوم تحقیقات تهران، دانشگاه آزاد اسلامی، تهران، ایران

Received: 2015-08-23 Accepted : 2017-05-21 Published : 2015-07-23

Keywords: eCG, Myocardial Infarction, Troponin I, CK-MB.  ,

Abstract :

The Myocardial infarction (MI) is the fail in reaching blood flow and sufficient oxygen to part of the heart. Te outbreak of MI symptoms might be various and the electrocardiography is not diagnostic in about 50% of the cases that is a potential danger for wrong diagnosis, therefore we need to test the cardiac biomarkers. In this survey the level of Troponin I serum in the diagnosis of the cardiac infarction with CK-MB serum, in 40 MI patients and 40 cardiac patients without MI of Seyyed Al Shohada Heart Hospital in Urmia has been evaluated and compared. the Troponin I through Immunoenzymometric method using AccuBind Kit and CK-MB through DGKC (German Society of Clinical Chemistry) method and IFCC (International Federation of Clinical Chemistry) using Pars Azmun Company kit through photometric method, measurement. and then Conducted  the results' statistical analysis using SPSS 21 software and an independent T-test The results achieved from the comparison between the cTnI and CK-MB of MI patients and patients without MI showed that there was a significant difference between the cTnI of patients without MI and MI patients and also the CK-MB of patients without MI and MI patients at the level of (P) and the cTnI and CK-MB of MI patients is more than patients without MI. therefore their use is necessary for on time diagnosis and treatment of Myocardial infarction. In this survey the cTnI and CK-MB was compared from the viewpoint of sensitivity and specification that regarding the results the cTnI sensitivity and specification with 100% and 97.5% respectively was more than the CK-MB sensitivity and specification with 91% and 75% respectively.