Recent advances in ISFET-based biosensors for the detection of biomarkers: History, principles, gate structure and applications
Subject Areas : Nano Biophotonics
Seyed Saman Nemati
1
,
Gholamreza Dehghan
2
,
Yaser Abdi
3
,
Sohrab Ahmadi-Kandjani
4
1 - Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
2 - University of Tabriz, Tabriz,Iran
3 - Nanophysics Research Laboratory, Department of Physics, University of Tehran, 1439955961 Tehran, Iran
4 - Research Institute for Applied Physics and Astronomy (RIAPA), University of Tabriz, Tabriz, Iran
Keywords: ISFET sensor, Gate materials, Biosensor, Enzymatic ISFET assay, Biomarkers.,
Abstract :
The use of ion-sensitive field effect transistor (ISFET) sensors is one of the most prominent methods of signal detection and measurement for various analytes and biomarkers. Here the history of the ISFET sensors and their general operations are reviewed. The gate materials and structures, because of the extreme importance of gate performance and structure in sensitivity, price, reusability, durability, and stability of ISFET sensors, have been the subject of many studies. In addition, the importance of gate materials in ISFET sensor readout methods is reviewed here. The applications of ISFET as super biosensors with high sensitivity, easy manufacturing methods, sufficient stability, and cost-effectiveness in the measurement of ions, DNA, biomarkers, and analytes based on enzyme activity, are highlighted. Finally, the importance and advantage of using ISFET sensors with bioactive nanomaterial layers are emphasized, and future studies of these sensors, based on our point of view, are discussed.
References:
[1] A. Shinde, K. Illath, U. Kasiviswanathan, S. Nagabooshanam, P. Gupta, K. Dey, et al. “Recent Advances of Biosensor-Integrated Organ-on-a-Chip Technologies for Diagnostics and Therapeutics,” Analytical Chemistry, vol. 95, pp. 3121-3146, 2023.
[2] F. Ghasemi and A. Salimi, “Advances in 2D Based Field Effect Transistors as Biosensing Platforms: From Principle to Biomedical Applications,” Microchemical Journal, vol.187 pp.108432, 2023.
[3] K.S. Singh, P. Gupta, M. Rajoriya, N. Kumari, and A. Muskan, “Study of Tunnel Field Effect Transistors for Biosensing Applications: A Review,” International Conference on Computing, Communication, and Intelligent Systems (ICCCIS): IEEE, vol. 144, pp. 1-5, 2022.
[4] R. Jalili, A. Khataee, M-R. Rashidi, and A. Razmjou, “Detection of penicillin G residues in milk based on dual-emission carbon dots and molecularly imprinted polymers,” Food chemistry, vol. 314, pp. 126172, 2020.
[5] R. Shiwaku, H. Matsui, K. Nagamine, M. Uematsu, T. Mano, and Y .Maruyama, et al, “A printed organic amplification system for wearable potentiometric electrochemical sensors,” Scientific reports, vol. 8, pp. 3922 (1-8), 2018.
[6] M. Adampourezare, G. Dehghan, M. Hasanzadeh, and M-AH. Feizi, “Application of lateral flow and microfluidic bio-assay and biosensing towards identification of DNA-methylation and cancer detection: Recent progress and challenges in biomedicine,” Biomedicine & Pharmacotherapy, vol. 141, pp. 111845, 2021.
[7] H. Sohrabi, MR. Majidi, O. Arbabzadeh, P. Khaaki, S. Pourmohammad, A. Khataee, et al, “Recent advances in the highly sensitive determination of zearalenone residues in water and environmental resources with electrochemical biosensors,” Environmental Research, vol. 204, pp. 112082, 2022.
[8] T. Kuno, K. Niitsu, and K. Nakazato, “Amperometric electrochemical sensor array for on-chip simultaneous imaging,” Japanese Journal of Applied Physics, vol.53, pp. 04EL1, 2014.
[9] P. Bertoncello and R.J. Forster, “Nanostructured materials for electrochemiluminescence (ECL)-based detection methods: recent advances and future perspectives,” Biosensors and Bioelectronics, vol. 24, pp. 3191-3200, 2009.
[10] S. Rashtbari, G. Dehghan, S. Khataee, M. Amini, and A. Khataee, “Dual enzymes-mimic activity of nanolayered manganese-calcium oxide for fluorometric determination of metformin,” Chemosphere, vol. 291, pp. 133063, 2022.
[11] S. Rashtbari, G. Dehghan, and M. Amini, “An ultrasensitive label-free colorimetric biosensor for the detection of glucose based on glucose oxidase-like activity of nanolayered manganese-calcium oxide,” Analytica chimica acta, vol. 1110, pp. 98-108, 2020.
[12] B.A. Prabowo, A. Purwidyantri, and K-C. Liu, “Surface plasmon resonance optical sensor: A review on light source technology,” Biosensors, vol. 8, pp. 1-28, 2018.
[13] S. Cao, P. Sun, G. Xiao, Q. Tang, X. Sun, H. Zhao, Sh. Zhao, H. Lu, and Z. Yue, “ISFET‐based sensors for (bio) chemical applications: A review,” Electrochemical Science Advances, vol. 3, pp e2100207 (1-25), 2022.
[14] P. Bergveld, “Development of an ion-sensitive solid-state device for neurophysiological measurements,” IEEE Transactions on biomedical engineering, vol. 17, pp .70-71, 1970.
[15] Y. Su, W. Hsu, and CT. Lin, “Review field effect transistor biosensing: devices and clinical applications,” ECS J Solid State Sci Technol, vol.7, pp. Q3196 (1-7), 2018.
[16] W-S. Kao, Y-W. Hung, and C-H. Lin, “Solid-State Sensor Chip Produced with Single Laser Engraving for Urine Acidity and Total Dissolved Ion Detections,” ECS Journal of Solid State Science and Technology, vol. 9, pp. 115016, 2020.
[17] JT. Smith, SS. Shah, M. Goryll, JR. Stowell, and DR. Allee, “Flexible ISFET biosensor using IGZO metal oxide TFTs and an ITO sensing layer,” IEEE Sensors Journal, Vol. 14, pp. 937-938, 2013.
[18] T. Wadhera, D. Kakkar, G. Wadhwa, and B. Raj, “Recent advances and progress in development of the field effect transistor biosensor: A review,” Journal of Electronic Materials, vol. 48, pp. 7635-7646, 2019.
[19] AM. Dinar, AM. Zain, and F. Salehuddin, “Utilizing of CMOS ISFET sensors in DNA applications detection: A systematic review,” Jour Adv Res Dyn Control Syst. Vol. 10, pp. 569-583, 2018.
[20] L. Keeble, N. Moser, J. Rodriguez-Manzano, and P. Georgiou, “ISFET-based sensing and electric field actuation of DNA for on-chip detection: A review,” IEEE Sensors Journal, vol. 20, pp. 11044-11065, 2020.
[21] Y-C. Syu, W-E. Hsu, and C-T. Lin, “Field-effect transistor biosensing: Devices and clinical applications,” ECS Journal of Solid State Science and Technology, vol. 7, pp. Q3196, 2018.
[22] M. Wróblewska, “Miniaturized multiplexed bipotentiostat for field-effect transistor based biosensing: Katedra,” Biotechnologii Medycznej, 2023.
[23] JE. Lilienfeld and O. Heil, Transistor efek–medan. System.800:000.
[24] W. Shockley, “A unipolar field-effect transistor,” Proceedings of the IRE. Vol. 40, pp. 1365-1376, 1952.
[25] D. Kahng, “Silicon-silicon dioxide field induced surface devices," IRE Solid State Device Res Conf1960.
[26] Jr LC. Clark and C. Lyons, “Electrode systems for continuous monitoring in cardiovascular surgery,” Annals of the New York Academy of sciences, vol. 102, pp. 29-45, 1962.
[27] P. Bergveld, “Development, operation, and application of the ion-sensitive field-effect transistor as a tool for electrophysiology,” IEEE Transactions on Biomedical Engineering, vol. , pp. 342-351, 1972.
[28] K. Lundström, M. Shivaraman, and C. Svensson. “A hydrogen‐sensitive Pd‐gate MOS transistor,” Journal of Applied Physics, vol.46, pp. 3876-3881, 1975.
[29] S. Caras and J. Janata. “Field effect transistor sensitive to penicillin,” Analytical chemistry, vol. 52, pp. 1935-1937, 1980.
[30] L. Bousse, De. Rooij NF, and P. Bergveld, “Operation of chemically sensitive field-effect sensors as a function of the insulator-electrolyte interface,” IEEE Transactions on Electron Devices, vol. 30, pp. 1263-1270, 1983.
[31] J-i. Anzai, T. KUSANO, T. OSA, H. NAKAJIMA, T. MATSUO, “Urea sensor based on ion sensitive field effect transistor coated with cross-linked urease-albumin membrane,” Bunseki Kagaku, vol. 33, pp. E131-E136, 1984.
[32] Y. Miyahara, T. Moriizumi, and K. Ichimura, “Integrated enzyme FETs for simultaneous detections of urea and glucose,” Sensors and Actuators, vol. 7, pp. 1-10, 1985.
[33] BH. van der Schoot and P. Bergveld, “ISFET based enzyme sensors,” Biosensors, vol. 3, pp. 161-86, 1987.
[34] O. Boubriak, A. Soldatkin, N. Starodub, A. Sandrovsky, and A. El'skaya, “Determination of urea in blood serum by a urease biosensor based on an ion-sensitive field-effect transistor,” Sensors and Actuators B: Chemical, vol. 27, pp. 429-431, 1995.
[35] PB. Luppa, LJ. Sokoll, and DW. Chan, “Immunosensors—principles and applications to clinical chemistry,” Clinica chimica acta, vol. 314, pp. 1-26, 2001.
[36] DE. Yates, S. Levine, and TW. Healy, “Site-binding model of the electrical double layer at the oxide/water interface,” Journal of the Chemical Society, Faraday Transactions 1: Physical Chemistry in Condensed Phases, vol.70, pp. 1807-1818, 1974.
[37] AJ. Bard, LR Faulkner electrochemical methods, W iley, New York. 1980.
[38] A. Van den Berg, P. Bergveld, D. Reinhoudt, and E. Sudhölter, “Sensitivity control of ISFETs by chemical surface modification,” Sensors and Actuators, vol. 8, pp. 129-148, 1985.
[39] M. Yuqing, G. Jianguo, and C. Jianrong, “Ion sensitive field effect transducer-based biosensors,” Biotechnology advances, vol. 21, pp. 527-534, 2003.
[40] A. Simonis, T. Krings, H. Lüth, J. Wang, and MJ. Schöning, “A hybrid thin-film pH sensor with integrated thick-film reference,” Sensors, vol. 1, pp. 183-192, 2001.
[41] P. Bergveld, “Thirty years of ISFETOLOGY: What happened in the past 30 years and what may happen in the next 30 years,” Sensors and Actuators B: Chemical, vol. 88, pp. 1-20, 2003.
[42] R. Datar and G. Bacher, “Influence of Gate Material, Geometry, and Temperature on ISFET Performance in pH Sensing Applications,” Silicon, vol. 1, pp. 1-13, 2023.
[43] X. Ma, R. Peng, W. Mao, Y. Lin, and H. Yu, “Recent advances in ion‐sensitive field‐effect transistors for biosensing applications,” Electrochemical Science Advances, vol. , pp. e2100163, 2022.
[44] S. Honda, M. Shiomi, T. Yamaguchi, Y. Fujita, T. Arie, S. Akita, et al. “Detachable Flexible ISFET‐Based pH Sensor Array with a Flexible Connector,” Advanced Electronic Materials, vol. 6, pp. 2000583, 2020.
[45] J. Zhang, M. Rupakula, F. Bellando, E. Garcia Cordero, J. Longo, F. Wildhaber, et al. “Sweat biomarker sensor incorporating picowatt, three-dimensional extended metal gate ion sensitive field effect transistors,” Acs Sensors, vol. 4, pp. 2039-2047, 2019.
[46] H-J. Jang and W-J. Cho, “High performance silicon-on-insulator based ion-sensitive field-effect transistor using high-k stacked oxide sensing membrane,” Applied Physics Letters, vol. 99, pp. 043703, 2011.
[47] I-K. Lee, M. Jeun, H-J. Jang, W-J. Cho, and K. Lee, “A self-amplified transistor immunosensor under dual gate operation: highly sensitive detection of hepatitis B surface antigen,” Nanoscale, vol. 7, pp. 16789-16797, 2015.
[48] Y-H. Chang, Y-S. Lu, Y-L. Hong, S. Gwo, JA. Yeh, “Highly sensitive pH sensing using an indium nitride ion-sensitive field-effect transistor,” IEEE Sensors Journal, vol. 11, pp. 1157-1161, 2010.
[49] M. Myers, FLM. Khir, A. Podolska, GA. Umana-Membreno, B. Nener, M. Baker, et al. “Nitrate ion detection using AlGaN/GaN heterostructure-based devices without a reference electrode,” Sensors and Actuators B: Chemical, vol. 181, pp. 301-305, 2013.
[50] H. Abe, M. Esashi, and T. Matsuo, “ISFET's using inorganic gate thin films. IEEE Transactions on Electron Devices,” vol. 26, pp. 1939-1944, 1979.
[51] J. Kwon, B-H. Lee, S-Y. Kim, J-Y. Park, H. Bae, Y-K. Choi, et al. “Nanoscale FET-based transduction toward sensitive extended-gate biosensors,” ACS sensors, vol. 4, pp. 1724-1729, 2019.
[52] R. Chaudhary, A. Sharma, S. Sinha, J. Yadav, R. Sharma, R. Mukhiya, et al. “Fabrication and characterisation of Al gate n‐metal–oxide–semiconductor field‐effect transistor, on‐chip fabricated with silicon nitride ion‐sensitive field‐effect transistor,” IET Computers & Digital Techniques, vol. 10, pp. 268-272, 2016.
[53] P. Firek, M. Wáskiewicz, B. Stonio, and J. Szmidt, “Properties of AlN thin films deposited by means of magnetron sputtering for ISFET applications,” Materials Science-Poland, vol. 33, pp. 669-676, 2015.
[54] S. Nakata, T. Arie, S. Akita, K. Takei, “Wearable, flexible, and multifunctional healthcare device with an ISFET chemical sensor for simultaneous sweat pH and skin temperature monitoring,” ACS sensors, vol. 2, pp. 443-448, 2017.
[55] K. Singh, J-L. Her, B-S. Lou, S-T. Pang, and T-M. Pan, “An extended-gate FET-based pH sensor with an InZn x O y membrane fabricated on a flexible polyimide substrate at room temperature,” IEEE Electron Device Letters, vol. 40, pp. 804-807, 2019.
[56] Q. Zhang, HS. Majumdar, M. Kaisti, A. Prabhu, A. Ivaska, R. Österbacka, et al. “Surface functionalization of ion-sensitive floating-gate field-effect transistors with organic electronics,” IEEE Transactions on Electron Devices, vol. 62, pp. 1291-1298, 2015.
[57] L. Chen, H. Yu, J. Zhong, J. Wu, and W. Su, “Graphene based hybrid/composite for electron field emission: a review,” Journal of Alloys and Compounds, vol. 749, pp. 60-84, 2018.
[58] B. Radisavljevic, A. Radenovic, J. Brivio, V. Giacometti, and A. Kis, “Single-layer MoS2 transistors,” Nature nanotechnology, vol. 6, pp. 147-150, 2011.
[59] J. Shan, J. Li, X. Chu, M. Xu, F. Jin, X. Wang, et al. “High sensitivity glucose detection at extremely low concentrations using a MoS 2-based field-effect transistor,” RSC advances, vol. 8, pp. 7942-7948, 2018.
[60] C. Zheng, X. Jin, Y. Li, J. Mei, Y. Sun, M. Xiao, et al. “Sensitive molybdenum disulfide based field effect transistor sensor for real-time monitoring of hydrogen peroxide,” Scientific Reports, vol.9, pp. 759, 2019.
[61] G. Zhou, J. Chang, H. Pu, K. Shi, S. Mao, X. Sui, et al. “Ultrasensitive mercury ion detection using DNA-functionalized molybdenum disulfide nanosheet/gold nanoparticle hybrid field-effect transistor device,” Acs Sensors, vol.1, pp. 295-302, 2016.
[62] J. Chang, H. Pu, SA. Wells, K. Shi, X. Guo, G. Zhou, et al. “Semi-quantitative design of black phosphorous field-effect transistor sensors for heavy metal ion detection in aqueous media,” Molecular Systems Design & Engineering, vol.4, pp. 491-502, 2019.
[63] Y. Chen, R. Ren, H. Pu, J. Chang, S. Mao, and J. Chen, “Field-effect transistor biosensors with two-dimensional black phosphorus nanosheets,” Biosensors and Bioelectronics, vol. 89, pp. 505-510, 2017.
[64] S. Kim, G. Lee, and J. Kim, “Chemical doping effects of gas molecules on black phosphorus field-effect transistors,” ECS Journal of Solid State Science and Technology, vol. 7, pp. Q3065, 2018.
[65] X. Li, Y. Lu, and Q. Liu, “Electrochemical and optical biosensors based on multifunctional MXene nanoplatforms: Progress and prospects, Talanta, vol. 235, pp. 122726, 2021.
[66] B. Xu, M. Zhu, W. Zhang, X. Zhen, Z. Pei, Q. Xue, et al. “Ultrathin MXene‐micropattern‐based field‐effect transistor for probing neural activity,” Advanced Materials, vol.28, pp. 3333-3339, 2016.
[67] S. Hao, C. Liu, X. Chen, B. Zong, X. Wei, Q. Li, et al. “Ti3C2Tx MXene sensor for rapid Hg2+ analysis in high salinity environment,” Journal of Hazardous Materials, vol. 418, pp.126301, 2021.
[68] C. Liu, S. Hao, X. Chen, B. Zong, and S. Mao, “High Anti-Interference Ti3C2T x MXene Field-Effect-Transistor-Based Alkali Indicator,” ACS applied materials & interfaces, vol. 12, pp. 32970 (1-8), 2020.
[69] Y. Li, Z. Peng, NJ. Holl, MR. Hassan, JM. Pappas, C. Wei, et al. “MXene–graphene field-effect transistor sensing of influenza virus and SARS-CoV-2, ACS omega, vol.6, pp. 6643-6653, 2021.
[70] S. Kim, T. Rim, K. Kim, U. Lee, E. Baek, H. Lee, et al. “Silicon nanowire ion sensitive field effect transistor with integrated Ag/AgCl electrode: pH sensing and noise characteristics,” Analyst, vol. 136, pp. 5012-5016, 2011.
[71] Z. Dong and UC. Wejinya, “Chalamalasetty SNS. Development of CNT-ISFET based pH sensing system using atomic force microscopy,” Sensors and Actuators A: Physical, vol. 173, pp. 293-301, 2012.
[72] S. Ma, X. Li, Y-K. Lee, and A. Zhang, “Direct label-free protein detection in high ionic strength solution and human plasma using dual-gate nanoribbon-based ion-sensitive field-effect transistor biosensor,” Biosensors and Bioelectronics, vol. 117, pp. 276-282, 2018.
[73] C-T. Lee and Y-S. Chiu, “Photoelectrochemical passivated ZnO-based nanorod structured glucose biosensors using gate-recessed AlGaN/GaN ion-sensitive field-effect-transistors,” Sensors and Actuators B: Chemical, vol. 210, pp. 756-761, 2015.
[74] S-J. Young, L-T. Lai, and W-L. Tang, “Improving the performance of pH sensors with one-dimensional ZnO nanostructures,” IEEE Sensors Journal, vol. 19, pp. 10972(1-6), 2019.
[75] M. Hajmirzaheydarali, M. Akbari, A. Shahsafi, S. Soleimani-Amiri, M. Sadeghipari, S. Mohajerzadeh, et al. “Ultrahigh sensitivity DNA detection using nanorods incorporated ISFETs,” IEEE Electron Device Letters, vol. 37, pp. 663-666, 2016.
[76] N. Abd-Alghafour, NM. Ahmed, Z. Hassan, and MA. Almessiere, “Hydrothermal synthesis and structural properties of V2O5 Nanoflowers at low temperatures,” Journal of Physics: Conference Series, Vol. 1083, pp. 012036, 2018.
[77] T.Z.M.M.M. Min, S. Phanabamrung, W. Chaisriratanakul, A. Pankiew, A. Srisuwan, K. Chauyrod, et al. “Biosensors Based on Ion-Sensitive Field-Effect Transistors for HLA and MICA Antibody Detection in Kidney Transplantation,” Molecules, vol.27, pp. 6697, 2022.
[78] DH. Kim, HS. Cho, J.H. Kim, DA. Jo, HG. Oh, BK. Jang, et al. “The integration of reference electrode for ISFET ion sensors using fluorothiophenol-treated RGO,” Biosensors, vol.13, pp. 89, 2023.
[79] T-H. Hyun and W-J. Cho, “High-Performance Potassium-Selective Biosensor Platform Based on Resistive Coupling of a-IGZO Coplanar-Gate Thin-Film Transistor,” International Journal of Molecular Sciences, vol. 24, pp. 6164, 2023.
[80] MM. Hasnan, G. Lim, N. Nayan, C. Soon, AA. Halim, M. Ahmad, et al. “The investigation of chlorpyrifos (Cpy) detection of PEDOT: PSS-MXene (Ti2CT X)-BSA-GO composite using P-ISFET reduction method,” Polymer Bulletin, vol. 80, pp. 1243-1264, 2023.
[81] AA. Noroozi and Y. Abdi, “A graphene/Si Schottky diode for the highly sensitive detection of protein,” RSC advances, vol.9, pp. 19613-19619, 2019.
[82] A. Ghadakchi and Y. Abdi, “Reduced graphene oxide/silicon nanowire heterojunction for high sensitivity and broadband photodetector,” IEEE Sensors Letters, vol. 3, pp. 1-4, 2019.
[83] A. Şenocak, E. Korkmaz, A. Khataee, and E. Demirbas, “A facile and synergetic strategy for electrochemical sensing of rutin antioxidant by Ce–Cr doped magnetite@ rGO,” Materials Chemistry and Physics, vol. 275, pp. 125298, 2022.
[84] PR. de Almeida, AM. Murad, LP. Silva, EL. Rech, and ES. Alves, “Development of a Graphene-Based Biosensor for Detecting Recombinant Cyanovirin-N,” Biosensors, vol. 10, pp. 206, 2020.
[85] MD. Prakash, BG. Nelam, S. Ahmadsaidulu, A. Navaneetha, and AK. Panigrahy, “Performance analysis of ion-sensitive field effect transistor with various oxide materials for biomedical applications,” Silicon, vol.1, pp. 1-11, 2021.
[86] N. Moser, TS. Lande, C. Toumazou, and P. Georgiou, “ISFETs in CMOS and emergent trends in instrumentation: A review,” IEEE Sensors Journal, vol. 16, pp. 6496-6514, 2016.
[87] B. Nemeth, MS. Piechocinski, and DR. Cumming, “High-resolution real-time ion-camera system using a CMOS-based chemical sensor array for proton imaging,” Sensors and Actuators B: Chemical, vol. 171, pp. 747-752, 2012.
[88] V. Pachauri and S. Ingebrandt, “Biologically sensitive field-effect transistors: from ISFETs to NanoFETs,” Essays in biochemistry, vol. 60, pp. 81-90, 2016.
[89] J. Broomfield, M. Kalofonou, T. Pataillot-Meakin, SM. Powell, RC. Fernandes, N. Moser, et al. “Detection of YAP1 and AR-V7 mRNA for Prostate Cancer prognosis using an ISFET Lab-On-Chip platform,” ACS sensors, vol. 7, pp. 3389-3398, 2022.
[90] MK. Bind and K. Nigam, “Sensitivity analysis of junction free electrostatically doped tunnel-FET based biosensor,” Silicon, vol. 1, pp. 1-13, 2022.
[91] A. Nukazuka, S. Asai, K. Hayakawa, K. Nakagawa, M. Kanazashi, H. Kakizoe, et al. “Electrical biosensing system utilizing ion-producing enzymes conjugated with aptamers for the sensing of severe acute respiratory syndrome coronavirus 2,” Sensing and Bio-Sensing Research, vol. , pp. 100549, 2023.
[92] V. Dhandapani and B. Raj, “Design and Performance Assessment of Graded Channel Gate-All-Around Silicon Nanowire FET for Biosensing Applications, Silicon, vol. , pp. 1-8, 2023.
[93] Y. Kim and W-J. Cho, “Self-sensitivity amplifiable dual-gate ion-sensitive field-effect transistor based on high-k engineered dielectric layer,” Japanese Journal of Applied Physics. 2023.
[94] V. Prathap and AH. Titus, “ISFET Pixel Array with selectable sensitivity and bulk-based offset-drift nullification capability for reduction of non-ideality effects,” IEEE Sensors Journal. 2023.
[95] A. la Grasta, M. De Carlo, A. Di Nisio, F. Dell’Olio and VM. Passaro, “Potentiometric Chloride Ion Biosensor for Cystic Fibrosis Diagnosis and Management: Modeling and Design,” Sensors, vol. 23, pp. 2491, 2023.
[96] O. Synhaivska, Y. Mermoud, M. Baghernejad, I. Alshanski, M. Hurevich, S. Yitzchaik, et al. “Detection of Cu2+ ions with GGH peptide realized with Si-nanoribbon ISFET,” Sensors, vol. 19, pp. 4022, 2019.
[97] I. Fakih, A. Centeno, A. Zurutuza, B. Ghaddab, M. Siaj, and T. Szkopek, “High resolution potassium sensing with large-area graphene field-effect transistors,” Sensors and Actuators B: Chemical, vol. 291, pp. 89-95, 2019.
[98] A. la Grasta, M. De Carlo, F. Dell’Olio, and VM. Passaro, “Modelling and Design of an ISFET-Based NaCl Sensor for Cystic Fibrosis Diagnosis and Management,” Proceedings of SIE 2022: 53rd Annual Meeting of the Italian Electronics Society: Springer, vol. , pp. 117-121, 2023.
[99] RA. Rani and O. Sidek, “ISFET pH sensor characterization: towards biosensor microchip application,” IEEE Region 10 Conference TENCON, Vol. 500, pp. 660-663, 2004.
[100] AP. Soldatkin, VN. Arkhypova, SV. Dzyadevych, V. Anna, J-M. Gravoueille, N. Jaffrezic-Renault, et al. “Analysis of the potato glycoalkaloids by using of enzyme biosensor based on pH-ISFETs,” Talanta, vol.66, pp. 28-33, 2005.
[101] D. Zhu, Y. Sun, and Z. Shi, “Research of CMOS biosensor IC for extracellular electrophysiological signal recording and pH value measuring,” 2008 9th International Conference on Solid-State and Integrated-Circuit Technology: IEEE, vol. , pp. 2557-60, 2008.
[102] T-E. Bae, H-J. Jang, S-W. Lee, and W-J. Cho, “Enhanced sensing properties by dual-gate ion-sensitive field-effect transistor using the solution-processed Al2O3 sensing membranes,” Japanese Journal of Applied Physics, vol. 52, pp. 06GK3, 2013.
[103] HJ. Chen and C-Y. Chen, “Ion-sensitive field-effect transistors with periodic-groove channels fabricated using nanoimprint lithography,” IEEE electron device letters, vol.34, pp. 541-543, 2013.
[104] JC. Dutta, HR. Thakur, and G. Keshwani, “High-Performance Dual-Gate Carbon Nanotube Ion-Sensitive Field Effect Transistor With High-$\kappa $ Top Gate and Low-$\kappa $ Bottom Gate Dielectrics,” IEEE Sensors Journal, vol. 19, pp. 5692-5699, 2019.
[105] Y. Wang, M. Yang, and C. Wu, “Design and implementation of a pH sensor for micro solution based on nanostructured ion-sensitive field-effect transistor,” Sensors, vol. 20, pp. 6921, 2020.
[106] A. Zain, AM. Dinar, F. Salehuddin, H. Hazura, A. Hanim, S. Idris, et al. “Beyond Nernst Sensitivity of Ion Sensitive Field Effect Transistor based on Ultra-Thin Body Box FDSOI,” Journal of Physics: Conference Series, Vol. 1502, pp. 012048, 2020.
[107] Jeon J-H, Cho W-J. “High-performance extended-gate ion-sensitive field-effect transistors with multi-gate structure for transparent, flexible, and wearable biosensors,” Science and Technology of Advanced Materials. Vol. 21, pp. 371-378, 2020.
[108] Cho S-K, Cho W-J. “Ultra-high sensitivity pH-sensors using silicon nanowire channel dual-gate field-effect transistors fabricated by electrospun polyvinylpyrrolidone nanofibers pattern template transfer,” Sensors and Actuators B: Chemical. Vol. 326, pp.128835, 2021.
[109] BS. Emmanuel, “Analysis of output characteristics of ion sensitive field effect transistor based biosensor for measurement of pH in biochemical solutions,” Global Journal of Engineering and Technology Advances. Vol. 11, pp. 087-095, 2022.
[110] Vu C-A, Chen W-Y. “Field-effect transistor biosensors for biomedical applications: recent advances and future prospects,” Sensors. Vol. 19, pp. 4214, 2019.
[111] B. Veigas, E. Fortunato, and PV. Baptista. “Field effect sensors for nucleic acid detection: recent advances and future perspectives,” Sensors. Vol. 15, pp.10380-10398, 2015.
[112] Lee C-S, Kim SK, and Kim M. “Ion-sensitive field-effect transistor for biological sensing,” Sensors. Vol. 9, pp. 7111-7131, 2009.
[113] M. Mahdavi, A. Samaeian, M. Hajmirzaheydarali, M. Shahmohammadi, S. Mohajerzadeh, and M. Malboobi, “Label-free detection of DNA hybridization using a porous poly-Si ion-sensitive field effect transistor,” RSC advances. Vol. 4, pp. 36854-36863, 2014.
[114] Xu G, Abbott J, and Ham D. “Optimization of CMOS-ISFET-based biomolecular sensing: analysis and demonstration in DNA detection,” IEEE Transactions on Electron Devices. Vol. 63, pp. 3249-3256, 2016.
[115] Ma S, Lee Y-K, Zhang A, and Li X. “Label-free detection of Cordyceps sinensis using dual-gate nanoribbon-based ion-sensitive field-effect transistor biosensor,” Sensors and Actuators B: Chemical. Vol. 264, pp. 344-352, 2018.
[116] Chang C-F, and Lu MS-C, “CMOS ion sensitive field effect transistors for highly sensitive detection of DNA hybridization,” IEEE Sensors Journal. Vol. 20, pp. 8930-8937, 2020.
[117] Xu Y, Tavakkoli H, Xu J, and Lee Y-K. A. “Low-drift Extended-Gate Field Effect Transistor (EGFET) with Differential Amplifier for Cordyceps Sinensis DNA Detection Optimized by g m/I D Theory,” 2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS): IEEE, pp. 398-401, 2020.
[118] Lee C, Chen Y-W, and Lu MS-C. “CMOS biosensors for the detection of DNA hybridization in high ionic-strength solutions,” IEEE Sensors Journal. Vol. 21, pp. 4135-4142, 2020.
[119] A. Ganguli, V. Faramarzi, A. Mostafa, MT. Hwang, S. You, and R. Bashir. “High sensitivity graphene field effect transistor‐based detection of DNA amplification,” Advanced Functional Materials. Vol. 30, pp. 2001031, 2020.
[120] P. Sun, Y. Cong, M. Xu, H. Si, D. Zhao, and D. Wu, “An ISFET microarray sensor system for detecting the DNA base pairing,” Micromachines. Vol. 12, pp. 731, 2021.
[121] X. You and JJ. Pak, “Graphene-based field effect transistor enzymatic glucose biosensor using silk protein for enzyme immobilization and device substrate,” Sensors and Actuators B: Chemical. Vol. 202, pp. 1357-1365, 2014.
[122] L. Sarcina, E. Macchia, A. Tricase, C. Scandurra, A. Imbriano, F. Torricelli, et al. “Enzyme based field effect transistor: State‐of‐the‐art and future perspectives,” Electrochemical Science Advances. pp. e2100216, 2022 .
[123] Bhatt VD, Joshi S, Becherer M, and Lugli P. “Flexible, low-cost sensor based on electrolyte gated carbon nanotube field effect transistor for organo-phosphate detection,” Sensors. Vol. 17, pp. 1147, 2017.
[124] Wang R, Wang Y, Qu H, and Zheng L. “An Acetylcholinesterase-Functionalized Biosensor for Sensitive Detection of Organophosphorus Pesticides Based on Solution-Gated Graphene Transistors,” ACS Agricultural Science & Technology. Vol. 1, pp. 372-378, 2021.
[125] Arkhypova V, Soldatkin O, Mozhylevska L, Konvalyuk I, Kunakh V, and Dzyadevych S. “Enzyme biosensor based on pH‐sensitive field‐effect transistors for assessment of total indole alkaloids content in tissue culture of Rauwolfia serpentine,” Electrochemical Science Advances. Vol. 2, pp. e2100152, 2022.
[126] Fenoy GE, Marmisollé WA, Azzaroni O, and Knoll W. “Acetylcholine biosensor based on the electrochemical functionalization of graphene field-effect transistors,” Biosensors and Bioelectronics. Vol. 148, pp. 111796, 2020.
[127] Chae M-S, Yoo YK, Kim J, Kim TG, and Hwang KS. “Graphene-based enzyme-modified field-effect transistor biosensor for monitoring drug effects in Alzheimer’s disease treatment,” Sensors and Actuators B: Chemical. Vol. 272, pp. 448-458, 2018.
[128] Korpan YI, Raushel FM, Nazarenko EA, Soldatkin AP, Jaffrezic-Renault N, and Martelet C. “Sensitivity and specificity improvement of an ion sensitive field effect transistors-based biosensor for potato glycoalkaloids detection,” Journal of agricultural and food chemistry. Vol. 54, pp. 707-712, 2006.
[129] Kwak YH, Choi DS, Kim YN, Kim H, Yoon DH, Ahn S-S, et al. “Flexible glucose sensor using CVD-grown graphene-based field effect transistor,” Biosensors and Bioelectronics. Vol. 37, pp. 82-87, 2012.
[130] Wang B, Luo Y, Gao L, Liu B, and Duan G. “High-performance field-effect transistor glucose biosensors based on bimetallic Ni/Cu metal-organic frameworks,” Biosensors and Bioelectronics. Vol. 171, pp. 112736, 2021.
[131] Farahmandpour M, Haghshenas H, and Kordrostami Z. “Blood glucose sensing by back gated transistor strips sensitized by CuO hollow spheres and rGO,” Scientific Reports, Vol. 12, pp. 21872, 2022.
[132] Archana R, Sreeja B, Nagarajan K, Radha S, BalajiBhargav P, Balaji C, et al. “Development of highly sensitive Ag NPs decorated graphene FET sensor for detection of glucose concentration,” Journal of Inorganic and Organometallic Polymers and Materials. Vol. 30, pp. 3818-3825, 2020.
[133] M. Farahmandpour, Z. Kordrostami, M. Rajabzadeh, and R. Khalifeh, “Flexible Bio-Electronic Hybrid Metal-Oxide Channel FET as a Glucose Sensor,” IEEE Transactions on NanoBioscience. 2023.
[134] K. Koike, T. Sasaki, K. Hiraki, K. Ike, Y. Hirofuji, and M. Yano. “Characteristics of an extended gate field-effect transistor for glucose sensing using an enzyme-containing silk fibroin membrane as the bio-chemical component,” Biosensors. Vol. 10, pp. 57, 2020.
[135] JW. Park, C. Lee, and J. Jang, “High-performance field-effect transistor-type glucose biosensor based on nanohybrids of carboxylated polypyrrole nanotube wrapped graphene sheet transducer,” Sensors and Actuators B: Chemical. Vol. 208, pp. 532-537, 2015.
[136] Das M, Chakraborty T, Lin CY, Lin R-M, and Kao CH. “Screen-printed Ga2O3 thin film derived from liquid metal employed in highly sensitive pH and non-enzymatic glucose recognition,” Materials Chemistry and Physics. Vol. 278, pp.125652, 2022.
[137] Forzani ES, Zhang H, Nagahara LA, Amlani I, Tsui R, and Tao N. “A conducting polymer nanojunction sensor for glucose detection,” Nano Letters. Vol. 4, pp. 1785-1788, 2004.
[138] H. Yoon, S. Ko, and J. Jang, “Field-effect-transistor sensor based on enzyme-functionalized polypyrrole nanotubes for glucose detection,” The Journal of Physical Chemistry B. vol. 112, pp. 9992-9997, 2008.
[139] Huang Y, Dong X, Shi Y, Li CM, Li L-J, and Chen P. “Nanoelectronic biosensors based on CVD grown graphene,” Nanoscale. Vol. 2, pp. 1485-1488, 2010.
[140] Wu Y-L, Hsu P-Y, and Lin J-J. “Polysilicon wire glucose sensor highly immune to interference,” Biosensors and Bioelectronics. Vol. 26, pp. 2281-2286, 2011.
[141] Luo X-L, Xu J-J, Zhao W, Chen H-Y. Glucose biosensor based on ENFET doped with SiO2 nanoparticles. Sensors and Actuators B: Chemical. Vol. 97, pp. 249-255, 2004.
[142] Tomari N, Sasamoto K, Sakai H, Tani T, Yamamoto Y, and Nishiya Y. “New enzymatic assays based on the combination of signal accumulation type of ion sensitive field effect transistor (SA-ISFET) with horseradish peroxidase,” Analytical biochemistry. Vol. 584, pp. 113353, 2019.
[143] MS. Andrianova, VP. Grudtsov, NV. Komarova, EV. Kuznetsov, and AE. Kuznetsov, “ISFET-based aptasensor for thrombin detection using horseradish peroxidase,” Procedia engineering. Vol. 174, pp. 1084-1092, 2017.
[144] AA. Shul'ga and TD. Gibson, “An alternative microbiosensor for hydrogen peroxide based on an enzyme field effect transistor with a fast response,” Analytica chimica acta. Vol. 296, pp. 163-170, 1994.
[145] V. Volotovsky and N. Kim, “Multienzyme inhibition biosensor for amygdalin measurement,” Electroanalysis: An International Journal Devoted to Fundamental and Practical Aspects of Electroanalysis. Vol. 10, pp. 512-514, 1998.
[146] V. Volotovsky and N. Kim. “Cyanide determination by an ISFET-based peroxidase biosensor,” Biosensors and Bioelectronics. Vol. 13, pp. 1029-1033, 1998.
[147] V. Volotovsky and N. Kim, “Determination of glucose, ascorbic and citric acids by two-ISFET multienzyme sensor,” Sensors and Actuators B: Chemical. Vol. 49, pp. 253-257, 1998.
[148] Starodub N, Dzantiev B, Starodub V, and Zherdev A. “Immunosensor for the determination of the herbicide simazine based on an ion-selective field-effect transistor,” Analytica Chimica Acta. Vol. 424, pp. 37-43, 2000.
[149] Z. Wang, H. Yu, and Z. Zhao, “Silk fibroin hydrogel encapsulated graphene filed-effect transistors as enzyme-based biosensors,” Microchemical Journal. Vol. 169, pp. 106585, 2021.
[150] MA. Barik, MK. Sarma, C. Sarkar, and JC. Dutta, “Highly sensitive potassium-doped polypyrrole/carbon nanotube-based enzyme field effect transistor (ENFET) for cholesterol detection,” Applied biochemistry and biotechnology. Vol. 174, pp. 1104-1114, 2014.
[151] H. Suzuki and Y. Matsugi, “Integrated microfluidic system for the simultaneous determination of ammonia, creatinine, and urea,” Sensors and Actuators B: Chemical. Vol. 108, pp. 700-707, 2005.
[152] M. Jurkiewicz, S. Alegret, J. Almirall, M. Garcia, E. Fabregas, “Development of a biparametric bioanalyser for creatinine and urea,” Validation of the determination of biochemical parameters associated with hemodialysis. Analyst. Vol. 123, pp. 1321-1327, 1998.
[153] Wesoły M, Cetó X, Del Valle M, Ciosek P, and Wróblewski W. “Quantitative analysis of active pharmaceutical ingredients (APIs) using a potentiometric electronic tongue in a SIA flow system,” Electroanalysis. Vol. 28, pp. 626-632, 2016.
[154] Ebrahimi S, Nataj ZE, Khodaverdian S, Khamsavi A, Abdi Y, and Khajeh K. “An ion-sensitive field-effect transistor biosensor based on SWCNT and aligned MWCNTs for detection of ABTS,” IEEE Sensors Journal. Vol. 20, pp. 14590-14597, 2020.
[155] Bi Y, Ye L, Mao Y, Wang L, Qu H, Liu J, et al. “Porous carbon supported nanoceria derived from one step in situ pyrolysis of Jerusalem artichoke stalk for functionalization of solution-gated graphene transistors for real-time detection of lactic acid from cancer cell metabolism,” Biosensors and Bioelectronics. Vol. 140, pp. 111271, 2019.
[156] Kotsakis SD, Miliotis G, Tzelepi E, Tzouvelekis LS, and Miriagou V. “Detection of carbapenemase producing enterobacteria using an ion sensitive field effect transistor sensor,” Scientific Reports. Vol. 11, pp. 1-14, 2021.
[157] G. Keshwani, JC. Dutta, “CNT based high-κ dielectric Ion Sensitive Field Effect Transistor Based Cholesterol Biosensor,” Current Trends in Biotechnology and Pharmacy. Vol. 15, pp. 182-188, 2021.
[158] P-Y. Kuo, Y-Y. Chen, W-H. Lai, and C-H. Chang, “An extended-gate field-effect transistor applied to resistive divider integrated with the readout circuit using 180nm CMOS process for uric acid detection,” IEEE Sensors Journal. Vol. 21, pp. 20229-20238, 2021.
[159] Liu N, Xiang X, Fu L, Cao Q, Huang R, Liu H, et al. “Regenerative field effect transistor biosensor for in vivo monitoring of dopamine in fish brains,” Biosensors and Bioelectronics. Vol. 188, pp. 113340, 2021.
[160] T-M. Pan and C-H. Lin, “High Performance NiOx Extended-Gate Field-Effect Transistor Biosensor for Detection of Uric Acid,” Journal of The Electrochemical Society. Vol. 168, pp. 017511, 2021.
[161] Jang H-J, Ahn J, Kim M-G, Shin Y-B, Jeun M, Cho W-J, et al. “Electrical signaling of enzyme-linked immunosorbent assays with an ion-sensitive field-effect transistor,” Biosensors and Bioelectronics. Vol. 64, pp. 318-323, 2015.
[162] O. Kutova, M. Dusheiko, NI. Klyui, and VA. Skryshevsky, “C-reactive protein detection based on ISFET structure with gate dielectric SiO2-CeO2,” Microelectronic Engineering. Vol. 215, pp. 110993, 2019.
[163] AE. Kuznetsov, NV. Komarova, EV. Kuznetsov, MS. Andrianova, VP. Grudtsov, EN. Rybachek, et al. “Integration of a field effect transistor-based aptasensor under a hydrophobic membrane for bioelectronic nose applications,” Biosensors and Bioelectronics. Vol. 129, pp. 29-35, 2019.
[164] R. Campos, J. Borme, and JR. Guerreiro, Jr G. Machado,MFt. Cerqueira, DY. Petrovykh, et al. “Attomolar label-free detection of DNA hybridization with electrolyte-gated graphene field-effect transistors,” ACS sensors. Vol. 4, pp. 286-293, 2019.
[1] A. Shinde, K. Illath, U. Kasiviswanathan, S. Nagabooshanam, P. Gupta, K. Dey, et al. “Recent Advances of Biosensor-Integrated Organ-on-a-Chip Technologies for Diagnostics and Therapeutics,” Analytical Chemistry, vol. 95, pp. 3121-3146, 2023.
[2] F. Ghasemi and A. Salimi, “Advances in 2D Based Field Effect Transistors as Biosensing Platforms: From Principle to Biomedical Applications,” Microchemical Journal, vol.187 pp.108432, 2023.
[3] K.S. Singh, P. Gupta, M. Rajoriya, N. Kumari, and A. Muskan, “Study of Tunnel Field Effect Transistors for Biosensing Applications: A Review,” International Conference on Computing, Communication, and Intelligent Systems (ICCCIS): IEEE, vol. 144, pp. 1-5, 2022.
[4] R. Jalili, A. Khataee, M-R. Rashidi, and A. Razmjou, “Detection of penicillin G residues in milk based on dual-emission carbon dots and molecularly imprinted polymers,” Food chemistry, vol. 314, pp. 126172, 2020.
[5] R. Shiwaku, H. Matsui, K. Nagamine, M. Uematsu, T. Mano, and Y .Maruyama, et al, “A printed organic amplification system for wearable potentiometric electrochemical sensors,” Scientific reports, vol. 8, pp. 3922 (1-8), 2018.
[6] M. Adampourezare, G. Dehghan, M. Hasanzadeh, and M-AH. Feizi, “Application of lateral flow and microfluidic bio-assay and biosensing towards identification of DNA-methylation and cancer detection: Recent progress and challenges in biomedicine,” Biomedicine & Pharmacotherapy, vol. 141, pp. 111845, 2021.
[7] H. Sohrabi, MR. Majidi, O. Arbabzadeh, P. Khaaki, S. Pourmohammad, A. Khataee, et al, “Recent advances in the highly sensitive determination of zearalenone residues in water and environmental resources with electrochemical biosensors,” Environmental Research, vol. 204, pp. 112082, 2022.
[8] T. Kuno, K. Niitsu, and K. Nakazato, “Amperometric electrochemical sensor array for on-chip simultaneous imaging,” Japanese Journal of Applied Physics, vol.53, pp. 04EL1, 2014.
[9] P. Bertoncello and R.J. Forster, “Nanostructured materials for electrochemiluminescence (ECL)-based detection methods: recent advances and future perspectives,” Biosensors and Bioelectronics, vol. 24, pp. 3191-3200, 2009.
[10] S. Rashtbari, G. Dehghan, S. Khataee, M. Amini, and A. Khataee, “Dual enzymes-mimic activity of nanolayered manganese-calcium oxide for fluorometric determination of metformin,” Chemosphere, vol. 291, pp. 133063, 2022.
[11] S. Rashtbari, G. Dehghan, and M. Amini, “An ultrasensitive label-free colorimetric biosensor for the detection of glucose based on glucose oxidase-like activity of nanolayered manganese-calcium oxide,” Analytica chimica acta, vol. 1110, pp. 98-108, 2020.
[12] B.A. Prabowo, A. Purwidyantri, and K-C. Liu, “Surface plasmon resonance optical sensor: A review on light source technology,” Biosensors, vol. 8, pp. 1-28, 2018.
[13] S. Cao, P. Sun, G. Xiao, Q. Tang, X. Sun, H. Zhao, Sh. Zhao, H. Lu, and Z. Yue, “ISFET‐based sensors for (bio) chemical applications: A review,” Electrochemical Science Advances, vol. 3, pp e2100207 (1-25), 2022.
[14] P. Bergveld, “Development of an ion-sensitive solid-state device for neurophysiological measurements,” IEEE Transactions on biomedical engineering, vol. 17, pp .70-71, 1970.
[15] Y. Su, W. Hsu, and CT. Lin, “Review field effect transistor biosensing: devices and clinical applications,” ECS J Solid State Sci Technol, vol.7, pp. Q3196 (1-7), 2018.
[16] W-S. Kao, Y-W. Hung, and C-H. Lin, “Solid-State Sensor Chip Produced with Single Laser Engraving for Urine Acidity and Total Dissolved Ion Detections,” ECS Journal of Solid State Science and Technology, vol. 9, pp. 115016, 2020.
[17] JT. Smith, SS. Shah, M. Goryll, JR. Stowell, and DR. Allee, “Flexible ISFET biosensor using IGZO metal oxide TFTs and an ITO sensing layer,” IEEE Sensors Journal, Vol. 14, pp. 937-938, 2013.
[18] T. Wadhera, D. Kakkar, G. Wadhwa, and B. Raj, “Recent advances and progress in development of the field effect transistor biosensor: A review,” Journal of Electronic Materials, vol. 48, pp. 7635-7646, 2019.
[19] AM. Dinar, AM. Zain, and F. Salehuddin, “Utilizing of CMOS ISFET sensors in DNA applications detection: A systematic review,” Jour Adv Res Dyn Control Syst. Vol. 10, pp. 569-583, 2018.
[20] L. Keeble, N. Moser, J. Rodriguez-Manzano, and P. Georgiou, “ISFET-based sensing and electric field actuation of DNA for on-chip detection: A review,” IEEE Sensors Journal, vol. 20, pp. 11044-11065, 2020.
[21] Y-C. Syu, W-E. Hsu, and C-T. Lin, “Field-effect transistor biosensing: Devices and clinical applications,” ECS Journal of Solid State Science and Technology, vol. 7, pp. Q3196, 2018.
[22] M. Wróblewska, “Miniaturized multiplexed bipotentiostat for field-effect transistor based biosensing: Katedra,” Biotechnologii Medycznej, 2023.
[23] JE. Lilienfeld and O. Heil, Transistor efek–medan. System.800:000.
[24] W. Shockley, “A unipolar field-effect transistor,” Proceedings of the IRE. Vol. 40, pp. 1365-1376, 1952.
[25] D. Kahng, “Silicon-silicon dioxide field induced surface devices," IRE Solid State Device Res Conf1960.
[26] Jr LC. Clark and C. Lyons, “Electrode systems for continuous monitoring in cardiovascular surgery,” Annals of the New York Academy of sciences, vol. 102, pp. 29-45, 1962.
[27] P. Bergveld, “Development, operation, and application of the ion-sensitive field-effect transistor as a tool for electrophysiology,” IEEE Transactions on Biomedical Engineering, vol. , pp. 342-351, 1972.
[28] K. Lundström, M. Shivaraman, and C. Svensson. “A hydrogen‐sensitive Pd‐gate MOS transistor,” Journal of Applied Physics, vol.46, pp. 3876-3881, 1975.
[29] S. Caras and J. Janata. “Field effect transistor sensitive to penicillin,” Analytical chemistry, vol. 52, pp. 1935-1937, 1980.
[30] L. Bousse, De. Rooij NF, and P. Bergveld, “Operation of chemically sensitive field-effect sensors as a function of the insulator-electrolyte interface,” IEEE Transactions on Electron Devices, vol. 30, pp. 1263-1270, 1983.
[31] J-i. Anzai, T. KUSANO, T. OSA, H. NAKAJIMA, T. MATSUO, “Urea sensor based on ion sensitive field effect transistor coated with cross-linked urease-albumin membrane,” Bunseki Kagaku, vol. 33, pp. E131-E136, 1984.
[32] Y. Miyahara, T. Moriizumi, and K. Ichimura, “Integrated enzyme FETs for simultaneous detections of urea and glucose,” Sensors and Actuators, vol. 7, pp. 1-10, 1985.
[33] BH. van der Schoot and P. Bergveld, “ISFET based enzyme sensors,” Biosensors, vol. 3, pp. 161-86, 1987.
[34] O. Boubriak, A. Soldatkin, N. Starodub, A. Sandrovsky, and A. El'skaya, “Determination of urea in blood serum by a urease biosensor based on an ion-sensitive field-effect transistor,” Sensors and Actuators B: Chemical, vol. 27, pp. 429-431, 1995.
[35] PB. Luppa, LJ. Sokoll, and DW. Chan, “Immunosensors—principles and applications to clinical chemistry,” Clinica chimica acta, vol. 314, pp. 1-26, 2001.
[36] DE. Yates, S. Levine, and TW. Healy, “Site-binding model of the electrical double layer at the oxide/water interface,” Journal of the Chemical Society, Faraday Transactions 1: Physical Chemistry in Condensed Phases, vol.70, pp. 1807-1818, 1974.
[37] AJ. Bard, LR Faulkner electrochemical methods, W iley, New York. 1980.
[38] A. Van den Berg, P. Bergveld, D. Reinhoudt, and E. Sudhölter, “Sensitivity control of ISFETs by chemical surface modification,” Sensors and Actuators, vol. 8, pp. 129-148, 1985.
[39] M. Yuqing, G. Jianguo, and C. Jianrong, “Ion sensitive field effect transducer-based biosensors,” Biotechnology advances, vol. 21, pp. 527-534, 2003.
[40] A. Simonis, T. Krings, H. Lüth, J. Wang, and MJ. Schöning, “A hybrid thin-film pH sensor with integrated thick-film reference,” Sensors, vol. 1, pp. 183-192, 2001.
[41] P. Bergveld, “Thirty years of ISFETOLOGY: What happened in the past 30 years and what may happen in the next 30 years,” Sensors and Actuators B: Chemical, vol. 88, pp. 1-20, 2003.
[42] R. Datar and G. Bacher, “Influence of Gate Material, Geometry, and Temperature on ISFET Performance in pH Sensing Applications,” Silicon, vol. 1, pp. 1-13, 2023.
[43] X. Ma, R. Peng, W. Mao, Y. Lin, and H. Yu, “Recent advances in ion‐sensitive field‐effect transistors for biosensing applications,” Electrochemical Science Advances, vol. , pp. e2100163, 2022.
[44] S. Honda, M. Shiomi, T. Yamaguchi, Y. Fujita, T. Arie, S. Akita, et al. “Detachable Flexible ISFET‐Based pH Sensor Array with a Flexible Connector,” Advanced Electronic Materials, vol. 6, pp. 2000583, 2020.
[45] J. Zhang, M. Rupakula, F. Bellando, E. Garcia Cordero, J. Longo, F. Wildhaber, et al. “Sweat biomarker sensor incorporating picowatt, three-dimensional extended metal gate ion sensitive field effect transistors,” Acs Sensors, vol. 4, pp. 2039-2047, 2019.
[46] H-J. Jang and W-J. Cho, “High performance silicon-on-insulator based ion-sensitive field-effect transistor using high-k stacked oxide sensing membrane,” Applied Physics Letters, vol. 99, pp. 043703, 2011.
[47] I-K. Lee, M. Jeun, H-J. Jang, W-J. Cho, and K. Lee, “A self-amplified transistor immunosensor under dual gate operation: highly sensitive detection of hepatitis B surface antigen,” Nanoscale, vol. 7, pp. 16789-16797, 2015.
[48] Y-H. Chang, Y-S. Lu, Y-L. Hong, S. Gwo, JA. Yeh, “Highly sensitive pH sensing using an indium nitride ion-sensitive field-effect transistor,” IEEE Sensors Journal, vol. 11, pp. 1157-1161, 2010.
[49] M. Myers, FLM. Khir, A. Podolska, GA. Umana-Membreno, B. Nener, M. Baker, et al. “Nitrate ion detection using AlGaN/GaN heterostructure-based devices without a reference electrode,” Sensors and Actuators B: Chemical, vol. 181, pp. 301-305, 2013.
[50] H. Abe, M. Esashi, and T. Matsuo, “ISFET's using inorganic gate thin films. IEEE Transactions on Electron Devices,” vol. 26, pp. 1939-1944, 1979.
[51] J. Kwon, B-H. Lee, S-Y. Kim, J-Y. Park, H. Bae, Y-K. Choi, et al. “Nanoscale FET-based transduction toward sensitive extended-gate biosensors,” ACS sensors, vol. 4, pp. 1724-1729, 2019.
[52] R. Chaudhary, A. Sharma, S. Sinha, J. Yadav, R. Sharma, R. Mukhiya, et al. “Fabrication and characterisation of Al gate n‐metal–oxide–semiconductor field‐effect transistor, on‐chip fabricated with silicon nitride ion‐sensitive field‐effect transistor,” IET Computers & Digital Techniques, vol. 10, pp. 268-272, 2016.
[53] P. Firek, M. Wáskiewicz, B. Stonio, and J. Szmidt, “Properties of AlN thin films deposited by means of magnetron sputtering for ISFET applications,” Materials Science-Poland, vol. 33, pp. 669-676, 2015.
[54] S. Nakata, T. Arie, S. Akita, K. Takei, “Wearable, flexible, and multifunctional healthcare device with an ISFET chemical sensor for simultaneous sweat pH and skin temperature monitoring,” ACS sensors, vol. 2, pp. 443-448, 2017.
[55] K. Singh, J-L. Her, B-S. Lou, S-T. Pang, and T-M. Pan, “An extended-gate FET-based pH sensor with an InZn x O y membrane fabricated on a flexible polyimide substrate at room temperature,” IEEE Electron Device Letters, vol. 40, pp. 804-807, 2019.
[56] Q. Zhang, HS. Majumdar, M. Kaisti, A. Prabhu, A. Ivaska, R. Österbacka, et al. “Surface functionalization of ion-sensitive floating-gate field-effect transistors with organic electronics,” IEEE Transactions on Electron Devices, vol. 62, pp. 1291-1298, 2015.
[57] L. Chen, H. Yu, J. Zhong, J. Wu, and W. Su, “Graphene based hybrid/composite for electron field emission: a review,” Journal of Alloys and Compounds, vol. 749, pp. 60-84, 2018.
[58] B. Radisavljevic, A. Radenovic, J. Brivio, V. Giacometti, and A. Kis, “Single-layer MoS2 transistors,” Nature nanotechnology, vol. 6, pp. 147-150, 2011.
[59] J. Shan, J. Li, X. Chu, M. Xu, F. Jin, X. Wang, et al. “High sensitivity glucose detection at extremely low concentrations using a MoS 2-based field-effect transistor,” RSC advances, vol. 8, pp. 7942-7948, 2018.
[60] C. Zheng, X. Jin, Y. Li, J. Mei, Y. Sun, M. Xiao, et al. “Sensitive molybdenum disulfide based field effect transistor sensor for real-time monitoring of hydrogen peroxide,” Scientific Reports, vol.9, pp. 759, 2019.
[61] G. Zhou, J. Chang, H. Pu, K. Shi, S. Mao, X. Sui, et al. “Ultrasensitive mercury ion detection using DNA-functionalized molybdenum disulfide nanosheet/gold nanoparticle hybrid field-effect transistor device,” Acs Sensors, vol.1, pp. 295-302, 2016.
[62] J. Chang, H. Pu, SA. Wells, K. Shi, X. Guo, G. Zhou, et al. “Semi-quantitative design of black phosphorous field-effect transistor sensors for heavy metal ion detection in aqueous media,” Molecular Systems Design & Engineering, vol.4, pp. 491-502, 2019.
[63] Y. Chen, R. Ren, H. Pu, J. Chang, S. Mao, and J. Chen, “Field-effect transistor biosensors with two-dimensional black phosphorus nanosheets,” Biosensors and Bioelectronics, vol. 89, pp. 505-510, 2017.
[64] S. Kim, G. Lee, and J. Kim, “Chemical doping effects of gas molecules on black phosphorus field-effect transistors,” ECS Journal of Solid State Science and Technology, vol. 7, pp. Q3065, 2018.
[65] X. Li, Y. Lu, and Q. Liu, “Electrochemical and optical biosensors based on multifunctional MXene nanoplatforms: Progress and prospects, Talanta, vol. 235, pp. 122726, 2021.
[66] B. Xu, M. Zhu, W. Zhang, X. Zhen, Z. Pei, Q. Xue, et al. “Ultrathin MXene‐micropattern‐based field‐effect transistor for probing neural activity,” Advanced Materials, vol.28, pp. 3333-3339, 2016.
[67] S. Hao, C. Liu, X. Chen, B. Zong, X. Wei, Q. Li, et al. “Ti3C2Tx MXene sensor for rapid Hg2+ analysis in high salinity environment,” Journal of Hazardous Materials, vol. 418, pp.126301, 2021.
[68] C. Liu, S. Hao, X. Chen, B. Zong, and S. Mao, “High Anti-Interference Ti3C2T x MXene Field-Effect-Transistor-Based Alkali Indicator,” ACS applied materials & interfaces, vol. 12, pp. 32970 (1-8), 2020.
[69] Y. Li, Z. Peng, NJ. Holl, MR. Hassan, JM. Pappas, C. Wei, et al. “MXene–graphene field-effect transistor sensing of influenza virus and SARS-CoV-2, ACS omega, vol.6, pp. 6643-6653, 2021.
[70] S. Kim, T. Rim, K. Kim, U. Lee, E. Baek, H. Lee, et al. “Silicon nanowire ion sensitive field effect transistor with integrated Ag/AgCl electrode: pH sensing and noise characteristics,” Analyst, vol. 136, pp. 5012-5016, 2011.
[71] Z. Dong and UC. Wejinya, “Chalamalasetty SNS. Development of CNT-ISFET based pH sensing system using atomic force microscopy,” Sensors and Actuators A: Physical, vol. 173, pp. 293-301, 2012.
[72] S. Ma, X. Li, Y-K. Lee, and A. Zhang, “Direct label-free protein detection in high ionic strength solution and human plasma using dual-gate nanoribbon-based ion-sensitive field-effect transistor biosensor,” Biosensors and Bioelectronics, vol. 117, pp. 276-282, 2018.
[73] C-T. Lee and Y-S. Chiu, “Photoelectrochemical passivated ZnO-based nanorod structured glucose biosensors using gate-recessed AlGaN/GaN ion-sensitive field-effect-transistors,” Sensors and Actuators B: Chemical, vol. 210, pp. 756-761, 2015.
[74] S-J. Young, L-T. Lai, and W-L. Tang, “Improving the performance of pH sensors with one-dimensional ZnO nanostructures,” IEEE Sensors Journal, vol. 19, pp. 10972(1-6), 2019.
[75] M. Hajmirzaheydarali, M. Akbari, A. Shahsafi, S. Soleimani-Amiri, M. Sadeghipari, S. Mohajerzadeh, et al. “Ultrahigh sensitivity DNA detection using nanorods incorporated ISFETs,” IEEE Electron Device Letters, vol. 37, pp. 663-666, 2016.
[76] N. Abd-Alghafour, NM. Ahmed, Z. Hassan, and MA. Almessiere, “Hydrothermal synthesis and structural properties of V2O5 Nanoflowers at low temperatures,” Journal of Physics: Conference Series, Vol. 1083, pp. 012036, 2018.
[77] T.Z.M.M.M. Min, S. Phanabamrung, W. Chaisriratanakul, A. Pankiew, A. Srisuwan, K. Chauyrod, et al. “Biosensors Based on Ion-Sensitive Field-Effect Transistors for HLA and MICA Antibody Detection in Kidney Transplantation,” Molecules, vol.27, pp. 6697, 2022.
[78] DH. Kim, HS. Cho, J.H. Kim, DA. Jo, HG. Oh, BK. Jang, et al. “The integration of reference electrode for ISFET ion sensors using fluorothiophenol-treated RGO,” Biosensors, vol.13, pp. 89, 2023.
[79] T-H. Hyun and W-J. Cho, “High-Performance Potassium-Selective Biosensor Platform Based on Resistive Coupling of a-IGZO Coplanar-Gate Thin-Film Transistor,” International Journal of Molecular Sciences, vol. 24, pp. 6164, 2023.
[80] MM. Hasnan, G. Lim, N. Nayan, C. Soon, AA. Halim, M. Ahmad, et al. “The investigation of chlorpyrifos (Cpy) detection of PEDOT: PSS-MXene (Ti2CT X)-BSA-GO composite using P-ISFET reduction method,” Polymer Bulletin, vol. 80, pp. 1243-1264, 2023.
[81] AA. Noroozi and Y. Abdi, “A graphene/Si Schottky diode for the highly sensitive detection of protein,” RSC advances, vol.9, pp. 19613-19619, 2019.
[82] A. Ghadakchi and Y. Abdi, “Reduced graphene oxide/silicon nanowire heterojunction for high sensitivity and broadband photodetector,” IEEE Sensors Letters, vol. 3, pp. 1-4, 2019.
[83] A. Şenocak, E. Korkmaz, A. Khataee, and E. Demirbas, “A facile and synergetic strategy for electrochemical sensing of rutin antioxidant by Ce–Cr doped magnetite@ rGO,” Materials Chemistry and Physics, vol. 275, pp. 125298, 2022.
[84] PR. de Almeida, AM. Murad, LP. Silva, EL. Rech, and ES. Alves, “Development of a Graphene-Based Biosensor for Detecting Recombinant Cyanovirin-N,” Biosensors, vol. 10, pp. 206, 2020.
[85] MD. Prakash, BG. Nelam, S. Ahmadsaidulu, A. Navaneetha, and AK. Panigrahy, “Performance analysis of ion-sensitive field effect transistor with various oxide materials for biomedical applications,” Silicon, vol.1, pp. 1-11, 2021.
[86] N. Moser, TS. Lande, C. Toumazou, and P. Georgiou, “ISFETs in CMOS and emergent trends in instrumentation: A review,” IEEE Sensors Journal, vol. 16, pp. 6496-6514, 2016.
[87] B. Nemeth, MS. Piechocinski, and DR. Cumming, “High-resolution real-time ion-camera system using a CMOS-based chemical sensor array for proton imaging,” Sensors and Actuators B: Chemical, vol. 171, pp. 747-752, 2012.
[88] V. Pachauri and S. Ingebrandt, “Biologically sensitive field-effect transistors: from ISFETs to NanoFETs,” Essays in biochemistry, vol. 60, pp. 81-90, 2016.
[89] J. Broomfield, M. Kalofonou, T. Pataillot-Meakin, SM. Powell, RC. Fernandes, N. Moser, et al. “Detection of YAP1 and AR-V7 mRNA for Prostate Cancer prognosis using an ISFET Lab-On-Chip platform,” ACS sensors, vol. 7, pp. 3389-3398, 2022.
[90] MK. Bind and K. Nigam, “Sensitivity analysis of junction free electrostatically doped tunnel-FET based biosensor,” Silicon, vol. 1, pp. 1-13, 2022.
[91] A. Nukazuka, S. Asai, K. Hayakawa, K. Nakagawa, M. Kanazashi, H. Kakizoe, et al. “Electrical biosensing system utilizing ion-producing enzymes conjugated with aptamers for the sensing of severe acute respiratory syndrome coronavirus 2,” Sensing and Bio-Sensing Research, vol. , pp. 100549, 2023.
[92] V. Dhandapani and B. Raj, “Design and Performance Assessment of Graded Channel Gate-All-Around Silicon Nanowire FET for Biosensing Applications, Silicon, vol. , pp. 1-8, 2023.
[93] Y. Kim and W-J. Cho, “Self-sensitivity amplifiable dual-gate ion-sensitive field-effect transistor based on high-k engineered dielectric layer,” Japanese Journal of Applied Physics. 2023.
[94] V. Prathap and AH. Titus, “ISFET Pixel Array with selectable sensitivity and bulk-based offset-drift nullification capability for reduction of non-ideality effects,” IEEE Sensors Journal. 2023.
[95] A. la Grasta, M. De Carlo, A. Di Nisio, F. Dell’Olio and VM. Passaro, “Potentiometric Chloride Ion Biosensor for Cystic Fibrosis Diagnosis and Management: Modeling and Design,” Sensors, vol. 23, pp. 2491, 2023.
[96] O. Synhaivska, Y. Mermoud, M. Baghernejad, I. Alshanski, M. Hurevich, S. Yitzchaik, et al. “Detection of Cu2+ ions with GGH peptide realized with Si-nanoribbon ISFET,” Sensors, vol. 19, pp. 4022, 2019.
[97] I. Fakih, A. Centeno, A. Zurutuza, B. Ghaddab, M. Siaj, and T. Szkopek, “High resolution potassium sensing with large-area graphene field-effect transistors,” Sensors and Actuators B: Chemical, vol. 291, pp. 89-95, 2019.
[98] A. la Grasta, M. De Carlo, F. Dell’Olio, and VM. Passaro, “Modelling and Design of an ISFET-Based NaCl Sensor for Cystic Fibrosis Diagnosis and Management,” Proceedings of SIE 2022: 53rd Annual Meeting of the Italian Electronics Society: Springer, vol. , pp. 117-121, 2023.
[99] RA. Rani and O. Sidek, “ISFET pH sensor characterization: towards biosensor microchip application,” IEEE Region 10 Conference TENCON, Vol. 500, pp. 660-663, 2004.
[100] AP. Soldatkin, VN. Arkhypova, SV. Dzyadevych, V. Anna, J-M. Gravoueille, N. Jaffrezic-Renault, et al. “Analysis of the potato glycoalkaloids by using of enzyme biosensor based on pH-ISFETs,” Talanta, vol.66, pp. 28-33, 2005.
[101] D. Zhu, Y. Sun, and Z. Shi, “Research of CMOS biosensor IC for extracellular electrophysiological signal recording and pH value measuring,” 2008 9th International Conference on Solid-State and Integrated-Circuit Technology: IEEE, vol. , pp. 2557-60, 2008.
[102] T-E. Bae, H-J. Jang, S-W. Lee, and W-J. Cho, “Enhanced sensing properties by dual-gate ion-sensitive field-effect transistor using the solution-processed Al2O3 sensing membranes,” Japanese Journal of Applied Physics, vol. 52, pp. 06GK3, 2013.
[103] HJ. Chen and C-Y. Chen, “Ion-sensitive field-effect transistors with periodic-groove channels fabricated using nanoimprint lithography,” IEEE electron device letters, vol.34, pp. 541-543, 2013.
[104] JC. Dutta, HR. Thakur, and G. Keshwani, “High-Performance Dual-Gate Carbon Nanotube Ion-Sensitive Field Effect Transistor With High-$\kappa $ Top Gate and Low-$\kappa $ Bottom Gate Dielectrics,” IEEE Sensors Journal, vol. 19, pp. 5692-5699, 2019.
[105] Y. Wang, M. Yang, and C. Wu, “Design and implementation of a pH sensor for micro solution based on nanostructured ion-sensitive field-effect transistor,” Sensors, vol. 20, pp. 6921, 2020.
[106] A. Zain, AM. Dinar, F. Salehuddin, H. Hazura, A. Hanim, S. Idris, et al. “Beyond Nernst Sensitivity of Ion Sensitive Field Effect Transistor based on Ultra-Thin Body Box FDSOI,” Journal of Physics: Conference Series, Vol. 1502, pp. 012048, 2020.
[107] Jeon J-H, Cho W-J. “High-performance extended-gate ion-sensitive field-effect transistors with multi-gate structure for transparent, flexible, and wearable biosensors,” Science and Technology of Advanced Materials. Vol. 21, pp. 371-378, 2020.
[108] Cho S-K, Cho W-J. “Ultra-high sensitivity pH-sensors using silicon nanowire channel dual-gate field-effect transistors fabricated by electrospun polyvinylpyrrolidone nanofibers pattern template transfer,” Sensors and Actuators B: Chemical. Vol. 326, pp.128835, 2021.
[109] BS. Emmanuel, “Analysis of output characteristics of ion sensitive field effect transistor based biosensor for measurement of pH in biochemical solutions,” Global Journal of Engineering and Technology Advances. Vol. 11, pp. 087-095, 2022.
[110] Vu C-A, Chen W-Y. “Field-effect transistor biosensors for biomedical applications: recent advances and future prospects,” Sensors. Vol. 19, pp. 4214, 2019.
[111] B. Veigas, E. Fortunato, and PV. Baptista. “Field effect sensors for nucleic acid detection: recent advances and future perspectives,” Sensors. Vol. 15, pp.10380-10398, 2015.
[112] Lee C-S, Kim SK, and Kim M. “Ion-sensitive field-effect transistor for biological sensing,” Sensors. Vol. 9, pp. 7111-7131, 2009.
[113] M. Mahdavi, A. Samaeian, M. Hajmirzaheydarali, M. Shahmohammadi, S. Mohajerzadeh, and M. Malboobi, “Label-free detection of DNA hybridization using a porous poly-Si ion-sensitive field effect transistor,” RSC advances. Vol. 4, pp. 36854-36863, 2014.
[114] Xu G, Abbott J, and Ham D. “Optimization of CMOS-ISFET-based biomolecular sensing: analysis and demonstration in DNA detection,” IEEE Transactions on Electron Devices. Vol. 63, pp. 3249-3256, 2016.
[115] Ma S, Lee Y-K, Zhang A, and Li X. “Label-free detection of Cordyceps sinensis using dual-gate nanoribbon-based ion-sensitive field-effect transistor biosensor,” Sensors and Actuators B: Chemical. Vol. 264, pp. 344-352, 2018.
[116] Chang C-F, and Lu MS-C, “CMOS ion sensitive field effect transistors for highly sensitive detection of DNA hybridization,” IEEE Sensors Journal. Vol. 20, pp. 8930-8937, 2020.
[117] Xu Y, Tavakkoli H, Xu J, and Lee Y-K. A. “Low-drift Extended-Gate Field Effect Transistor (EGFET) with Differential Amplifier for Cordyceps Sinensis DNA Detection Optimized by g m/I D Theory,” 2020 IEEE 15th International Conference on Nano/Micro Engineered and Molecular System (NEMS): IEEE, pp. 398-401, 2020.
[118] Lee C, Chen Y-W, and Lu MS-C. “CMOS biosensors for the detection of DNA hybridization in high ionic-strength solutions,” IEEE Sensors Journal. Vol. 21, pp. 4135-4142, 2020.
[119] A. Ganguli, V. Faramarzi, A. Mostafa, MT. Hwang, S. You, and R. Bashir. “High sensitivity graphene field effect transistor‐based detection of DNA amplification,” Advanced Functional Materials. Vol. 30, pp. 2001031, 2020.
[120] P. Sun, Y. Cong, M. Xu, H. Si, D. Zhao, and D. Wu, “An ISFET microarray sensor system for detecting the DNA base pairing,” Micromachines. Vol. 12, pp. 731, 2021.
[121] X. You and JJ. Pak, “Graphene-based field effect transistor enzymatic glucose biosensor using silk protein for enzyme immobilization and device substrate,” Sensors and Actuators B: Chemical. Vol. 202, pp. 1357-1365, 2014.
[122] L. Sarcina, E. Macchia, A. Tricase, C. Scandurra, A. Imbriano, F. Torricelli, et al. “Enzyme based field effect transistor: State‐of‐the‐art and future perspectives,” Electrochemical Science Advances. pp. e2100216, 2022 .
[123] Bhatt VD, Joshi S, Becherer M, and Lugli P. “Flexible, low-cost sensor based on electrolyte gated carbon nanotube field effect transistor for organo-phosphate detection,” Sensors. Vol. 17, pp. 1147, 2017.
[124] Wang R, Wang Y, Qu H, and Zheng L. “An Acetylcholinesterase-Functionalized Biosensor for Sensitive Detection of Organophosphorus Pesticides Based on Solution-Gated Graphene Transistors,” ACS Agricultural Science & Technology. Vol. 1, pp. 372-378, 2021.
[125] Arkhypova V, Soldatkin O, Mozhylevska L, Konvalyuk I, Kunakh V, and Dzyadevych S. “Enzyme biosensor based on pH‐sensitive field‐effect transistors for assessment of total indole alkaloids content in tissue culture of Rauwolfia serpentine,” Electrochemical Science Advances. Vol. 2, pp. e2100152, 2022.
[126] Fenoy GE, Marmisollé WA, Azzaroni O, and Knoll W. “Acetylcholine biosensor based on the electrochemical functionalization of graphene field-effect transistors,” Biosensors and Bioelectronics. Vol. 148, pp. 111796, 2020.
[127] Chae M-S, Yoo YK, Kim J, Kim TG, and Hwang KS. “Graphene-based enzyme-modified field-effect transistor biosensor for monitoring drug effects in Alzheimer’s disease treatment,” Sensors and Actuators B: Chemical. Vol. 272, pp. 448-458, 2018.
[128] Korpan YI, Raushel FM, Nazarenko EA, Soldatkin AP, Jaffrezic-Renault N, and Martelet C. “Sensitivity and specificity improvement of an ion sensitive field effect transistors-based biosensor for potato glycoalkaloids detection,” Journal of agricultural and food chemistry. Vol. 54, pp. 707-712, 2006.
[129] Kwak YH, Choi DS, Kim YN, Kim H, Yoon DH, Ahn S-S, et al. “Flexible glucose sensor using CVD-grown graphene-based field effect transistor,” Biosensors and Bioelectronics. Vol. 37, pp. 82-87, 2012.
[130] Wang B, Luo Y, Gao L, Liu B, and Duan G. “High-performance field-effect transistor glucose biosensors based on bimetallic Ni/Cu metal-organic frameworks,” Biosensors and Bioelectronics. Vol. 171, pp. 112736, 2021.
[131] Farahmandpour M, Haghshenas H, and Kordrostami Z. “Blood glucose sensing by back gated transistor strips sensitized by CuO hollow spheres and rGO,” Scientific Reports, Vol. 12, pp. 21872, 2022.
[132] Archana R, Sreeja B, Nagarajan K, Radha S, BalajiBhargav P, Balaji C, et al. “Development of highly sensitive Ag NPs decorated graphene FET sensor for detection of glucose concentration,” Journal of Inorganic and Organometallic Polymers and Materials. Vol. 30, pp. 3818-3825, 2020.
[133] M. Farahmandpour, Z. Kordrostami, M. Rajabzadeh, and R. Khalifeh, “Flexible Bio-Electronic Hybrid Metal-Oxide Channel FET as a Glucose Sensor,” IEEE Transactions on NanoBioscience. 2023.
[134] K. Koike, T. Sasaki, K. Hiraki, K. Ike, Y. Hirofuji, and M. Yano. “Characteristics of an extended gate field-effect transistor for glucose sensing using an enzyme-containing silk fibroin membrane as the bio-chemical component,” Biosensors. Vol. 10, pp. 57, 2020.
[135] JW. Park, C. Lee, and J. Jang, “High-performance field-effect transistor-type glucose biosensor based on nanohybrids of carboxylated polypyrrole nanotube wrapped graphene sheet transducer,” Sensors and Actuators B: Chemical. Vol. 208, pp. 532-537, 2015.
[136] Das M, Chakraborty T, Lin CY, Lin R-M, and Kao CH. “Screen-printed Ga2O3 thin film derived from liquid metal employed in highly sensitive pH and non-enzymatic glucose recognition,” Materials Chemistry and Physics. Vol. 278, pp.125652, 2022.
[137] Forzani ES, Zhang H, Nagahara LA, Amlani I, Tsui R, and Tao N. “A conducting polymer nanojunction sensor for glucose detection,” Nano Letters. Vol. 4, pp. 1785-1788, 2004.
[138] H. Yoon, S. Ko, and J. Jang, “Field-effect-transistor sensor based on enzyme-functionalized polypyrrole nanotubes for glucose detection,” The Journal of Physical Chemistry B. vol. 112, pp. 9992-9997, 2008.
[139] Huang Y, Dong X, Shi Y, Li CM, Li L-J, and Chen P. “Nanoelectronic biosensors based on CVD grown graphene,” Nanoscale. Vol. 2, pp. 1485-1488, 2010.
[140] Wu Y-L, Hsu P-Y, and Lin J-J. “Polysilicon wire glucose sensor highly immune to interference,” Biosensors and Bioelectronics. Vol. 26, pp. 2281-2286, 2011.
[141] Luo X-L, Xu J-J, Zhao W, Chen H-Y. Glucose biosensor based on ENFET doped with SiO2 nanoparticles. Sensors and Actuators B: Chemical. Vol. 97, pp. 249-255, 2004.
[142] Tomari N, Sasamoto K, Sakai H, Tani T, Yamamoto Y, and Nishiya Y. “New enzymatic assays based on the combination of signal accumulation type of ion sensitive field effect transistor (SA-ISFET) with horseradish peroxidase,” Analytical biochemistry. Vol. 584, pp. 113353, 2019.
[143] MS. Andrianova, VP. Grudtsov, NV. Komarova, EV. Kuznetsov, and AE. Kuznetsov, “ISFET-based aptasensor for thrombin detection using horseradish peroxidase,” Procedia engineering. Vol. 174, pp. 1084-1092, 2017.
[144] AA. Shul'ga and TD. Gibson, “An alternative microbiosensor for hydrogen peroxide based on an enzyme field effect transistor with a fast response,” Analytica chimica acta. Vol. 296, pp. 163-170, 1994.
[145] V. Volotovsky and N. Kim, “Multienzyme inhibition biosensor for amygdalin measurement,” Electroanalysis: An International Journal Devoted to Fundamental and Practical Aspects of Electroanalysis. Vol. 10, pp. 512-514, 1998.
[146] V. Volotovsky and N. Kim. “Cyanide determination by an ISFET-based peroxidase biosensor,” Biosensors and Bioelectronics. Vol. 13, pp. 1029-1033, 1998.
[147] V. Volotovsky and N. Kim, “Determination of glucose, ascorbic and citric acids by two-ISFET multienzyme sensor,” Sensors and Actuators B: Chemical. Vol. 49, pp. 253-257, 1998.
[148] Starodub N, Dzantiev B, Starodub V, and Zherdev A. “Immunosensor for the determination of the herbicide simazine based on an ion-selective field-effect transistor,” Analytica Chimica Acta. Vol. 424, pp. 37-43, 2000.
[149] Z. Wang, H. Yu, and Z. Zhao, “Silk fibroin hydrogel encapsulated graphene filed-effect transistors as enzyme-based biosensors,” Microchemical Journal. Vol. 169, pp. 106585, 2021.
[150] MA. Barik, MK. Sarma, C. Sarkar, and JC. Dutta, “Highly sensitive potassium-doped polypyrrole/carbon nanotube-based enzyme field effect transistor (ENFET) for cholesterol detection,” Applied biochemistry and biotechnology. Vol. 174, pp. 1104-1114, 2014.
[151] H. Suzuki and Y. Matsugi, “Integrated microfluidic system for the simultaneous determination of ammonia, creatinine, and urea,” Sensors and Actuators B: Chemical. Vol. 108, pp. 700-707, 2005.
[152] M. Jurkiewicz, S. Alegret, J. Almirall, M. Garcia, E. Fabregas, “Development of a biparametric bioanalyser for creatinine and urea,” Validation of the determination of biochemical parameters associated with hemodialysis. Analyst. Vol. 123, pp. 1321-1327, 1998.
[153] Wesoły M, Cetó X, Del Valle M, Ciosek P, and Wróblewski W. “Quantitative analysis of active pharmaceutical ingredients (APIs) using a potentiometric electronic tongue in a SIA flow system,” Electroanalysis. Vol. 28, pp. 626-632, 2016.
[154] Ebrahimi S, Nataj ZE, Khodaverdian S, Khamsavi A, Abdi Y, and Khajeh K. “An ion-sensitive field-effect transistor biosensor based on SWCNT and aligned MWCNTs for detection of ABTS,” IEEE Sensors Journal. Vol. 20, pp. 14590-14597, 2020.
[155] Bi Y, Ye L, Mao Y, Wang L, Qu H, Liu J, et al. “Porous carbon supported nanoceria derived from one step in situ pyrolysis of Jerusalem artichoke stalk for functionalization of solution-gated graphene transistors for real-time detection of lactic acid from cancer cell metabolism,” Biosensors and Bioelectronics. Vol. 140, pp. 111271, 2019.
[156] Kotsakis SD, Miliotis G, Tzelepi E, Tzouvelekis LS, and Miriagou V. “Detection of carbapenemase producing enterobacteria using an ion sensitive field effect transistor sensor,” Scientific Reports. Vol. 11, pp. 1-14, 2021.
[157] G. Keshwani, JC. Dutta, “CNT based high-κ dielectric Ion Sensitive Field Effect Transistor Based Cholesterol Biosensor,” Current Trends in Biotechnology and Pharmacy. Vol. 15, pp. 182-188, 2021.
[158] P-Y. Kuo, Y-Y. Chen, W-H. Lai, and C-H. Chang, “An extended-gate field-effect transistor applied to resistive divider integrated with the readout circuit using 180nm CMOS process for uric acid detection,” IEEE Sensors Journal. Vol. 21, pp. 20229-20238, 2021.
[159] Liu N, Xiang X, Fu L, Cao Q, Huang R, Liu H, et al. “Regenerative field effect transistor biosensor for in vivo monitoring of dopamine in fish brains,” Biosensors and Bioelectronics. Vol. 188, pp. 113340, 2021.
[160] T-M. Pan and C-H. Lin, “High Performance NiOx Extended-Gate Field-Effect Transistor Biosensor for Detection of Uric Acid,” Journal of The Electrochemical Society. Vol. 168, pp. 017511, 2021.
[161] Jang H-J, Ahn J, Kim M-G, Shin Y-B, Jeun M, Cho W-J, et al. “Electrical signaling of enzyme-linked immunosorbent assays with an ion-sensitive field-effect transistor,” Biosensors and Bioelectronics. Vol. 64, pp. 318-323, 2015.
[162] O. Kutova, M. Dusheiko, NI. Klyui, and VA. Skryshevsky, “C-reactive protein detection based on ISFET structure with gate dielectric SiO2-CeO2,” Microelectronic Engineering. Vol. 215, pp. 110993, 2019.
[163] AE. Kuznetsov, NV. Komarova, EV. Kuznetsov, MS. Andrianova, VP. Grudtsov, EN. Rybachek, et al. “Integration of a field effect transistor-based aptasensor under a hydrophobic membrane for bioelectronic nose applications,” Biosensors and Bioelectronics. Vol. 129, pp. 29-35, 2019.
[164] R. Campos, J. Borme, and JR. Guerreiro, Jr G. Machado,MFt. Cerqueira, DY. Petrovykh, et al. “Attomolar label-free detection of DNA hybridization with electrolyte-gated graphene field-effect transistors,” ACS sensors. Vol. 4, pp. 286-293, 2019.
