The Synthesis Investigation of (3-(4-Nitro Phenyl ) Isoxazol-5-Yl) Methanol in the Presence of Tio2 Nano Particles

Subject Areas : The Application of Chemistry in Environment

Received: 2015-10-07 Accepted : 2015-11-07 Published : 2016-04-20

Keywords: Isoxazole- oxime- nano particles,

Abstract :

Isoxazole  and  isoxazolines  are very useful  heterocycles  in  organic  medicinal chemistry . Isoxazoline rings have been used by organic chemists for synthetic manipulation to aceess complex molecular  architectures. drugs such as Isocarboxazid , valdecoxib , oxacillin, leftunomide and micafiungin are the examplesto substantiate the pharmaceutical acceptance of such heterocyclic systems. [1] This research work  describes  the  synthesis  of  new compound of  isoxazole  family. First 4-nitro benzaldehyde (1) was transformed to 4-nitro  benzaldoxime (2) by using  NH2OH  in pyridine . The in  situ generated  nitriloxide  from reaction between (2) and  NaOCl, was  reacted  with  propargylalcohol  in the presence of  TiO2  nano particles  By the increasing  of  nano particles the yield of compounds was  increased . The  structure of all the synthesised  compounds  was  characterized and confirmed by FT-IR  and NMR spectroscopy  techniques.