Determining drug resistance patterns of Clostridium perfringens isolates from acute necrotic enteritis (NE) outbreaks

Subject Areas : Veterinary Clinical Pathology

حسین Nikpiran ¹ , بهرام Shojadoost ² , S.M Peighambari ³

1 - Department of Clinical Sciences, Faculty of Veterinary Medicine, Islamic Azad University, Tabriz Branch, Tabriz, Iran
2 - Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
3 - Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

Received: 2008-04-20 Accepted : 2008-07-17 Published : 2008-02-20

Keywords: broiler chicken, Clostridium perfringens, drug resistance patterns, necrotic enteritis,

Abstract :

     In this study, after separating 40 Clostridium perfringens isolates from affected broiler flocks, the antibacterial susceptibility test revealed 39 drug resistance patterns in which 95% of the isolates were distributed into 38 different patterns (one isolate in each pattern) and only 5% of the isolates were placed in a single pattern (two isolates in a pattern). All 40 Clostridium perfringens isolates demonstrated resistance to chloramphenicol, vancomycin and sulfamethoxazole+trimethoprime, ranging from 0 to 17.5% while tetracycline, lincomycin and neomycin sulfate had a high level of resistance from 80 to 87.5%. Also an isolate demonstrated multiple resistance to more than 14 antibacterial compounds. 

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