The effect 8 weeks resistance training on PTP1B expression in Gastrocnemius muscle, insulin resistance and fasting glucose in type 2 diabetic rats

Subject Areas : Effect of Physical Activity on Diseases

amin  boroomand ¹ (staff)
babisan  askari ² (Assistant Professor, Department of Physical Education and Sport Sciences, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran.)
Saqqa  Farajtabar Behrestaq ³ (Assistant Professor, Department of Physical Education and Sport Sciences, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran)
Amir  Taghipour ⁴ (Assistant Professor, Department of Physical Education and Sport Sciences, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran.)

Received: 2022-12-25 Accepted : 2023-02-10 Published : 2023-05-22

Keywords: Type 2 diabetes, Keywords: Resistance training, Gastrocnemius muscle, PTP1B expression,

Abstract :

AbstractBackground and Purpose: This experimental study aimed to determine the effect of 8 weeks resistance training on PTP1B expression in gastrocnemius muscle, glucose and insulin resistance in Wistar male's rats with type 2 diabetes. Material and Methods: The population consisted of all rats, among which 14 were purchased 10-weeks old rats with a 220 ± 20 g weighing. Then, type 2 diabetes induced by 8 weeks high-fat diet + STZ and divided randomly into resistance training and control groups. Then, the resistance rats participated in 8 weeks resistance training for 5 sessions per week. Fasting glucose, serum insulin and PTP1B expression in gastrocnemius muscle of both groups were measured at 48 hours after last exercise and compared between 2 groups by independent T test. Results: The resistance training improved fasting glucose compared with control subjects. Insulin resistance was significantly increased and PTP1B expression in gastrocnemius muscle significantly decreased in resistance group when compared with control subjects. Conclusion: Based on these data, decreased glucose concentration in exercise group can be attributed to decrease PTP1B expression in gastrocnemius muscle in response to resistance training.Keywords: Resistance training, Gastrocnemius muscle, Type 2 diabetes, PTP1B expression.