Synthesis, Characterization and Biological Activities of Metal (II) Dipicolinate Complexes Derived From Pyridine-2, 6-Dicarboxylic Acid and Tris (2-Aminoethyl) Amine

Subject Areas : The Application of Chemistry in Environment

Received: 2015-01-29 Accepted : 2015-03-01 Published : 2016-01-21

Keywords: Antimicrobial Activity, Pyridine-2, 6-Dicarboxylic Acid, Tris(2-Aminoethyl) Amine, Metal (II) Complex,

Abstract :

The new water-soluble and airstable compounds (tren) [Co(dipic)2]. 6H2O(1), (tren) [Ni(dipic)2].6H2O(2) and  (tren) [Zn(dipic)2].6H2O(3) were prepared by the reaction of corresponding metal (II) chloride, nitrate, sulfate and a proton transfer salt ,(tren)(Hdipic)2,(4)of pyridine -2,6 -dicarboxylic acid (H2dipic) and tris(2-aminoethyl)amine (tren). the compounds 1-3 were characterized by elemental, IR, UV-vis, thermal analyses, magnetic measurement studies.The molecular structures of the title compounds consist of one (tren)3+cation , one bis(pyridine-2,6-dicarboxylate) metal (II) [M(dipic)2]2- anion , and six  uncoordinated water molecules . In compounds 1-3 the metal ions coordinate to two oxygen and one nitrogen atoms of two pyridine -2,6 - dicarboxylate  molecules forming an octahedral environment . Antimicrobial activities against Gram (-) wild type (Escherichia coli and Pseudomonas aeruginosa),Gram(+) wild type (Staphylococcus aureus, Staphylococcus epidermidis, Bacillus cereus and Bacillus subtilis ) and clinical isolate (Morganella morganii, Proteus vulgaris and Enterobacter aeruginisa) were also studied. MIC (Minimal Inhibition Concentration) values of the newly synthesized compounds were determined as 4000 µg/ml (expect B. subtilis and clinical isolate E. aeruginosa , >4000 µg/ml).