The synthesis of quinoxaline compounds using iron (III) phosphate as an environmentally catalyst
Subject Areas : The Application of Chemistry in Environment
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Abstract :
The synthesis of quinoxaline compounds using iron (III) phosphate as a catalyst is reported. The studies on the synthesis of new quinoxaline derivatives have been of considerable importance becauses of their interesting chemical as well as biological properties. Quinoxaline derivatives are widely distributed in nature and many of them, such as the antibiotics, levomycin and actinomycin possess very useful biological activity. In addition, a large number of synthetic quinoxalines have also shown antibacterial, fungicidal, insecticidal, anti-inflammatory, tranquilizing and antidepresant properties. In this paper, the synthesis of quinoxaline derivatives is reported from the reaction of benzyl derivatives or α-hydroxy ketones and 1,2phenylenediamine using FePO4 as a green, none toxic and environmentally catalyst in ethanol under reflux condition.
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