Studying the Antifungal effect of Hydroalcoholic extracts of three species of Medicinal plants from the growing areas of Meshgin Shahr against Clinical isolates of Candida Albicans.

Subject Areas : The Application of Chemistry in Environment

Hojjat Eghbal ¹ , Mehdi Ahmadi Sabegh ² , Neda Jahani ³ , Yousef Jahani Jelodar ⁴

1 - Department of Phytochemistry, Basic Sciences Research Center, Tabriz University, Iran.
2 - Assistant Professor of Organic Chemistry, Department of Chemistry, Faculty of Basic Sciences, Islamic Azad University, Ahar Branch, Ahar, Iran.
3 - . Doctor of General Dentistry, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4 - 4. Researcher of Agricultural and Horticultural Research Department of Agricultural Research and Education Center and Natural Resources of Ardabil Province, Agricultural Research, Education and Extension Organization, Ardabil, Iran.

Received: 2022-10-16 Accepted : 2023-04-08 Published : 2023-01-21

Keywords: Candida albicans, Disc diffusion, hydroalcoholic extract, Anti-Fungus,

Abstract :

Method: dual mixture of Pune-Peppermint extract, Pune-Sourberry, Sour-Peppermint and Triple Blend of Hydroalcoholic extract of Pune, Peppermint and Sorghum used. The extracts were diluted with propylene glycol and in addition to pure extracts, concentrations of 10, 20, 30, 40 and 50 mg / ml of extract were prepared. To study the effect of hydroalcoholic extracts of Pune, Mint and Sour and Dual Blend Triticale extracts of these three plants were used to grow Albicans candidate by antibiotic and MIC methodsResults: The results of this study showed that the triple mixture of Puneh, Mint and Savange extracts with a concentration of 50 mg / ml with a diameter of 32.2 mm had the highest diameter of the inhibition zone and the hydroalcoholic extract Peppermint at a concentration of 10 mg per milliliter with a diameter of 7 mm halo assigns the lowest diameter of the non-growth zone of Candida albicans. Also, the triple mixture of Puneh, Mint and Souri showed relatively similar results to fluconazole antibiotics.Conclusion: The results of the minimum inhibitory concentration showed that the lowest inhibitory concentration was related to the antibiotic fluconazole and the triple mixture of hydroalcoholic extract of Punea, Mint and Sardinia, and the lowest was the hydroalcoholic extract of Mint herb.