One-Pot Multicomponent Synthesis of Chromeno-Pyrido-Pyrimidinones Using Zirconium-Based Heterogeneous Catalyst
Subject Areas : Chemistry and Chemical Engineering of all specializationsfatemeh khojaste 1 , Nahid Shajari 2 * , Parvin Eskandari 3 , Mohammad Reza Farahpour 4 , Hooriye Yahyaei 5
1 - Department of Chemistry, Za.C., Islamic Azad University, Zanjan, Iran
2 - Department of Chemistry, Za.C., Islamic Azad University, Zanjan, Iran
3 - Department of Chemistry, Za.C., Islamic Azad University, Zanjan, Iran
4 - Department of Clinical Sciences, Faculty of Veterinary Medicine, Ur.C., Islamic Azad University, Urmia, Iran
5 - Department of Chemistry, Za.C., Islamic Azad University, Zanjan, Iran
Keywords: Multicomponent Reactions, Heterogeneous Catalyst, Pyrido-Pyrimidines, Green Synthesis,
Abstract :
In this study, an efficient and green method for the synthesis of 7-Aryl, Chromeno[4,3-d] Pyrido [1,2-a] Pyrimidin-6-ones using the heterogeneous catalyst ZrO(NO3)2.2H2O is presented. This approach involves a one-pot multicomponent reaction among hydroxycoumarin, aromatic benzaldehydes, and 2-amino pyridine in ethanol solvent. The results demonstrate high yields and catalyst efficiency within a short reaction time. The synthesis mechanism includes protonation and complex reactions such as condensation and Michael addition, leading to the production of compounds with desirable biological properties. This method not only reduces the steps in synthesis but also aligns green chemistry principles by employing environmentally friendly catalysts, moving closer to sustainability goals in organic chemistry. Overall, this study introduces an effective and sustainable strategy for synthesizing heterocyclic compounds that can serve as a replacement for existing synthetic methods
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