Evaluation of wound healing activity of Echinophora platyloba extract on experimental full thickness skin wound in the rat

Subject Areas : Veterinary Clinical Pathology

ahmad  asghari ¹ (استادیار گروه علوم درمانگاهی دامپزشکی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران.)
maryam  Kardooni ² (دانشجوی دکترای حرفه‌ای دامپزشکی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران.)

Received: 2015-03-05 Accepted : 2015-05-20 Published : 2015-02-20

Keywords: Skin wound, Echinophora platyloba, Healing, Rats,

Abstract :

   There are some specific plants used in traditional medicine, one of which is Echinophora platyloba. This study was conducted to evaluate the effects of platyloba (Echinophora platyloba) on the experimental full-thickness wound healing in rats. In this study 80 adult male Wistar rats were used. They were randomly divided into four groups including control, placebo, therapeutic ointment 1.5% and 3%. Animals were anesthetized and scrubbed from the shoulder to the ilium. Then, a circular wound was made with a diameter of 15 mm on the back between scapula and ischial tuberosity. The control group received no medication, while the placebo group received eucerin, the third and fourth groups received 1.5 and 3% Echinophora platyloba ointment locally. Histological samples were taken on days 3, 7, 14 and 21 in each group, then all samples were sent to the laboratory and processed with H&E staining method. Histopathological evaluations showed better healing results in those groups which had received Echinophora platyloba extract in comparison to other groups. Moreover, wound healing was significantly better in these groups (p<0.05). In conclusion, the results obtained from this study indicate that Echinophora platyloba extract had positive effect on wound healing in rat.

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