Histogenesis study of the ovine lens

Subject Areas : Veterinary Clinical Pathology

M.A  Ebrahimi ¹ (Department of Basic Sciences, Faculty of Veterinary Medicine, Islamic Azad University- Tabriz Branch, Tabriz, Iran)
رضا  Najjar ² (Graduat of Veterinary Medicine, Islamic Azad University-Tabriz Branch, Tabriz, Iran)
رعنا  Keyhanmanesh ³ (Department of Physiology, Faculty of Veterinary Medicine, University of Medical Sciences, Tabriz, Iran)

Received: 2008-06-26 Accepted : 2010-01-04 Published : 2009-11-22

Keywords: Ovine, Histogenesis, Lens,

Abstract :

In this study, 78 sheep fetuses were used for the evaluation of anatomic and histologic aspects of lens with three methods (H&E, Verhoeff's and P.A.S. staining). The results showed that the lens vesicle was formed completely by 30th day and lost its contact with the superficial ectoderm. In 40th day of fetal period, the epithelium of the posterior wall of the lens gradually started to disappear due to its development and formation of forward facing elastic fibers limiting the internal space of the vesicle. By 150th day, the density and thickness of these fibers were increasing. In addition, at this day, the capsule of the posterior surface of the lens started to form. In 50th day of fetal period the internal space of vesicle was filled with elastic fibers and the epithelium of the anterior surface became simple cuboidal. At that day, the capsule of the anterior surface of the lens gradually was formed and in 60-day fetus, it became complete. By 150th day, its thickness was increased a little. After 80th day, the convexity of the posterior part would become more than the convexity of the anterior part because of the increased growth of lens fibers.

References:

1. پوستی، ا. (1385): بافت شناسی مقایسه­ای، انتشارات دانشگاه تهران، چاپ سوم، صفحات: 415-404.


2. سعادت نوری، م. و سیاه منصور، ح. (1382): اصول نگهداری و پرورش گوسفند، انتشارات اشرفی، صفحات: 30-20.


3. قاضی، س.ر.، رادمهر، ب. و رشیدی، ه. (1372): جنین شناسی حیوانات اهلی، انتشارات دانشگاه شیراز، صفحات: 188-184.


4. جان کوئیرا، ل.ک. (1382): بافت شناسی پایه، مترجم، بیله سوار، آ.، ملکی، ر.، یزدانی، ش.، مؤسسه فرهنگی انتشارات تیمورزاده، صفحات: 730- 704.
   
   
   1. Azuma, M.and Shearer, T.R. (1992): Induction of elongation in cultured rat lens epithelial cells by FGF and inhibition by selenite. Invest. Ophthalmol. Vis. Sci., 128: 456-464.
   
   
   2. Collinson, J.M., Hill, R.E. and West, J.D. (2000): Development of chicken lens cells in vitro. Cambridge, U.K., 127: 945-956.
   
   
   3. Churchill, A.J. and Booth, A. (1996): Growth and differentiation of sheep lens epithelial cells in vitro on matrix. Br. J. Ophthalmol., 80: 669-673.
   
   
   4. Dyce, K.M., Sae, W.O. and Wensing, C.Y.G. (1995): Text Book of Veterinary Anatomy. Saunders, London, pp: 333-336.
   
   
   5. Eleanor, A., Blakely, S., Kathleen, A., Bjornstad, P.Y., Chang, I. and Morgan, P. (2001): Growth and differentiation of human lens epithelial cells in vitro on matrix. Embryology Journal, 193(6): 85-93.
   
   
   6. Franco, A.J., Masot, A.J., Aguado, M.C., Gomez, L. and Redondo, E. (2004): Morphometric and immunohistochemical study of the eye development. Journal of Anatomy, 204(6): 501-512.
   
   
   7. Hogoz, K. and Whalter, H.J. (1998): Early organogenesis of the eye. Nippon Juigalku Zasshi, 65(2): 287-295.
   
   
   8. Getty, R. (1975): Sissen and Grossman's Anatomy of the Domestic Animals. Vol I, 5^th ed., pp: 1180-1200.
   
   
   9. Hitchcock, P.F., Macdonald, R.E., van de Ryt, J.T. and Wilson, S.W. (1996): Growth and Differentiation of goat Lens Cells In Vitro, Neurobiol., 29: 399-413.
   
   
   10. Hanson, I., Fletcher, J., Jordan, T., Brown, A., Taylor, D., Adams, R., et al. (1994): Effect of growth factor on eye lens development. Genet., 6: 168-173.
   
   
   11. Hamburg, A. (1967): The role of platelet growth factor in sheep lens cells differentiation. Am. J. Ophthalmol., 64: 729-733.
   
   
   12. McAvoy, J.W., Chamberlain, C.G., de Iongh, R.U., Richardson, N.A., Lovicu, F.J. (1991): The role of fibroblast growth factor in eye lens development. Ann NY Acad Sci., 638: 256-274.
   
   
   13. Mirzayans, F., Pearce, W.G., MacDonald, I.M. and Walter, M.A. (1995): Mutation in the RIEG1 gene in patients with Iridogonal syndrome Am. J. Hum. Genet. 57: 539-548.
   
   
   14. Nickel, R., Schumer, A. and Seiferle, E. (1986): Anatomy of Domestic Animals, Vol II. Verlag Paul Parey. Berlin. Hamburg. pp: 354-395.
   
   
   15. Piatigorsky, J. (1973): Insulin initiation of lens fiber differentiation in culture: elongation of embryonic lens epithelial cells. Dev Biol., 30: 214-216.
   
   
   16. Quinn, J.C., West, J.D. and Hill, R.E. (1996): Multiple functions for pax6 mouth eye and nasal development. Genes Dev., 10: 435-446.
   
   
   17. Richard, A. and Lang, D. (1996): Apoptosis in mammalian eye development: lens morphogenesis, vascular regression and immune privilege. Cell Death and Differentiation journal, 301(6): 121.
   
   
   18. Salder, T.W. (2004): Langmans Medical Embryology. 9^th ed. Mosby, London, pp: 321-325.
   
   
   19. Grindley, J.C., Davidson, D.R. and Hill, R.E. (1995): Development. Cambridge, U.K., 121: 1433-1442.
   
   
   20. Wormstone, I.M., Liu, CSC, Rakic, J.M., et al., (1992): Human lens epithelial cell proliferation in a protein-free medium. Invest Ophthalmol Vis Sci., pp: 301-316.
   
   
   21. Walther, C. and Gruss, P. (1991): Development. Cambridge, U.K., 113: 1435-1449.
   
   
   22. Wheater, P.R. and Burkitt, H.G. (1989): Functional Histology. 2^th ed., Churchill livingstone, pp: 318-330.