Efficient Copper-catalyzed Cyanation of Aryl Bromides Using 1,3-phenylene-bis-(1H)-tetrazole as an Efficient Ligand

Subject Areas : The Application of Chemistry in Environment

Received: 2012-12-16 Accepted : 2013-01-09 Published : 2013-05-22

Keywords: 1, Aryl Nitrile, 3-Phenylene-bis-(1H)-Tetrazole, Aryl Bromide, Cyanation, K4Fe(CN)6, Copper Acetate,

Abstract :

A New Method for the Synthesis of Aryl Nitriles Has Been Developed by the Cyanation of Aryl Bromides with K4Fe(CN)6as A Cyanide Source In The Presence Of Cu(Oac)2.H2O As An Inexpensive Catalyst And A 1,3-Phenylene-Bis-(1H)-Tetrazole Ligand. This Method Has The Advantages Of High Yield, Simple Methodology And Easy Work-Up.