Glutamic Acid Activity As A Natural and Green Organocatalyst For The Synthesis of 2, 3-Dihydroquinazolin-4 (1H)-One Derivatives Under Solvent-Free Conditions
Subject Areas : The Application of Chemistry in Environment
Keywords: Solvent-free, Glutamic acid, 2, Ecofriendly, 3-Dihydroquinazolin-4 (1H)-one derivatives,
Abstract :
Quinazolinones have been extensively contained a broad range of biological and pharmacological activities. Because, in this work, we reported the synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives from the reaction between anthranilamide and aldehydes under solvent-free conditions in the presence of an amino acid named glutamic acid as a natural, ecofriendly, inexpensive, and nontoxic catalyst. In addition to, this methodology offers several advantages such as the purification, easy, methods, excellent yields, short reaction time, easy access and mild reaction conditions.
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