HClO4-SiO2as an Efficient and Reusable Heterogeneous Catalyst for the Synthesis of 1-substituted Tetrazoles

Subject Areas : The Application of Chemistry in Environment

Received: 2012-11-27 Accepted : 2012-12-17 Published : 2013-05-22

Keywords: Primary Amines, Heterogeneous catalyst, 3, 2, HClO4-SiO2, Triethyl Orthoformate, 1-Substituted 1H-1, 4-Tetrazole,

Abstract :

An Efficient and Direct Protocol is Described for the Preparation of 1-Substituted 1H-1,2,3,4-Tetrazoles by the Reaction of Primary Amines, Triethyl Orthoformate and Sodium Azide in the Presence of Catalytic Amount of Silica-Supported Perchloric Acid Under Solvent-free and heterogeneous conditions. The thermal solvent-free green procedure offers advantages such as simple methodology, easy work-up, high yield, recovery and reusability of catalyst.