HistologicalStudy of the Effect of Ethanol on the Injured Tendon in Rat
Subject Areas : Journal of Animal Biology
1 - گروه پزشکی، واحد شاهرود، دانشگاه آزاد اسلامی، شاهرود، ایران
Keywords: ethanol, Rat, Histology, Tendon, Tenocyte,
Abstract :
Ethanolhas a suppressive effect on inflammation and immune responses and its impact has been studied in different regions of the body. But there is no useful information about ethanol effects on tendon structure. The aim of this study was to evaluate the histological effects of ethanol on rat tendon is injured.Twenty rats were randomly divided in two groups: ethanol and control. The amount of ethanol in combination with glucose in the drinking water of rats was gradually increased and was also used by them. After one week of use, the Achilles tendon of rats at each junction of the calcaneus injury was induced. In the fourth week, all rats were sacrificed and the injured tendon samples were collected and were examined histologically. Ethanol-induced increases Tenocyte with abnormal morphology, disruption and irregular collagen fibers toward increasing the number of Tenocyte and neovascularization was 3 weeks after tendon injury.Tendon in the ethanol group than the control group did not have any healing or improvement. The results of this study showed that ethanol causes delayed healing and tendon reformation.