The Effects of Fe2ZnO4 Nanoparticles on Blood Cells of Male Wistar Rat

Subject Areas : Journal of Animal Biology

A. Gerami ¹ , M. Setorki ² , Z. Hooshmandi ³

1 - گروه زیست شناسی، واحد سنندج، دانشگاه آزاد اسلامی، سنندج، ایران
2 - گروه زیست شناسی، واحد ایذه، دانشگاه آزاد اسلامی، ایذه، ایران
3 - گروه زیست شناسی، واحد سنندج، دانشگاه آزاد اسلامی، سنندج، ایران

Received: 2016-10-15 Accepted : 2017-05-21 Published : 2016-11-21

Keywords: lymphocyte, hematocrit, Fe2ZnO4, Neutrophil, Platelet,

Abstract :

Due to increased production and use of nanoparticles, extensive studies are needed to determine their toxicity and negative effects. The aim of this study was to evaluate the effect of Fe2ZnO4 nanoparticle on blood cell counts and hematocritpercentage. In this experimental study, 24 male Wistar rats were randomly divided into groups of 8 rats. Group 1 received 0.5 ml of saline. Group 1 and 2 received 0.5ml of distillated water containing 100 and 200 ppm Fe2ZnO4for 7 successive days. Red blood cell count, white blood cell count and differential count, platelet count and hematocrit were determined 2, 7 and 14 days after treatment. Fe2ZnO4 lead to a significant reduction in RBC and a significant increase in WBC. Nanoparticles exposure increased neutrophil and lymphocyte percentage which reflects the heightened response of innate immune system against nanoparticles. Fe2ZnO4 also caused a significant reduction in blood platelet count and 200 ppm dose caused higher reduction (p